12 and older, any sex, with Behavior, Health. Patients with the condition only — healthy volunteers not accepted.
Results — posted to ClinicalTrials.gov
Per-arm endpoint measurements with 95% confidence intervals where reported. Source: trial results section.
Number of Participants With Change in Delay Discounting 5 Trial Adjusted MeasurePrimary· Baseline, 7 weeks
This measure asks participants to select between a smaller monetary amount available now and a larger monetary amount available at a delay (i.e., 1 day, 1 week, 1 month, 6 months, 1 year, 5 years, and 25 years). K-values, reflecting the indifference points at which participants preference between smaller and larger rewards, are computed. Because k-values are typically skewed, they are log-transformed before analysis. Scores are not bounded with a minimum and maximum value, but higher scores indicate a preference for smaller-sooner rewards relative to larger rewards available after a delay. Num
Group
Value
95% CI
Computer-based Working Memory Training Program
3
Change in Consideration of Future Consequences ScalePrimary· Baseline, 7 weeks
The Consideration of Future Consequences Scale1 (CFCS-14) is a 14-item self-report questionnaire that assesses active consideration of longer-term implications of an individual's actions. Lower scores on the CFCS-14 are associated with a greater focus on immediate needs and have been found to be associated with less engagement in health behaviors and greater substance use. Individual items are rated on a scale from 1 to 7; items are summed to create a total scores ranging from 14-98. Change in CFCS-14 score is measured by comparing baseline scores with scores at the post-intervention assessmen
Baseline assessment
Group
Value
95% CI
Computer-based Working Memory Training Program
58.4
± 7.3
Post-training assessment
Group
Value
95% CI
Computer-based Working Memory Training Program
58.7
± 10.9
Change in Tower of HanoiPrimary· Baseline, 7 weeks
Tower of Hanoi (TOH) is a measure of planning ahead. It requires the participant to move disks of varying sizes between three pegs in order to create a specified design. Participants are instructed to follow specific rules for play and are awarded points for making each design in the least number of moves. The minimum overall score a participant can get is zero and the maximum score is 72, with higher scores indicating better performance. The current study will use the TOH measure from the Delis-Kaplan Executive Function System (D-KEFS; Delis, Kaplan \& Kramer, 2001). The test is normed on cli
Baseline Assessment
Group
Value
95% CI
Computer-based Working Memory Training Program
51.36
± 4.9
Post-training Assessment
Group
Value
95% CI
Computer-based Working Memory Training Program
50.9
± 16.4
Change in Letter Number SequencingPrimary· Baseline, 7 weeks
Letter Number Sequencing (LNS) is a measure of working memory. The participant is read a list of scrambled letters and numbers that they must then repeat back to the examiner in alphabetical and numeric order. The length of the target string increases over time until the participant is no longer able to correctly sequence three letter/ number stems in a row. We will utilize the LNS subscale from the Wechsler Intelligence Scale for Children, Fifth Edition (WISC-5; Wechsler, 2014) for participants between 12 and 16, and the Wechsler Adult Intelligence Scale (WAIS-IV; Wechsler, 2008) for particip
Baseline Assessment
Group
Value
95% CI
Computer-based Working Memory Training Program
9.14
± 1.2
Post-Training Assessment
Group
Value
95% CI
Computer-based Working Memory Training Program
9.86
± 2.7
Change in Iowa Gambling TaskPrimary· Baseline, 7 weeks
Iowa Gambling Task (IGT; Bechara et al., 1994) evaluates experiential decision making. It is administered via a computer interface, in which participants are presented four decks of cards and asked to select one deck to flip a card from in order to win money. Each deck is associated with specific winning and losing probabilities and performance on the task is determined by computing relative preference for longer vs. shorter-term rewards. Advantageous choices are summed and total scores range for -100 to +100 with higher scores indicating a higher proportion of advantageous choices suggesting
