NCT05877261 is a clinical trial of Cementless Total Knee Replacement in Knee Arthroplasty, Total, sponsored by London Health Sciences Centre Research Institute OR Lawson Research Institute of St. Joseph's.

What drugs are being tested in NCT05877261?

Interventions in NCT05877261: Cementless Total Knee Replacement.

What condition does NCT05877261 study?

NCT05877261 studies Knee Arthroplasty, Total, Knee Osteoarthritis, Radiostereometric Analysis.

Is NCT05877261 still recruiting?

NCT05877261 is currently completed. Last updated 17 March 2025.

Last reviewed 2025-03-17 · How we verify

NCT05877261

Name: Drug Landscape Pharmaceutical Database
Creator: Drug Landscape
Published: 2026-01-01
License: https://creativecommons.org/licenses/by/4.0/

Cementless Triathlon 5YR Follow-Up

Completed Last updated 17 March 2025

What this trial tests

trial testing Cementless Total Knee Replacement in Knee Arthroplasty, Total in 18 participants. Completed in 31 December 2024.

Timeline

25 May 2023

Primary endpoint
1 April 2024

31 December 2024

Quick facts

Lead sponsor	London Health Sciences Centre Research Institute OR Lawson Research Institute of St. Joseph's
Status	Completed
Study type	OBSERVATIONAL
Enrollment	18
Start date	25 May 2023
Primary completion	1 April 2024
Estimated completion	31 December 2024
Sites	1 location across Canada

Drugs / interventions tested

Cementless Total Knee Replacement

Conditions studied

Knee Arthroplasty, Total — all drugs for Knee Arthroplasty, Total →
Knee Osteoarthritis — all drugs for Knee Osteoarthritis →
Radiostereometric Analysis — all drugs for Radiostereometric Analysis →

Sponsor

London Health Sciences Centre Research Institute OR Lawson Research Institute of St. Joseph's

Who can join

Adults 21 to 90, any sex, with Knee Arthroplasty, Total or Knee Osteoarthritis. Patients with the condition only — healthy volunteers not accepted.

Sponsor's own description

All artificial joint implants need to be solidly held (fixed) within the bone. Cementless fixation has become a popular method to achieve fixation for total knee replacements where the bone grows directly onto the implanted device instead of using bone cement. The primary purpose of this study is to assess long-term implant survivorship and clinical outcomes of a previous study cohort that received a cementless knee replacement. As this study cohort approaches 5 years post-operation, the investigators will re-examine the stability of participant implants using specialized x-rays, called "radiostereometric analysis". The study will use weight-bearing computed tomography (CT) to measure bone density and texture features and correlate that with implant stability. The investigators will collect stool samples to assess participant gut microbiomes for biomarkers of poor bone quality that could correlate to implant stability. All 33 participants from the original study cohort will be invited to participate in this study.

Publications & conference data

1 peer-reviewed publication reference this trial (live from Europe PMC):

Inducible displacement of cementless total knee arthroplasty components with conventional and weight-bearing CT-based radiostereometric analysis.
Hext RA, Kaptein BL, Howard JL, Lanting BA, et al · · 2025 · cited 5× · PMID 39545647 · DOI 10.1002/jor.26017

Verify or expand the search:

Other recruiting trials for Knee Arthroplasty, Total

Currently open trials in the same condition.

NCT07526831 — Comparison of the Analgesic Efficacy of Adductor Canal Block and Combined Adductor Canal Block Plus IPACK Block in Knee · recruiting
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NCT07089251 — The Perioperative Outcome of Epinephrine Infusion and Tranexamic Acid in Knee Arthroplasty Surgery · Phase 4 · recruiting

Other London Health Sciences Centre Research Institute OR Lawson Research Institute of St. Joseph's trials

Trials by the same sponsor.

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NCT07585292 — Transcutaneous Auricular Vagus Nerve Stimulation as a Treatment for Musculoskeletal Pain in Cerebral Palsy · NA · not yet recruiting
NCT07510906 — Evaluation of a Prostate-Targeted PET Imaging System (P-PET) for Detecting Prostate Cancer · NA · not yet recruiting
NCT03166072 — Health Education vs Meditation in Irreversible Age-Related Vision Loss Patients and Their Caregivers · NA · not yet recruiting
NCT06035809 — Sensory Motor Arousal Regulation Treatment (SMART) Study · NA · not yet recruiting

Verify against primary sources

ClinicalTrials.gov — authoritative US registry record
WHO ICTRP — international registry index
EU Clinical Trials Register
Sponsor press releases (Google)

Data sources for this page

Trial protocol + status: ClinicalTrials.gov NCT05877261 (US National Library of Medicine, public domain)
Publications: Europe PMC API search by NCT ID, retrieved 10 June 2026
Drug + disease cross-links: matched in real time against Drug Landscape's normalised drug + company + condition tables
Sponsor: as reported to ClinicalTrials.gov by London Health Sciences Centre Research Institute OR Lawson Research Institute of St. Joseph's
Last refreshed: 17 March 2025

Drug Landscape aggregates and links these public records for informational use only. Always verify against the primary source before clinical or regulatory decisions. Canonical URL: https://druglandscape.com/trial/NCT05877261.

Primary sources · FDA · ClinicalTrials.gov · EMA · SEC EDGAR · ChEMBL · Wikidata · full sourcing