Last reviewed · How we verify
NCT05892562
A Causal Relationship Study Between Anxiety, Depression, and Rheumatoid Arthritis
trial testing No intervention in Rheumatoid Arthritis in 500 participants. Status unknown.
15 July 2023
Quick facts
| Lead sponsor | Shate Xiang |
|---|---|
| Status | Status unknown |
| Study type | OBSERVATIONAL |
| Enrollment | 500 |
| Start date | 15 December 2022 |
| Primary completion | 15 July 2023 |
| Estimated completion | 15 July 2023 |
| Sites | 1 location across China |
Drugs / interventions tested
- No intervention
Conditions studied
- Rheumatoid Arthritis — all drugs for Rheumatoid Arthritis →
- Anxiety — all drugs for Anxiety →
- Depression — all drugs for Depression →
Sponsor
Shate Xiang
Who can join
Eligibility, any sex, with Rheumatoid Arthritis or Anxiety. Patients with the condition only — healthy volunteers not accepted.
Sponsor's own description
Rheumatoid arthritis (RA) is a systemic chronic inflammatory disease, and depression and anxiety are among the most common comorbidities in RA patients, with a high prevalence rate. Epidemiological studies have found that joint deformities, severe pain, positive serum RF titers, as well as comorbidities such as hypertension, insomnia, pain, and fatigue are significantly associated with depression and anxiety in RA patients. Currently, clinical studies have found that the relief of depression or anxiety is one of the expected treatment goals for RA patients. Due to the unclear pathogenic factors of depression or anxiety in RA patients, there is a lack of effective clinical treatment options. Therefore, this study will use a "causal inference model" to identify possible "mediating variables" that may lead to the comorbidity of RA and emotional disorders through clinical investigation, aiming to improve the precision of treatment for physicians.
Publications & conference data
1 peer-reviewed publication reference this trial (live from Europe PMC):
-
Mediators of the association between rheumatoid arthritis and depression.
Xiang S, Xu D, Yang K, Hu C, et al · · 2025 · PMID 41331562 · DOI 10.1186/s12889-025-25231-5
Verify or expand the search:
- PubMed search for NCT05892562
- Europe PMC full search
- ASCO Meeting Library
- ESMO Meeting Library
- bioRxiv preprints
- medRxiv preprints
- Google Scholar
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Verify against primary sources
- ClinicalTrials.gov — authoritative US registry record
- WHO ICTRP — international registry index
- EU Clinical Trials Register
- Sponsor press releases (Google)
- Trial protocol + status: ClinicalTrials.gov NCT05892562 (US National Library of Medicine, public domain)
- Publications: Europe PMC API search by NCT ID, retrieved 9 June 2026
- Drug + disease cross-links: matched in real time against Drug Landscape's normalised drug + company + condition tables
- Sponsor: as reported to ClinicalTrials.gov by Shate Xiang
- Last refreshed: 7 June 2023
Drug Landscape aggregates and links these public records for informational use only. Always verify against the primary source before clinical or regulatory decisions. Canonical URL: https://druglandscape.com/trial/NCT05892562.
Primary sources · FDA · ClinicalTrials.gov · EMA · SEC EDGAR · ChEMBL · Wikidata · full sourcing