NCT05936099

Adolescent Inpatient Tobacco and ENDS Intervention

Completed NA Results posted Last updated 9 February 2026

What this trial tests

NA trial testing E-cigarette & Tobacco Use Treatment Intervention in Vaping in 144 participants. Completed in 20 December 2025.

Timeline

1 August 2023

Primary endpoint
20 December 2024

20 December 2025

Quick facts

Lead sponsor	Children's Mercy Hospital Kansas City
Phase	NA
Status	Completed
Study type	INTERVENTIONAL
Allocation	randomized
Design	parallel
Masking	single
Primary purpose	treatment
Enrollment	144
Start date	1 August 2023
Primary completion	20 December 2024
Estimated completion	20 December 2025
Sites	1 location across United States

Drugs / interventions tested

• E-cigarette & Tobacco Use Treatment Intervention

Conditions studied

• Vaping — all drugs for Vaping →
• Smoking — all drugs for Smoking →

Sponsor

Children's Mercy Hospital Kansas City

Who can join

Adults 14 to 21, any sex, with Vaping or Smoking. Patients with the condition only — healthy volunteers not accepted.

Results — posted to ClinicalTrials.gov

Per-arm endpoint measurements with 95% confidence intervals where reported. Source: trial results section.

Self-reported 30-day Abstinence Primary · 3 month follow-up

Self reported cessation, assessed at 3 month follow up survey.

Group	Value	95% CI
Control	16
Intervention	25

Biochemically Verification of Past 30 Day Cessation Primary · 3 month follow-up

For participants who self-reported past 30 day cessation, an option was provided to biochemically verify cessation with a mailed saliva sample.

Group	Value	95% CI
Intervention	1
Control	2
Intervention	5
Control	2
Intervention	16
Control	10
Intervention	36
Control	24

Acceptability of Intervention - Satisfaction and Likeliness to Recommend Program Secondary · Study completion (approximately 12 weeks)

Ratings from participants on perceived acceptability (i.e., satisfaction and usefulness) of the intervention

Satisfaction with the intervention

Group	Value	95% CI
Intervention	0
Intervention	3
Intervention	8
Intervention	34

Likely to recommend the intervention to friends or family

Group	Value	95% CI
Intervention	1
Intervention	3
Intervention	20
Intervention	37

Acceptability of Intervention - Utility of Intervention Secondary · Study completion (approximately 12 weeks)

Acceptability of the intervention assessed by intervention element completion rates (i.e. overall uptake of support resources).

Made a quit plan during the index session

Group	Value	95% CI
Intervention	47

Were interested in nicotine replacement therapy during the index session

Group	Value	95% CI
Intervention	14

Were prescribed nicotine replacement therapy during the index session

Group	Value	95% CI
Intervention	11

Enrolled in a text-to-quit program during the index session

Group	Value	95% CI
Intervention	13

Were provided addiction resources information during the index session

Group	Value	95% CI
Intervention	67

Feasibility of Intervention - Duration of Intervention Secondary · Study completion (approximately 12 weeks)

Assessment of the feasibility of the intervention based on information about delivery gathered from the computerized decision making system (CDS) such as the duration of the intervention.

Group	Value	95% CI
Intervention	32	28 – 39

Feasibility of Intervention - Intervention Interruptions Secondary · Study completion (approximately 12 weeks)

Assessment of the feasibility of the intervention based on information about delivery gathered from the computerized decision making system (CDS) such as the number of interruptions (by clinical staff, parents, or others) that occurred during intervention delivery.

Group	Value	95% CI
Intervention	0	0 – 5

Feasibility of Intervention - Health Educator Survey Secondary · Study completion (approximately 12 weeks)

Feasibility of the intervention as assessed by the health educator who delivered the intervention.

Agreed/ Strongly Agreed the intervention was easy to deliver

Group	Value	95% CI
Intervention	95

Agreed/Strongly Agreed there was enough time to deliver the intervention

Group	Value	95% CI
Intervention	94

Fidelity of Intervention Delivered by a Health Educator Secondary · Study completion (approximately 12 weeks)

Extent of fidelity achieved in intervention delivery by a health educator. The mean score was calculated from 0 (never/very poor) to 5 (always/very good) for each of the 10 fidelity rating questions, which were summed, with a maximum possible score of 50. The scale utilized was an adapted version of the Motivational Interviewing Treatment Integrity tool (MITI).

Group	Value	95% CI
Intervention	43	± 3.1

Sponsor's own description

The purpose of this study is to develop and evaluate an evidence-based intervention to assist adolescents and young adults with current vaping to quit vaping and smoking.

Publications & conference data

2 peer-reviewed publications reference this trial (live from Europe PMC):

1. Treatment of e-cigarette use among hospitalised adolescents and young adults: a protocol for intervention development and evaluation of preliminary efficacy and implementation outcomes in a randomised controlled trial.
   Wooten S, Catley D, Miller MK, Wilson K, et al · · 2025 · PMID 39779271 · DOI 10.1136/bmjopen-2024-094323
2. Treatment of E-Cigarette Use Among Hospitalized Adolescents and Young Adults: A protocol for intervention development and evaluation of preliminary efficacy and implementation outcomes in a randomized controlled trial
   Wooten S, Catley D, Miller M, Wilson K, et al · · 2024 · DOI 10.21203/rs.3.rs-4474076/v1