NCT05943769 is a NA clinical trial of Apical microsurgery in Periapical Diseases, sponsored by Ain Shams University.

Who is sponsoring NCT05943769?

NCT05943769 is sponsored by Ain Shams University.

What drugs are being tested in NCT05943769?

Interventions in NCT05943769: Apical microsurgery.

What condition does NCT05943769 study?

NCT05943769 studies Periapical Diseases, Periapical Cyst.

Is NCT05943769 still recruiting?

NCT05943769 is currently completed. Last updated 13 July 2023.

Last reviewed 2023-07-13 · How we verify

NCT05943769

Name: Drug Landscape Pharmaceutical Database
Creator: Drug Landscape
Published: 2026-01-01
License: https://creativecommons.org/licenses/by/4.0/

The Impact of Root End Filling Material Type and the Application of Bone Graft on Healing of Periapical Tissues After Endodontic Microsurgery (A Clinical Randomized Controlled Trial)

Completed NA Last updated 13 July 2023

What this trial tests

NA trial testing Apical microsurgery in Periapical Diseases in 56 participants. Completed in 30 October 2022.

Timeline

1 January 2020

Primary endpoint
20 August 2021

30 October 2022

Quick facts

Lead sponsor	Ain Shams University
Phase	NA
Status	Completed
Study type	INTERVENTIONAL
Allocation	randomized
Design	parallel
Masking	triple
Primary purpose	treatment
Enrollment	56
Start date	1 January 2020
Primary completion	20 August 2021
Estimated completion	30 October 2022
Sites	1 location across Egypt

Drugs / interventions tested

Apical microsurgery

Conditions studied

Periapical Diseases — all drugs for Periapical Diseases →
Periapical Cyst — all drugs for Periapical Cyst →

Sponsor

Ain Shams University

Who can join

Adults 20 to 45, any sex, with Periapical Diseases or Periapical Cyst. Patients with the condition only — healthy volunteers not accepted.

Sponsor's own description

The goal of this triple blinded randomized clinical trial is to evaluate the effect of combining different bioactive root end filling materials with composite bone graft (xenogeneic mixed with autogenous bone fragments) on the healing process of periapical tissues after endodontic micro-surgery procedure on patients with small to moderate sized lesions. The main questions it aims to answer are: Will the use of Totalfill in Endodontic surgeries show comparable results to the gold standard MTA? Will the addition of composite bone graft (Xenogenic and Autogenous) affect the healing of small to moderate sized lesions? Is there any interaction between composite bone graft and different bioactive root-end filling materials? Participants were allocated to 4 different groups according to the root-end filling material used with or without bone graft. Reseachers compared between MTA only group, Totalfill only group, MTA with bone group, and Totalfill with bone group to evaluate healing of the periapical lesion using CBCT after 12 months follow up period.

Publications & conference data

1 peer-reviewed publication reference this trial (live from Europe PMC):

The impact of root end filling material type and the application of bone graft on healing of periapical tissues after endodontic microsurgery (a clinical randomized controlled trial).
Salah HM, Hashem AAR, Mustafa T, Soliman AH, et al · · 2024 · cited 4× · PMID 39455597 · DOI 10.1038/s41598-024-66033-w

Verify or expand the search:

Other recruiting trials for Periapical Diseases

Currently open trials in the same condition.

NCT07448571 — Evaluation of Revitalization Success Using i-PRF in Non-Surgical Root Canal Retreatment · NA · recruiting
NCT06643663 — Role of GTR on Healing Outcome & Quality of Life in Combined Endo Perio Lesions With Communication · NA · recruiting
NCT06252337 — Survival and Success of Two Different Filling Techniques · NA · active not recruiting
NCT05888935 — Detection of Periapical Lesions on Dental Panoramic Radiographs Based on Artificial Intelligence · recruiting

Other Ain Shams University trials

Trials by the same sponsor.

NCT07435493 — Fentanyl Versus Opioid Free Multimodal Analgesia for Perioperative Pain Control in Children With Mild to Moderate Obstru · NA · not yet recruiting
NCT07482540 — Role of Dexmedatomidine Drug in Prevention of Atrial Fibrillations Post Mitral Valve Surgery · NA · not yet recruiting
NCT07531030 — Posterior Pericapsular Deep Gluteal Block Combined With Pericapsular Nerve Group and Lateral Femoral Cutaneous Nerve Blo · NA · not yet recruiting
NCT06839027 — Arterial to Central co2gap in Relation to Outcome After Cardiopulmonary Bypass · not yet recruiting
NCT07516535 — DISS vs FANS in Suction-Assisted RIRS for Medium-Sized Renal Stones · NA · not yet recruiting

Verify against primary sources

ClinicalTrials.gov — authoritative US registry record
WHO ICTRP — international registry index
EU Clinical Trials Register
Sponsor press releases (Google)

Data sources for this page

Trial protocol + status: ClinicalTrials.gov NCT05943769 (US National Library of Medicine, public domain)
Publications: Europe PMC API search by NCT ID, retrieved 9 June 2026
Drug + disease cross-links: matched in real time against Drug Landscape's normalised drug + company + condition tables
Sponsor: as reported to ClinicalTrials.gov by Ain Shams University
Last refreshed: 13 July 2023

Drug Landscape aggregates and links these public records for informational use only. Always verify against the primary source before clinical or regulatory decisions. Canonical URL: https://druglandscape.com/trial/NCT05943769.

Primary sources · FDA · ClinicalTrials.gov · EMA · SEC EDGAR · ChEMBL · Wikidata · full sourcing