65 and older, any sex, with Depressive Symptoms or Aging. Patients with the condition only — healthy volunteers not accepted.
Results — posted to ClinicalTrials.gov
Per-arm endpoint measurements with 95% confidence intervals where reported. Source: trial results section.
Urinary Flavonoid BiomarkersPrimary· Baseline and Day 3 of intervention
Change in total flavonoid metabolites found in the urine. The values for the metabolites represent the relative abundance of each metabolite, rather than absolute quantification, with higher values reflecting higher levels of total flavonoid metabolites in the urine.
Group
Value
95% CI
Standard Dose Freeze-dried Blueberry Powder
398863
± 274183
Higher Dose Freeze-dried Blueberry Powder
1045795
± 661053
Inflammatory Biomarker C-reactive ProteinPrimary· Baseline and Day 3 of intervention
Change in serum C-reactive Protein
Group
Value
95% CI
Standard Dose Freeze-dried Blueberry Powder
-100
± 642
Higher Dose Freeze-dried Blueberry Powder
-635
± 1318
Inflammatory Biomarker Tumor Necrosis Factor AlphaSecondary· Baseline and Day 3 of intervention
Change in tumor necrosis factor alpha
Group
Value
95% CI
Standard Dose Freeze-dried Blueberry Powder
-0.03
± 0.11
Higher Dose Freeze-dried Blueberry Powder
0.06
± 0.08
Inflammatory Biomarker Interleukin 6Secondary· Baseline and Day 3 of intervention
Change in interleukin 6
Group
Value
95% CI
Standard Dose Freeze-dried Blueberry Powder
0.28
± 0.55
Higher Dose Freeze-dried Blueberry Powder
-1.3
± 3.0
Sponsor's own description
This randomized, cross-over, pilot study aims to compare preliminary impact of a standard dose of blueberry powder (24 g) vs a higher dose (48 g) on the bioavailability of flavonoids and inflammatory biomarkers in older adults with minor levels of depressive symptoms.
Publications & conference data
No peer-reviewed publications indexed yet for this trial. Completed trials usually publish results within 12-18 months.
NCT05817383 — Berries, Bugs, and the Blues
· NA
· completed
NCT05735587 — Blueberries, Inflammation, Motivation, and Physical Activity
· NA
· completed
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Drug + disease cross-links: matched in real time against Drug Landscape's normalised drug + company + condition tables
Sponsor: as reported to ClinicalTrials.gov by Hebrew SeniorLife
Last refreshed: 15 December 2025
Drug Landscape aggregates and links these public records for informational use only. Always verify against the primary source before clinical or regulatory decisions. Canonical URL: https://druglandscape.com/trial/NCT05937165.