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NCT05898074
Role of Novel RADA16 Hydrogel in Endoscopic Skull Base Surgery
NA trial testing Non-Absorbable Packing (Silastic Splint) in Skull Base Neoplasms in 30 participants. Currently enrolling.
9 June 2026
Quick facts
| Lead sponsor | Indiana University |
|---|---|
| Phase | NA |
| Status | Recruiting now |
| Study type | INTERVENTIONAL |
| Allocation | randomized |
| Design | parallel |
| Masking | single |
| Primary purpose | treatment |
| Enrollment | 30 |
| Start date | 9 October 2023 |
| Primary completion | 9 June 2026 |
| Estimated completion | 9 June 2026 |
| Sites | 1 location across United States |
Drugs / interventions tested
- Non-Absorbable Packing (Silastic Splint)
- PuraGel (RADA16) Hydrogel
Conditions studied
- Skull Base Neoplasms — all drugs for Skull Base Neoplasms →
- Cerebrospinal Fluid Leakage — all drugs for Cerebrospinal Fluid Leakage →
- Nasal; Hypertrophy, Mucous Membrane (Septum) — all drugs for Nasal; Hypertrophy, Mucous Membrane (Septum) →
Sponsor
Indiana University
Who can join
18 and older, any sex, with Skull Base Neoplasms or Cerebrospinal Fluid Leakage. Patients with the condition only — healthy volunteers not accepted.
Sponsor's own description
The purpose of this study is to specifically evaluate the effectiveness of PuraGel, a RADA16 polypeptide hydrogel, in expediting post-operative healing and re-mucosalization of the nasoseptal flap harvest site during endoscopic skull base surgery and the impact on patient and sinonasal morbidity.
Publications & conference data
1 peer-reviewed publication reference this trial (live from Europe PMC):
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A smart nanocomposite bioactive ink for controlled siRNA delivery in calvarial mesenchymal stromal cells as a minimally invasive treatment for craniosynostosis.
Salvati M, Tiberio F, Giacon N, Augello A, et al · · 2026 · PMID 41647289 · DOI 10.1093/rb/rbaf115
Verify or expand the search:
- PubMed search for NCT05898074
- Europe PMC full search
- ASCO Meeting Library
- ESMO Meeting Library
- bioRxiv preprints
- medRxiv preprints
- Google Scholar
Related trials
Other recruiting trials for Skull Base Neoplasms
Currently open trials in the same condition.
- NCT05607888 — Prospective Study of Sinonasal and Skull-base Tumours Management · recruiting
Other Indiana University trials
Trials by the same sponsor.
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Verify against primary sources
- ClinicalTrials.gov — authoritative US registry record
- WHO ICTRP — international registry index
- EU Clinical Trials Register
- Sponsor press releases (Google)
- Trial protocol + status: ClinicalTrials.gov NCT05898074 (US National Library of Medicine, public domain)
- Publications: Europe PMC API search by NCT ID, retrieved 10 June 2026
- Drug + disease cross-links: matched in real time against Drug Landscape's normalised drug + company + condition tables
- Sponsor: as reported to ClinicalTrials.gov by Indiana University
- Last refreshed: 9 April 2026
Drug Landscape aggregates and links these public records for informational use only. Always verify against the primary source before clinical or regulatory decisions. Canonical URL: https://druglandscape.com/trial/NCT05898074.
Primary sources · FDA · ClinicalTrials.gov · EMA · SEC EDGAR · ChEMBL · Wikidata · full sourcing