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NCT05925036: MSCPainRelief
Novel Cellular Therapy for the Treatment of Pain Associated With Chronic Pancreatitis
Phase 1 trial testing Mesenchymal stem cells in Chronic Pancreatitis in 40 participants. Currently enrolling.
31 December 2026
Quick facts
| Lead sponsor | VA Office of Research and Development |
|---|---|
| Phase | Phase 1 |
| Status | Recruiting now |
| Study type | INTERVENTIONAL |
| Allocation | randomized |
| Design | parallel |
| Masking | quadruple |
| Primary purpose | treatment |
| Enrollment | 40 |
| Start date | 1 January 2024 |
| Primary completion | 31 December 2026 |
| Estimated completion | 31 December 2027 |
| Sites | 1 location across United States |
Drugs / interventions tested
- Mesenchymal stem cells — full drug profile →
- Placebo
Conditions studied
- Chronic Pancreatitis — all drugs for Chronic Pancreatitis →
- Chronic Pain — all drugs for Chronic Pain →
Sponsor
VA Office of Research and Development — full company profile →
Who can join
Adults 18 to 75, any sex, with Chronic Pancreatitis or Chronic Pain. Patients with the condition only — healthy volunteers not accepted.
Sponsor's own description
The goal of this clinical trial is to test whether adult stem cells, called mesenchymal stem cells (MSCs) collected from the patient's bone marrow can help reduce pain caused by chronic pancreatitis and improve pancreatic function.
Publications & conference data
4 peer-reviewed publications reference this trial (live from Europe PMC):
-
Stem cell-based therapy for fibrotic diseases: mechanisms and pathways.
Taherian M, Bayati P, Mojtabavi N. · · 2024 · cited 18× · PMID 38886859 · DOI 10.1186/s13287-024-03782-5 -
Emerging Landscape of Mesenchymal Stem Cell Senescence Mechanisms and Implications on Therapeutic Strategies.
Wang J, Zhang M, Wang H. · · 2024 · cited 13× · PMID 39144566 · DOI 10.1021/acsptsci.4c00284 -
Optimization strategies for mesenchymal stem cell-based analgesia therapy: a promising therapy for pain management.
Zhang J, Wu P, Wen Q. · · 2024 · cited 4× · PMID 39020426 · DOI 10.1186/s13287-024-03828-8 -
Navigating chronic pancreatitis pain: a pathophysiological and therapeutic overview.
Lin Z, Pandol S, Apte M, Jiang Y. · · 2025 · cited 2× · PMID 40708786 · DOI 10.3389/fphys.2025.1622845
Verify or expand the search:
- PubMed search for NCT05925036
- Europe PMC full search
- ASCO Meeting Library
- ESMO Meeting Library
- bioRxiv preprints
- medRxiv preprints
- Google Scholar
Related trials
Other trials of Mesenchymal stem cells
Trials testing the same drug.
- NCT06727721 — Safety and Efficacy of OCN19-overexpressed Human Umbilical Cord-derived Mesenchymal Stem Cells in the Treatment of Refra · Phase 2 · recruiting
- NCT06514378 — Safety of Endobronchial Mesenchymal Stromal Cells in the Treatment of Chronic Lung Allograft Dysfunction · Phase 1 · recruiting
- NCT05872659 — Mesenchymal Stem Cells for Immune Non-responder Patients With HIV Infection · EARLY_PHASE1 · unknown
- NCT07039318 — Mesenchymal Stem Cell Therapy in Diabetic Kidney Disease-A Double-blind, Placebo-controlled, Randomized Clinical Trial · Phase 2 · completed
- NCT04194671 — Clinical Trial of Mesenchymal Stem Cells in the Treatment of Severe Acute Kidney Injury · Phase 1, PHASE2 · unknown
Other recruiting trials for Chronic Pancreatitis
Currently open trials in the same condition.
- NCT07439757 — AI-Powered Precision Decision-Making for Pancreatic Diseases · recruiting
- NCT06655051 — Single Plastic Stent Vs. Fully Covered Self-Expanding Metal Stent on Benign Biliary Stricture Secondary to Chronic Pancr · NA · recruiting
- NCT06937294 — Metformin in Post Chronic Pancreatitis Diabetes Mellitus · Phase 4 · recruiting
- NCT07109180 — Robot-assisted Versus Open Lateral Pancreaticojejunostomy for the Treatment of Symptomatic Chronic Pancreatitis (PANACOT · NA · recruiting
- NCT06925204 — Natural Course and Therapeutic Effect of Chronic Pancreatitis · recruiting
Other VA Office of Research and Development trials
Trials by the same sponsor.
- NCT07456150 — Personalizing Veteran Pain Care: Adapting Coaching Interventions to Support Maintenance of Self-Care · Phase 1 · not yet recruiting
- NCT06746727 — The Development of a Transdiagnostic Intervention to Improve Social Functioning and Intimate Relationships Among Veteran · NA · not yet recruiting
- NCT07362576 — Perinatal Peer Support for Veterans With Serious Mental Illness · NA · not yet recruiting
- NCT06766331 — Integrated Care Versus Usual Care for Opioid Use Disorder and Infectious Diseases in Veterans · NA · not yet recruiting
- NCT07397195 — ACT for Veterans With IBD and Mental Health Challenges · NA · not yet recruiting
Verify against primary sources
- ClinicalTrials.gov — authoritative US registry record
- WHO ICTRP — international registry index
- EU Clinical Trials Register
- Sponsor press releases (Google)
- Trial protocol + status: ClinicalTrials.gov NCT05925036 (US National Library of Medicine, public domain)
- Publications: Europe PMC API search by NCT ID, retrieved 10 June 2026
- Drug + disease cross-links: matched in real time against Drug Landscape's normalised drug + company + condition tables
- Sponsor: as reported to ClinicalTrials.gov by VA Office of Research and Development
- Last refreshed: 7 April 2026
Drug Landscape aggregates and links these public records for informational use only. Always verify against the primary source before clinical or regulatory decisions. Canonical URL: https://druglandscape.com/trial/NCT05925036.
Primary sources · FDA · ClinicalTrials.gov · EMA · SEC EDGAR · ChEMBL · Wikidata · full sourcing