NCT05907655 is a clinical trial of Nitroglycerin 0.3 MG in Migraine, sponsored by IRCCS San Raffaele.

Who is sponsoring NCT05907655?

NCT05907655 is sponsored by IRCCS San Raffaele.

What drugs are being tested in NCT05907655?

Interventions in NCT05907655: Nitroglycerin 0.3 MG, MRI, Blood sampling, Sleep profiler.

Is NCT05907655 still recruiting?

NCT05907655 is currently recruiting now. Last updated 22 June 2023.

Last reviewed 2023-06-22 · How we verify

NCT05907655

Name: Drug Landscape Pharmaceutical Database
Creator: Drug Landscape
Published: 2026-01-01
License: https://creativecommons.org/licenses/by/4.0/

Study of the Glymphatic System in Migraine

Recruiting now Last updated 22 June 2023

What this trial tests

trial testing Nitroglycerin 0.3 MG in Migraine in 50 participants. Currently enrolling.

Timeline

30 April 2023

Primary endpoint
30 June 2025

30 April 2026

Quick facts

Lead sponsor	IRCCS San Raffaele
Status	Recruiting now
Study type	OBSERVATIONAL
Enrollment	50
Start date	30 April 2023
Primary completion	30 June 2025
Estimated completion	30 April 2026
Sites	1 location across Italy

Drugs / interventions tested

Nitroglycerin 0.3 MG — full drug profile →
MRI — full drug profile →
Blood sampling — full drug profile →
Sleep profiler

Conditions studied

Migraine — all drugs for Migraine →

Sponsor

IRCCS San Raffaele — full company profile →

Who can join

Adults 18 to 60, any sex, with Migraine. Patients with the condition only — healthy volunteers not accepted.

Sponsor's own description

This study aimed to investigate the role of the glymphatic system in the initiation of migraine attacks, using non-invasive magnetic resonance imaging techniques and a validated model of migraine induction by nitroglycerin administration. Secondarily, the relationship between the function of the glymphatic system during nitroglycerin-induced migraine attacks and sleep architecture and plasma levels of migraine-involved neuropeptides will be investigated.

Publications & conference data

1 peer-reviewed publication reference this trial (live from Europe PMC):

Diffusion Tensor Imaging-Based Glymphatic Dysfunction Assessments in Migraine Syndromes: Mechanisms and Diagnostic Implications.
Lai E, Estin J, Zhou J, Sheffmaker R, et al · · 2025 · PMID 41462992 · DOI 10.3390/biomedicines13122981

Verify or expand the search:

Other recruiting trials for Migraine

Currently open trials in the same condition.

NCT07419607 — MIGRAFIT: Evaluating a Group Therapy Program Combining Physical Activity, Progressive Muscle Relaxation and Psychoeducat · NA · recruiting
NCT07487701 — Migraine Prevention With the Remote Electrical Neuromodulation (REN) Wearable: A Real-world Evidence Study · NA · active not recruiting
NCT07343427 — Impact of GON PRF on Central Sensitization in Migraine Patients · NA · active not recruiting
NCT07336056 — Nerivio Efficacy Under High-Frequency Use · Phase 4 · active not recruiting
NCT07385755 — Desvenlafaxine for Preventive Treatment of Frequent Migraines · NA · active not recruiting

Other IRCCS San Raffaele trials

Trials by the same sponsor.

NCT07454759 — Acute Sarcopenia in Hospitalized Older Adults · not yet recruiting
NCT07456462 — Making Antibody Treatments More Effective in Early Alzheimer's Disease Using 3Tesla Magnetica Resonance · NA · not yet recruiting
NCT07066878 — This Protocol Focuses on the Factors That Influence Survival, the Development of Complications and the Quality of Life B · not yet recruiting
NCT07526298 — Anticipating Irreversible Disability in Neuromyelitis Optica Spectrum Disorder: a Study to Assess Disease Activity in Ap · not yet recruiting
NCT07426471 — Delafloxacin Plasma and Tissue Concentration in Patients With Skin, Soft Tissue, and Bone and Joint Infections. · not yet recruiting

Verify against primary sources

ClinicalTrials.gov — authoritative US registry record
WHO ICTRP — international registry index
EU Clinical Trials Register
Sponsor press releases (Google)

Data sources for this page

Trial protocol + status: ClinicalTrials.gov NCT05907655 (US National Library of Medicine, public domain)
Publications: Europe PMC API search by NCT ID, retrieved 10 June 2026
Drug + disease cross-links: matched in real time against Drug Landscape's normalised drug + company + condition tables
Sponsor: as reported to ClinicalTrials.gov by IRCCS San Raffaele
Last refreshed: 22 June 2023

Drug Landscape aggregates and links these public records for informational use only. Always verify against the primary source before clinical or regulatory decisions. Canonical URL: https://druglandscape.com/trial/NCT05907655.

Primary sources · FDA · ClinicalTrials.gov · EMA · SEC EDGAR · ChEMBL · Wikidata · full sourcing