Last reviewed · How we verify
NCT05909319
Identification and Verification of Neutrophil Extracellular Trap Net Related Markers in Acute-on-chronic Liver Failure
trial in Acute-On-Chronic Liver Failure in 200 participants. Status unknown.
25 December 2024
Quick facts
| Lead sponsor | First Affiliated Hospital of Wenzhou Medical University |
|---|---|
| Status | Status unknown |
| Study type | OBSERVATIONAL |
| Enrollment | 200 |
| Start date | 25 June 2023 |
| Primary completion | 25 December 2024 |
| Estimated completion | 25 June 2025 |
Conditions studied
- Acute-On-Chronic Liver Failure — all drugs for Acute-On-Chronic Liver Failure →
Sponsor
First Affiliated Hospital of Wenzhou Medical University
Who can join
Adults 18 to 75, any sex, with Acute-On-Chronic Liver Failure. Patients with the condition only — healthy volunteers not accepted.
Sponsor's own description
Acute-on-chronic liver failure (ACLF) refers to the acute deterioration of liver function in patients with chronic liver disease. Neutrophils are a major component of the innate immune system, and previous studies have revealed enhanced production of neutrophil extracellular traps (NETs) in ACLF. However, there is still a lack of systematic research on the correlation between NETs and the prognosis of ACLF. We screened NETs related biomarkers through bioinformatics analysis, which play an important role in the diagnosis of ACLF. This study will explore whether these NETs related biomarkers also play an important role in the prognosis of ACLF and further investigate their role in the pathogenesis of ACLF.
Publications & conference data
1 peer-reviewed publication reference this trial (live from Europe PMC):
-
Neutrophil extracellular traps: A central player in liver diseases.
Wang H, Tsung A, Zhang H. · · 2026 · PMID 42190269 · DOI 10.1097/hc9.0000000000000970
Verify or expand the search:
- PubMed search for NCT05909319
- Europe PMC full search
- ASCO Meeting Library
- ESMO Meeting Library
- bioRxiv preprints
- medRxiv preprints
- Google Scholar
Related trials
Other recruiting trials for Acute-On-Chronic Liver Failure
Currently open trials in the same condition.
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- NCT06562803 — Efficacy and Safety of Cytokine Adsorption and Plasma Exchange in Patients With ACLF and Sepsis · NA · recruiting
- NCT06079021 — COOLEY- Study: aCute On chrOnic Liver failurE Using the cYtosorb Device · NA · recruiting
Other First Affiliated Hospital of Wenzhou Medical University trials
Trials by the same sponsor.
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Verify against primary sources
- ClinicalTrials.gov — authoritative US registry record
- WHO ICTRP — international registry index
- EU Clinical Trials Register
- Sponsor press releases (Google)
- Trial protocol + status: ClinicalTrials.gov NCT05909319 (US National Library of Medicine, public domain)
- Publications: Europe PMC API search by NCT ID, retrieved 10 June 2026
- Drug + disease cross-links: matched in real time against Drug Landscape's normalised drug + company + condition tables
- Sponsor: as reported to ClinicalTrials.gov by First Affiliated Hospital of Wenzhou Medical University
- Last refreshed: 18 June 2023
Drug Landscape aggregates and links these public records for informational use only. Always verify against the primary source before clinical or regulatory decisions. Canonical URL: https://druglandscape.com/trial/NCT05909319.
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