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High Protein, Core Muscle Rehab, Muscular Electrostimulation in Prolonged Mechanical Ventilation
NA trial testing UC + high protein diet (HP) in Prolonged Mechanical Ventilation in 100 participants. Completed in 21 March 2025.
| Lead sponsor | Chang Gung Memorial Hospital |
|---|---|
| Phase | NA |
| Status | Completed |
| Study type | INTERVENTIONAL |
| Allocation | randomized |
| Design | parallel |
| Masking | none |
| Primary purpose | other |
| Enrollment | 100 |
| Start date | 18 September 2023 |
| Primary completion | 21 March 2025 |
| Estimated completion | 21 March 2025 |
| Sites | 1 location across Taiwan |
Chang Gung Memorial Hospital
Adults 20 to 100, any sex, with Prolonged Mechanical Ventilation or Protein Deficiency. Patients with the condition only — healthy volunteers not accepted.
Per-arm endpoint measurements with 95% confidence intervals where reported. Source: trial results section.
weaning success defined as weaning from ventilator for 5 consecutive days
| Group | Value | 95% CI |
|---|---|---|
| Usual care | 3 | |
| UC + high protein diet (HP) | 20 | |
| UC + HP + core muscle rehabilitation | 22 | |
| UC + HP + core muscle rehabilitation + neuromuscular electric stimulation (NMES) | 26 |
through the end of admission, up to 3 months
| Group | Value | 95% CI |
|---|---|---|
| Usual care | 3 | |
| UC + high protein diet (HP) | 5 | |
| UC + HP + core muscle rehabilitation | 5 | |
| UC + HP + core muscle rehabilitation + neuromuscular electric stimulation (NMES) | 4 |
total ventilator use days in this admission
| Group | Value | 95% CI |
|---|---|---|
| Usual care | 74.4 | ± 27.1 |
| UC + high protein diet (HP) | 56.5 | ± 24.1 |
| UC + HP + core muscle rehabilitation | 57.1 | ± 29.9 |
| UC + HP + core muscle rehabilitation + neuromuscular electric stimulation (NMES) | 41.1 | ± 12.9 |
total ICU stay in this admission
| Group | Value | 95% CI |
|---|---|---|
| Usual care | 31.3 | ± 12.8 |
| UC + high protein diet (HP) | 25.7 | ± 7.9 |
| UC + HP + core muscle rehabilitation | 26.0 | ± 8.3 |
| UC + HP + core muscle rehabilitation + neuromuscular electric stimulation (NMES) | 23.7 | ± 7.5 |
The goal of this clinical trial is to learn about in patients with prolong mechanical ventilation. This main questions aims to answer are: * High protein formula intake benefit in successful weaning from ventilator * Core muscle rehabilitation benefit in successful weaning from ventilator * neuromuscular electric stimulation benefit in successful weaning from ventilator Participants will receive high protein diet, core muscle rehabilitation, neuromuscular electric stimulation (NMES). Researchers will compare patients with interventions to control group to see if high protein diet, core muscle rehabilitation, neuromuscular electric stimulation works.
No peer-reviewed publications indexed yet for this trial. Completed trials usually publish results within 12-18 months.
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Primary sources · FDA · ClinicalTrials.gov · EMA · SEC EDGAR · ChEMBL · Wikidata · full sourcing