Who is sponsoring NCT07425457?

NCT07425457 is sponsored by Attikon Hospital.

What drugs are being tested in NCT07425457?

Interventions in NCT07425457: CT-guided Cryoneurolysis of the Genicular Nerves.

What condition does NCT07425457 study?

NCT07425457 studies Arthroplasty, Replacement Material, Knee Arthritis Osteoarthritis, Knee Arthroplasty, Total, Genicular Nerves, Chronic Pain.

Is NCT07425457 still recruiting?

NCT07425457 is currently recruiting now. Last updated 20 February 2026.

Last reviewed 2026-02-20 · How we verify

NCT07425457: CRYO-TKA

Name: Drug Landscape Pharmaceutical Database
Creator: Drug Landscape
Published: 2026-01-01
License: https://creativecommons.org/licenses/by/4.0/

Cryoneurolysis Prior to Total Knee Arthroplasty (CRYO-TKA Trial)

Recruiting now NA Last updated 20 February 2026

What this trial tests

NA trial testing CT-guided Cryoneurolysis of the Genicular Nerves in Arthroplasty in 100 participants. Currently enrolling.

Timeline

2 January 2026

Primary endpoint
31 December 2027

31 March 2028

Quick facts

Lead sponsor	Attikon Hospital
Phase	NA
Status	Recruiting now
Study type	INTERVENTIONAL
Allocation	randomized
Design	parallel
Masking	single
Primary purpose	treatment
Enrollment	100
Start date	2 January 2026
Primary completion	31 December 2027
Estimated completion	31 March 2028
Sites	1 location across Greece

Drugs / interventions tested

CT-guided Cryoneurolysis of the Genicular Nerves

Conditions studied

Arthroplasty — all drugs for Arthroplasty →
Replacement Material — all drugs for Replacement Material →
Knee Arthritis Osteoarthritis — all drugs for Knee Arthritis Osteoarthritis →
Knee Arthroplasty, Total — all drugs for Knee Arthroplasty, Total →

Sponsor

Attikon Hospital

Who can join

18 and older, any sex, with Arthroplasty or Replacement Material. Patients with the condition only — healthy volunteers not accepted.

Sponsor's own description

Approximately 20-30% of patients experience persistent pain after a Total Knee Arthroplasty (TKA). This study investigates whether percutaneous cryoneurolysis of genicular nerves can reduce pain and improve physical function when performed at least 24 hours before surgery. Participants will be randomized to receive either the cryoneurolysis procedure + TKA or TKA only. Results will be tracked for 6 months to see if the intervention improves long-term recovery and quality of life.

Publications & conference data

No peer-reviewed publications indexed yet for this trial.

Verify or expand the search:

Other recruiting trials for Arthroplasty

Currently open trials in the same condition.

NCT06323980 — INHANCE Stemless Reverse Shoulder IDE · NA · recruiting
NCT04848896 — Study to Evaluate the Safety and Effectiveness of the REAL INTELLIGENCE™ CORI™ in Total Knee Arthroplasty (TKA) Procedur · NA · recruiting
NCT04849884 — To Evaluate the Performance of the CORI™ KNEE TENSIONER as an Accessory to the CORI™ Surgical System. · NA · active not recruiting
NCT05190666 — Healthy Living After Knee Replacement · NA · active not recruiting

Other Attikon Hospital trials

Trials by the same sponsor.

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NCT06810700 — The Association Between Time in Range With Markers of Endothelial and Cardiovascular Function · not yet recruiting
NCT06978387 — The Association Between Glycemic Metrics and Cardiovascular Markers in Patients With Type 1 Diabetes. · active not recruiting
NCT06749613 — Digestive Enzyme Formulation Intervention in IBS Patients Who Previously Clinically Responded to Mediterranean LFD · NA · recruiting
NCT07467642 — A Neuromodulation Auditory System to Optimize Patient Experience During Dysfunctional Dialysis Access Endovascular Proce · NA · active not recruiting

Verify against primary sources

ClinicalTrials.gov — authoritative US registry record
WHO ICTRP — international registry index
EU Clinical Trials Register
Sponsor press releases (Google)

Data sources for this page

Trial protocol + status: ClinicalTrials.gov NCT07425457 (US National Library of Medicine, public domain)
Drug + disease cross-links: matched in real time against Drug Landscape's normalised drug + company + condition tables
Sponsor: as reported to ClinicalTrials.gov by Attikon Hospital
Last refreshed: 20 February 2026

Drug Landscape aggregates and links these public records for informational use only. Always verify against the primary source before clinical or regulatory decisions. Canonical URL: https://druglandscape.com/trial/NCT07425457.

Primary sources · FDA · ClinicalTrials.gov · EMA · SEC EDGAR · ChEMBL · Wikidata · full sourcing