Last reviewed · How we verify
NCT05932251: ToPMedDiP
Towards Precision Medicine for Diabetes in Pregnancy
trial testing Metformin in Gestational Diabetes in 103 participants. Suspended.
31 January 2025
Quick facts
| Lead sponsor | Zuyderland Medisch Centrum |
|---|---|
| Status | Suspended |
| Study type | OBSERVATIONAL |
| Enrollment | 103 |
| Start date | 19 June 2023 |
| Primary completion | 31 January 2025 |
| Estimated completion | 30 September 2025 |
| Sites | 1 location across Netherlands |
Drugs / interventions tested
- Metformin (metformin) — full drug profile →
Conditions studied
- Gestational Diabetes — all drugs for Gestational Diabetes →
- Gestational Diabetes Mellitus — all drugs for Gestational Diabetes Mellitus →
Sponsor
Zuyderland Medisch Centrum — full company profile →
Who can join
Adults 18 to 45, female only, with Gestational Diabetes or Gestational Diabetes Mellitus. Patients with the condition only — healthy volunteers not accepted.
Sponsor's own description
Rationale: Gestational diabetes is currently treated by the one-size-fits-all-approach. Treatment efficacy is poorly defined and inconsiderate of patients clinical presentation Objective: To characterize the efficacy of pharmacological treatment of gestational diabetes mellitus between patients with distinct metabolic phenotypes Study design: Prospective observational study, in metformin-treatment efficacy is compared between patients with GDM caused by insulin resistance and patients with GDM caused by low insulin secretion. Study population: A prospective cohort of 103 women with diagnosed gestational diabetes mellitus treated by metformin. Main study parameters/endpoints: Primary outcomes is the glucose-disposition-index in late pregnancy (35-37 weeks gestation) and requirement for supplemental insulin-treatment. Secondary outcomes include insulin sensitivity (Matsuda-index), insulin secretion (Stumvoll-index), HbA1c, gestational weight gain, body composition, physical activity, eating behavior, plasma biomarkers, glucose control, and maternal and infant pregnancy outcomes.
Publications & conference data
1 peer-reviewed publication reference this trial (live from Europe PMC):
-
Precision gestational diabetes treatment: a systematic review and meta-analyses.
Benham JL, Gingras V, McLennan NM, Most J, et al · · 2023 · cited 25× · PMID 37794196 · DOI 10.1038/s43856-023-00371-0
Verify or expand the search:
- PubMed search for NCT05932251
- Europe PMC full search
- ASCO Meeting Library
- ESMO Meeting Library
- bioRxiv preprints
- medRxiv preprints
- Google Scholar
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Other recruiting trials for Gestational Diabetes
Currently open trials in the same condition.
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Trials by the same sponsor.
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Verify against primary sources
- ClinicalTrials.gov — authoritative US registry record
- WHO ICTRP — international registry index
- EU Clinical Trials Register
- Sponsor press releases (Google)
- Trial protocol + status: ClinicalTrials.gov NCT05932251 (US National Library of Medicine, public domain)
- Publications: Europe PMC API search by NCT ID, retrieved 10 June 2026
- Drug + disease cross-links: matched in real time against Drug Landscape's normalised drug + company + condition tables
- Sponsor: as reported to ClinicalTrials.gov by Zuyderland Medisch Centrum
- Last refreshed: 19 August 2025
Drug Landscape aggregates and links these public records for informational use only. Always verify against the primary source before clinical or regulatory decisions. Canonical URL: https://druglandscape.com/trial/NCT05932251.
Primary sources · FDA · ClinicalTrials.gov · EMA · SEC EDGAR · ChEMBL · Wikidata · full sourcing