NCT05874999: COPD-HIIT-AC

Acute Effects of Supramaximal High-Intensity Interval Training in People With COPD

Completed NA Last updated 7 June 2023

What this trial tests

NA trial testing Supramaximal High-Intensity Interval Training at 60% of MPO6 in COPD in 32 participants. Completed in 22 December 2022.

Timeline

7 March 2022

Primary endpoint
22 December 2022

22 December 2022

Quick facts

Lead sponsor	Umeå University
Phase	NA
Status	Completed
Study type	INTERVENTIONAL
Allocation	randomized
Design	crossover
Masking	none
Primary purpose	other
Enrollment	32
Start date	7 March 2022
Primary completion	22 December 2022
Estimated completion	22 December 2022
Sites	1 location across Sweden

Drugs / interventions tested

• Supramaximal High-Intensity Interval Training at 60% of MPO6
• Moderate-Intensity Continuous Training
• Supramaximal High-Intensity Interval Training at 80% of MPO6

Conditions studied

• COPD — all drugs for COPD →
• Healthy Older Adults — all drugs for Healthy Older Adults →

Sponsor

Umeå University

Who can join

40 and older, any sex, with COPD or Healthy Older Adults. Patients with the condition only — healthy volunteers not accepted.

Sponsor's own description

High-intensity exercise is essential for optimal development of cardiorespiratory fitness and health. This is, however, challenging for most people with chronic obstructive pulmonary disease (COPD) due to ventilatory limitations, leading to exercise at lower intensities accompanied by suboptimal stress on the cardiovascular and muscular system.

The aims of this cross-over trial is:

1. To compare the acute effects of short-duration supramaximal high-intensity interval training (HIIT) vs. traditional moderate-intensity continuous training (MICT) in people with COPD and matched healthy controls (HC).
2. To investigate the feasibility of supramaximal HIIT in people with COPD and matched HC.
3. To compare the cardiorespiratory demand, exercise intensity and symptoms during a modified Borg Cycle Strength Test (BCST) and a cardiopulmonary exercise test (CPET) in people with COPD and HC.

Publications & conference data

1 peer-reviewed publication reference this trial (live from Europe PMC):

1. The modified Borg cycle strength test (mBCST): Feasibility and physiological response in people with COPD and healthy older adults.
   De Brandt J, Jakobsson J, Hedlund M, Sandström T, et al · · 2026 · cited 1× · PMID 40638604 · DOI 10.1113/ep092151