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NCT05912881
Chemosensory Dysfunction and Recovery in Endoscopic Endonasal Skull Base Surgery
NA trial testing Olfactory training in Anosmia in 41 participants. Completed in 1 January 2026.
1 January 2026
Quick facts
| Lead sponsor | Johns Hopkins University |
|---|---|
| Phase | NA |
| Status | Completed |
| Study type | INTERVENTIONAL |
| Allocation | randomized |
| Design | parallel |
| Masking | quadruple |
| Primary purpose | treatment |
| Enrollment | 41 |
| Start date | 1 February 2023 |
| Primary completion | 1 January 2026 |
| Estimated completion | 1 January 2026 |
| Sites | 1 location across United States |
Drugs / interventions tested
- Olfactory training
- Placebo training
Conditions studied
- Anosmia — all drugs for Anosmia →
- Skull Base Neoplasms — all drugs for Skull Base Neoplasms →
Sponsor
Johns Hopkins University
Who can join
18 and older, any sex, with Anosmia or Skull Base Neoplasms. Patients with the condition only — healthy volunteers not accepted.
Sponsor's own description
The investigators hypothesize that patients undergoing endoscopic endonasal skull base surgery experience clinically meaningful and modifiable disruptions in postoperative chemosensory function and quality of life, and the investigators further hypothesize that olfactory training in the postoperative period may significantly hasten normalization of patients' chemosensory perturbations. This tailored prospective study seeks to fulfill a significant gap in the understanding of the characteristics, implications, and treatment options for postoperative olfactory and gustatory impairment following endoscopic endonasal skull base surgery.
Publications & conference data
No peer-reviewed publications indexed yet for this trial. Completed trials usually publish results within 12-18 months.
Verify or expand the search:
- PubMed search for NCT05912881
- Europe PMC full search
- ASCO Meeting Library
- ESMO Meeting Library
- bioRxiv preprints
- medRxiv preprints
- Google Scholar
Related trials
Other trials of Olfactory training
Trials testing the same drug.
- NCT06607653 — The Efficacy of Olfactory Training Intervention on Olfactory and Other Non-motor Symptoms in PD · NA · not yet recruiting
- NCT06066307 — Olfactory Performance in Culinary Arts Students · Phase 4 · unknown
- NCT05421195 — Clinical Treatment Research of COVID-19-related Olfactory Dysfunction · NA · unknown
Other recruiting trials for Anosmia
Currently open trials in the same condition.
- NCT06733636 — Scents of Progress: Leveraging a Novel Device for Olfactory Training in Older Adults · NA · recruiting
- NCT05562050 — Characteristics of the Anosmic Olfactory Mucosa · active not recruiting
- NCT05040659 — Longitudinal At Home Smell Testing to Detect Infection by SARS-CoV-2 · active not recruiting
- NCT05364125 — Olfactory Training on Smell Dysfunction Patients in HK · NA · recruiting
- NCT06423495 — Efficacy of Photobiomodulation in the Rehabilitation of Olfactory Dysfunctions Induced by Long COVID-19 · NA · recruiting
Other Johns Hopkins University trials
Trials by the same sponsor.
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Verify against primary sources
- ClinicalTrials.gov — authoritative US registry record
- WHO ICTRP — international registry index
- EU Clinical Trials Register
- Sponsor press releases (Google)
- Trial protocol + status: ClinicalTrials.gov NCT05912881 (US National Library of Medicine, public domain)
- Drug + disease cross-links: matched in real time against Drug Landscape's normalised drug + company + condition tables
- Sponsor: as reported to ClinicalTrials.gov by Johns Hopkins University
- Last refreshed: 18 February 2026
Drug Landscape aggregates and links these public records for informational use only. Always verify against the primary source before clinical or regulatory decisions. Canonical URL: https://druglandscape.com/trial/NCT05912881.
Primary sources · FDA · ClinicalTrials.gov · EMA · SEC EDGAR · ChEMBL · Wikidata · full sourcing