Baseline Assessment
Group
Value
95% CI
Computer-based Working Memory Training Program
42.3
± 23.7
Post-Training Assessment
Group
Value
95% CI
Computer-based Working Memory Training Program
46.3
± 26.5
Change in Youth Risk Behavior SurveySecondary· Baseline, 7 weeks
The Youth Risk Behavior Survey (YRBS; CDC, 2001) is a self-report measure of the prevalence of real world risk behaviors, including compromised safety behaviors (e.g. not wearing a seat belt), substance use, risky sexual practices, and delinquent behaviors (e.g. gambling, theft). Because substance use has been associated with problematic behaviors more broadly (Bukstein, 2000), the YRBS will allow us to tap engagement in a variety of related risky behaviors. We looked at changes in a single item assessing on how many of the last 30 days a participant had at least one sip of alcohol. Possible s
Baseline Assessment
Group
Value
95% CI
Computer-based Working Memory Training Program
0
± 0
Post-training Assessment
Group
Value
95% CI
Computer-based Working Memory Training Program
0
± 0
Change in Alcohol/Marijuana Effect ExpectanciesSecondary· Baseline, 7 weeks
The Alcohol Expectancy Questionnaire (AEQ; Brown, Christiansen, \& Goldman, 1987) and the Marijuana Effect Expectancy Questionnaire (MEEQ; Schafer \& Brown, 1991) are self-report questionnaires that tap youths' perception of positive and negative outcomes related to using alcohol and marijuana. Both measures report on youth positive (AEQ-positive - 4 items; MEEQ-positive - 3 items) and negative (AEQ-negative - 3 items, MEEQ-negative - 3 items) expectations. Each item is ranked on a 5-point Likert scale (1=disagree strongly to 5=agree strongly) and summed. Scores on the AEQ-positive range from
AEQ-positive Baseline Assessment
Group
Value
95% CI
Computer-based Working Memory Training Program
7
± 1.9
AEQ-positive Post-Training Assessment
Group
Value
95% CI
Computer-based Working Memory Training Program
8.1
± 2.9
AEQ-negative Baseline Assessment
Group
Value
95% CI
Computer-based Working Memory Training Program
9.4
± 3.5
AEQ-negative Post-Training Assessment
Group
Value
95% CI
Computer-based Working Memory Training Program
10.1
± 3.6
MEEQ-positive Baseline Assessment
Group
Value
95% CI
Computer-based Working Memory Training Program
10.6
± 3.1
MEEQ-positive Post-Training Assessment
Group
Value
95% CI
Computer-based Working Memory Training Program
12.7
± 3.8
MEEQ-negative Baseline Assessment
Group
Value
95% CI
Computer-based Working Memory Training Program
7.6
± 1.9
MEEQ-negative Post-Training Assessment
Group
Value
95% CI
Computer-based Working Memory Training Program
8.1
± 1.8
Sponsor's own description
The goal of this clinical trial is to pilot a computer-based working memory training program to improve delay discounting (DD) and prevent substance use among at-risk adolescents in a traditionally underserved area. Results from the study will inform future efforts substance use prevention efforts targeted at youth exposed to adverse childhood experiences. Findings will also refine future models of intervention delivery in traditionally underserved communities.
The main question\[s\] it aims to answer are:
* Determine if the intervention can be delivered feasibly, acceptability, and at sufficient dosage
* Evaluate the utility of the recruitment and retention procedures as well as identify barriers to participation
Publications & conference data
No peer-reviewed publications indexed yet for this trial. Completed trials usually publish results within 12-18 months.
Drug + disease cross-links: matched in real time against Drug Landscape's normalised drug + company + condition tables
Sponsor: as reported to ClinicalTrials.gov by Henry Ford Health System
Last refreshed: 28 March 2025
Drug Landscape aggregates and links these public records for informational use only. Always verify against the primary source before clinical or regulatory decisions. Canonical URL: https://druglandscape.com/trial/NCT05879198.