NCT05914896 is a NA clinical trial of HighOsmo in Acute Kidney Injury, sponsored by Umeå University.

Who is sponsoring NCT05914896?

NCT05914896 is sponsored by Umeå University.

What drugs are being tested in NCT05914896?

Interventions in NCT05914896: HighOsmo.

What condition does NCT05914896 study?

NCT05914896 studies Acute Kidney Injury, Osmolality Disturbance, Cardiopulmonary Bypass.

Is NCT05914896 still recruiting?

NCT05914896 is currently completed. Last updated 22 June 2023.

Last reviewed 2023-06-22 · How we verify

NCT05914896

Name: Drug Landscape Pharmaceutical Database
Creator: Drug Landscape
Published: 2026-01-01
License: https://creativecommons.org/licenses/by/4.0/

Hyperosmolality and Acute Kidney Injury After Cardiac Surgery

Completed NA Last updated 22 June 2023

What this trial tests

NA trial testing HighOsmo in Acute Kidney Injury in 200 participants. Completed in 24 June 2020.

Timeline

24 April 2019

Primary endpoint
24 June 2020

24 June 2020

Quick facts

Lead sponsor	Umeå University
Phase	NA
Status	Completed
Study type	INTERVENTIONAL
Allocation	randomized
Design	parallel
Masking	quadruple
Primary purpose	prevention
Enrollment	200
Start date	24 April 2019
Primary completion	24 June 2020
Estimated completion	24 June 2020
Sites	1 location across Sweden

Drugs / interventions tested

HighOsmo — full drug profile →

Conditions studied

Acute Kidney Injury — all drugs for Acute Kidney Injury →
Osmolality Disturbance — all drugs for Osmolality Disturbance →
Cardiopulmonary Bypass — all drugs for Cardiopulmonary Bypass →

Sponsor

Umeå University

Who can join

65 and older, any sex, with Acute Kidney Injury or Osmolality Disturbance. Patients with the condition only — healthy volunteers not accepted.

Sponsor's own description

The goal of this randomized controlled trial is to test if a hyperosmolar prime solution used for cardiopulmonary bypass increases the risk for acute postoperative kidney injury.

Publications & conference data

2 peer-reviewed publications reference this trial (live from Europe PMC):

Diuretics for preventing and treating acute kidney injury.
Hashimoto H, Yamada H, Murata M, Watanabe N. · · 2025 · cited 3× · PMID 39878152 · DOI 10.1002/14651858.cd014937.pub2
Plasma hyperosmolality during cardiopulmonary bypass is a risk factor for postoperative acute kidney injury: Results from double blind randomised controlled trial.
Svenmarker S, Claesson Lingehall H, Malmqvist G, Appelblad M. · · 2025 · cited 2× · PMID 38513672 · DOI 10.1177/02676591241240726

Verify or expand the search:

Other recruiting trials for Acute Kidney Injury

Currently open trials in the same condition.

NCT07273838 — Sodium-Glucose Cotransporter-2 Inhibitor for Patients With Acute Cardiorenal Syndrome · Phase 2 · recruiting
NCT07262320 — Epidemiology and Processes of Care for Renal Replacement Therapy in Acute Kidney Injury in Latin America · recruiting
NCT07351149 — Postoperative Acute Kidney Injury in Children Undergoing Major Non-cardiac Surgery · recruiting
NCT07215702 — A Study to Investigate the Efficacy, Safety, and Tolerability of AZD4144in Participants With Sepsis-associated Acute Kid · Phase 2 · recruiting
NCT06654193 — Allogeneic HB-adMSCs vs Placebo for the Treatment of Acute Kidney Injury · Phase 1, PHASE2 · recruiting

Other Umeå University trials

Trials by the same sponsor.

NCT07407946 — Blended Trauma-Focused Cognitive Behavioral Therapy With Compassion · NA · recruiting
NCT07346820 — VDJ-recombination of the B-cell Receptor Following Hematopoietic Stem Cell Transplantation · not yet recruiting
NCT07417358 — Single-Stapled Technique for Colorectal Anastomosis · recruiting
NCT07316426 — Preoptimisation in Ventral Hernia Surgery · NA · recruiting
NCT07170722 — Sub-threshold DRG Stimulation vs Sham in Established Responders · NA · completed

Verify against primary sources

ClinicalTrials.gov — authoritative US registry record
WHO ICTRP — international registry index
EU Clinical Trials Register
Sponsor press releases (Google)

Data sources for this page

Trial protocol + status: ClinicalTrials.gov NCT05914896 (US National Library of Medicine, public domain)
Publications: Europe PMC API search by NCT ID, retrieved 10 June 2026
Drug + disease cross-links: matched in real time against Drug Landscape's normalised drug + company + condition tables
Sponsor: as reported to ClinicalTrials.gov by Umeå University
Last refreshed: 22 June 2023

Drug Landscape aggregates and links these public records for informational use only. Always verify against the primary source before clinical or regulatory decisions. Canonical URL: https://druglandscape.com/trial/NCT05914896.

Primary sources · FDA · ClinicalTrials.gov · EMA · SEC EDGAR · ChEMBL · Wikidata · full sourcing