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NCT06079021: COOLEY
COOLEY- Study: aCute On chrOnic Liver failurE Using the cYtosorb Device
NA trial testing CytoSorb in Acute-On-Chronic Liver Failure in 20 participants. Currently enrolling.
30 September 2026
Quick facts
| Lead sponsor | University Hospital, Antwerp |
|---|---|
| Phase | NA |
| Status | Recruiting now |
| Study type | INTERVENTIONAL |
| Allocation | non randomized |
| Design | parallel |
| Masking | none |
| Primary purpose | treatment |
| Enrollment | 20 |
| Start date | 8 June 2024 |
| Primary completion | 30 September 2026 |
| Estimated completion | 30 September 2027 |
| Sites | 1 location across Belgium |
Drugs / interventions tested
- CytoSorb
Conditions studied
- Acute-On-Chronic Liver Failure — all drugs for Acute-On-Chronic Liver Failure →
- Anticoagulant Adverse Reaction — all drugs for Anticoagulant Adverse Reaction →
- Sarcopenia — all drugs for Sarcopenia →
- Ultrasonography — all drugs for Ultrasonography →
Sponsor
University Hospital, Antwerp
Who can join
18 and older, any sex, with Acute-On-Chronic Liver Failure or Anticoagulant Adverse Reaction. Patients with the condition only — healthy volunteers not accepted.
Sponsor's own description
A Prospective, Single-Center trial, in Patients With Acute on Chronic Liver Failure. Study of Standard Medical Care Plus CytoSorb® Compared to Standard Medical Care Alone in a historical group.
Publications & conference data
1 peer-reviewed publication reference this trial (live from Europe PMC):
-
The use of CytoSorb hemoadsorption in critically ill patients: a narrative review.
Lei K, Chen A, An X, Guo J, et al · · 2025 · cited 1× · PMID 41058625 · DOI 10.3389/fmed.2025.1628241
Verify or expand the search:
- PubMed search for NCT06079021
- Europe PMC full search
- ASCO Meeting Library
- ESMO Meeting Library
- bioRxiv preprints
- medRxiv preprints
- Google Scholar
Related trials
Other trials of CytoSorb
Trials testing the same drug.
- NCT05242289 — Cytokine Adsorption in Lung Transplantation · NA · completed
- NCT05259514 — CytoSorb SAH Trial · NA · terminated
- NCT05077124 — Safe and Timely Antithrombotic Removal (STAR) Registry · recruiting
- NCT05027529 — ECMOsorb Trial - Impact of a VA-ECMO in Combination With CytoSorb in Critically Ill Patients With Cardiogenic Shock · NA · completed
- NCT04157647 — Hemadsorption During and After Cardiopulmonary Bypass to Modulate the Inflammatory Response · NA · unknown
Other recruiting trials for Acute-On-Chronic Liver Failure
Currently open trials in the same condition.
- NCT07198854 — Risk Factors Affecting MSC Efficacy in ACLF Patients · recruiting
- NCT06996392 — Phase I Trial of QH-1A Hybrid Bio-Artificial Liver With Ex Vivo Blood-Purifying MSCs in Acute-on-Chronic Liver Failure · Phase 1 · active not recruiting
- NCT06831565 — Comparison of Blood Products Required Using Two Different ROTEM Cut-offs Before Invasive Procedures in Cirrhosis and Acu · NA · recruiting
- NCT06562803 — Efficacy and Safety of Cytokine Adsorption and Plasma Exchange in Patients With ACLF and Sepsis · NA · recruiting
- NCT05727722 — Micro-encapsulated Hepatocyte Intraperitoneal Transplantation in Liver Failure Adults · Phase 1 · recruiting
Other University Hospital, Antwerp trials
Trials by the same sponsor.
- NCT07455422 — A Study of Barrett's Esophagus Patients: Optimization of a Risk Model to Better Predict the Development of Cancer Recurr · NA · not yet recruiting
- NCT07020715 — A Phase IIa Study of Vitamin D3 Tolerogenic Dendritic Cells (tolDC) for Multiple Sclerosis · Phase 2 · not yet recruiting
- NCT07443761 — Patients Undergoing Pancreatic Surgery at the Antwerp University Hospital. · active not recruiting
- NCT06372847 — DISE-HNS Effect Study · NA · recruiting
- NCT07189091 — CReep and Maintenance flUid Sodium Chloride ADministration rEduction in cRitically Ill adultS · Phase 4 · recruiting
Verify against primary sources
- ClinicalTrials.gov — authoritative US registry record
- WHO ICTRP — international registry index
- EU Clinical Trials Register
- Sponsor press releases (Google)
- Trial protocol + status: ClinicalTrials.gov NCT06079021 (US National Library of Medicine, public domain)
- Publications: Europe PMC API search by NCT ID, retrieved 10 June 2026
- Drug + disease cross-links: matched in real time against Drug Landscape's normalised drug + company + condition tables
- Sponsor: as reported to ClinicalTrials.gov by University Hospital, Antwerp
- Last refreshed: 10 December 2024
Drug Landscape aggregates and links these public records for informational use only. Always verify against the primary source before clinical or regulatory decisions. Canonical URL: https://druglandscape.com/trial/NCT06079021.
Primary sources · FDA · ClinicalTrials.gov · EMA · SEC EDGAR · ChEMBL · Wikidata · full sourcing