Who is sponsoring NCT05902312?

NCT05902312 is sponsored by Centre hospitalier de l'Université de Montréal (CHUM).

What drugs are being tested in NCT05902312?

Interventions in NCT05902312: transcranial magnetic stimulation.

What condition does NCT05902312 study?

NCT05902312 studies Major Depressive Disorder.

Is NCT05902312 still recruiting?

NCT05902312 is currently active, enrolled. Last updated 17 July 2025.

Last reviewed 2025-07-17 · How we verify

NCT05902312: ReDeeMD

Name: Drug Landscape Pharmaceutical Database
Creator: Drug Landscape
Published: 2026-01-01
License: https://creativecommons.org/licenses/by/4.0/

Repetitive Versus Deep Transcranial Magnetic Stimulation for Major Depression

Active, enrolled NA Last updated 17 July 2025

What this trial tests

NA trial testing transcranial magnetic stimulation in Major Depressive Disorder in 50 participants. Participants enrolled and being followed up; not accepting new ones.

Timeline

1 January 2024

Primary endpoint
1 January 2026

1 January 2026

Quick facts

Lead sponsor	Centre hospitalier de l'Université de Montréal (CHUM)
Phase	NA
Status	Active, enrolled
Study type	INTERVENTIONAL
Allocation	randomized
Design	parallel
Masking	single
Primary purpose	treatment
Enrollment	50
Start date	1 January 2024
Primary completion	1 January 2026
Estimated completion	1 January 2026
Sites	1 location across Canada

Drugs / interventions tested

transcranial magnetic stimulation — full drug profile →

Conditions studied

Major Depressive Disorder — all drugs for Major Depressive Disorder →

Sponsor

Centre hospitalier de l'Université de Montréal (CHUM)

Who can join

Adults 21 to 70, any sex, with Major Depressive Disorder. Patients with the condition only — healthy volunteers not accepted.

Sponsor's own description

The goal of this randomized controlled trial is to he effectiveness of two different TMS techniques in TRD, repetitive TMS (rTMS) and deep TMS (dTMS). The main questions it aims to answer are: type of study: clinical trial participant population/health conditions : Major Depressive Disorder To assess the superiority of dTMS over rTMS in TRD To evaluate the predictive capacity of scalable candidate biomarkers Participants will be randomly allocated to one of the two intervention groups (rTMS or dTMS).

Publications & conference data

2 peer-reviewed publications reference this trial (live from Europe PMC):

Comparison of therapeutic efficacy in depression between repetitive TMS and deep TMS.
Paganin W, Contini LM. · · 2025 · cited 2× · PMID 40423727 · DOI 10.1007/s00702-025-02944-w
Comparison of rTMS and dTMS in TRD: evidence gaps, cost-effectiveness, and ethical priorities.
Paganin W. · · 2025 · PMID 41573043 · DOI 10.3389/fpsyt.2025.1722486

Verify or expand the search:

Other trials of transcranial magnetic stimulation

Trials testing the same drug.

NCT07180654 — Menstrual Cycle TMS Plasticity Pilot · recruiting
NCT07138677 — Safty and Efficacy of MCI Network Guided TMS for Early Alzheimer's Disease: A Randomized, Double-blind Trial · NA · recruiting
NCT06837207 — Precision Transcranial Magnetic Stimulation for Depression Based on Orbital Frontal Cortex-habenula Circuitry · NA · not yet recruiting
NCT06919172 — iTBS/fMRI Study of Apex Control · NA · recruiting
NCT06383247 — The Efficacy and Safety of Precision REpetitive Transcranial Magnetic Stimulation in Alleviating Motor Symptom in Parkin · NA · recruiting

Other recruiting trials for Major Depressive Disorder

Currently open trials in the same condition.

NCT07219394 — Peer-Delivered Behavioral Activation in a CCBHC · NA · recruiting
NCT06705478 — Pramipexole Versus Escitalopram to Treat Major Depressive Disorder (MDD) and Comorbid MDD With Mild Neurocognitive Disor · Phase 2 · recruiting
NCT06749392 — An Individual-specific Synchrony Signature · NA · recruiting
NCT07316803 — Group Intervention for Romantic Relationships in Young Adults With Severe Mental Illness · NA · recruiting
NCT07242105 — Optimizing Brain Excitability in Depression · NA · recruiting

Other Centre hospitalier de l'Université de Montréal (CHUM) trials

Trials by the same sponsor.

NCT06735638 — Outside the Cage (OTC) Robotic Esophagectomy · Phase 1 · not yet recruiting
NCT07533253 — Rescue Distal Thrombectomy in Treatment for Persistent Distal Occlusions · NA · not yet recruiting
NCT05225272 — Effectiveness of an Enhanced Recovery After Surgery Protocol in Patients Undergoing On-pump Cardiac Surgery · not yet recruiting
NCT07497061 — Comparison of Two Surgical Techniques for the Treatment of Trigger Fingers: Longitudinal Opening Versus Complete A1 Pull · NA · not yet recruiting
NCT07196410 — KAN-004 for Immune-Related Diarrhea or Colitis · Phase 1 · recruiting

Verify against primary sources

ClinicalTrials.gov — authoritative US registry record
WHO ICTRP — international registry index
EU Clinical Trials Register
Sponsor press releases (Google)

Data sources for this page

Trial protocol + status: ClinicalTrials.gov NCT05902312 (US National Library of Medicine, public domain)
Publications: Europe PMC API search by NCT ID, retrieved 10 June 2026
Drug + disease cross-links: matched in real time against Drug Landscape's normalised drug + company + condition tables
Sponsor: as reported to ClinicalTrials.gov by Centre hospitalier de l'Université de Montréal (CHUM)
Last refreshed: 17 July 2025

Drug Landscape aggregates and links these public records for informational use only. Always verify against the primary source before clinical or regulatory decisions. Canonical URL: https://druglandscape.com/trial/NCT05902312.

Primary sources · FDA · ClinicalTrials.gov · EMA · SEC EDGAR · ChEMBL · Wikidata · full sourcing