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NCT05874583
Prevention of Bleeding in Total Joint Replacement: Combined Route Administration of Tranexamic Acid
NA trial testing Combined route administration of Tranexamic acid in Tranexamic Acid in 100 participants. Completed in 31 December 2022.
30 September 2022
Quick facts
| Lead sponsor | Mongi Slim Hospital |
|---|---|
| Phase | NA |
| Status | Completed |
| Study type | INTERVENTIONAL |
| Allocation | randomized |
| Design | parallel |
| Masking | quadruple |
| Primary purpose | prevention |
| Enrollment | 100 |
| Start date | 1 December 2021 |
| Primary completion | 30 September 2022 |
| Estimated completion | 31 December 2022 |
| Sites | 1 location across Tunisia |
Drugs / interventions tested
- Combined route administration of Tranexamic acid — full drug profile →
- Intravenous route Tranexamic acid injection — full drug profile →
Conditions studied
- Tranexamic Acid — all drugs for Tranexamic Acid →
- Arthroplasty, Replacement, Knee — all drugs for Arthroplasty, Replacement, Knee →
- Blood Transfusion — all drugs for Blood Transfusion →
- Arthroplasty, Replacement, Hip — all drugs for Arthroplasty, Replacement, Hip →
Sponsor
Mongi Slim Hospital
Who can join
18 and older, any sex, with Tranexamic Acid or Arthroplasty, Replacement, Knee. Patients with the condition only — healthy volunteers not accepted.
Sponsor's own description
The investigators aimed to compare two doses of intravenous (IV) tranexamic acid (TXA) with a combined single dose of topical and IV TXA on haemoglobin decline 24 hours after total joint arthroplasties. The investigators conducted randomized, double-blind trial. The participants were randomized to either intrvenous group receiving 2 doses of 1 gram TXA in intravenous route 3 hours apart, or a combined application group receiving the first 1 gram IV and the topical dose was 1.5 gram after reduction of the fascia.
Publications & conference data
No peer-reviewed publications indexed yet for this trial. Completed trials usually publish results within 12-18 months.
Verify or expand the search:
- PubMed search for NCT05874583
- Europe PMC full search
- ASCO Meeting Library
- ESMO Meeting Library
- bioRxiv preprints
- medRxiv preprints
- Google Scholar
Related trials
Other recruiting trials for Tranexamic Acid
Currently open trials in the same condition.
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- NCT07157631 — Efficacy and Safety of Tranexamic Acid in Adult Liver Transplantation---ESTA Trial · NA · recruiting
- NCT06657924 — Preoperative Tranexamic Acid (TXA) to Prevent Bleeding in Patients Undergoing Major Colorectal Surgery · Phase 2 · recruiting
Other Mongi Slim Hospital trials
Trials by the same sponsor.
- NCT06511427 — Difficult Airways Scores Validation Difficult Laryngoscopy and Mask Ventilation: Prospective and Evaluative Study · not yet recruiting
- NCT06676865 — Preoperative Prediction of Difficult Laryngoscopy in Diabetic Patients: Importance of the Palm Print Test · completed
- NCT06444737 — Contribution of Ondansetron to Preventing Post-Dural Puncture Headaches Following Spinal Anesthesia · NA · recruiting
- NCT06203353 — Evaluation of the Diaphragm Performance During Weaning From Mechanical Ventilation · unknown
- NCT06622096 — Evaluation of Lab Exams Accuracy in the Intensive Care Unit · completed
Verify against primary sources
- ClinicalTrials.gov — authoritative US registry record
- WHO ICTRP — international registry index
- EU Clinical Trials Register
- Sponsor press releases (Google)
- Trial protocol + status: ClinicalTrials.gov NCT05874583 (US National Library of Medicine, public domain)
- Drug + disease cross-links: matched in real time against Drug Landscape's normalised drug + company + condition tables
- Sponsor: as reported to ClinicalTrials.gov by Mongi Slim Hospital
- Last refreshed: 25 May 2023
Drug Landscape aggregates and links these public records for informational use only. Always verify against the primary source before clinical or regulatory decisions. Canonical URL: https://druglandscape.com/trial/NCT05874583.
Primary sources · FDA · ClinicalTrials.gov · EMA · SEC EDGAR · ChEMBL · Wikidata · full sourcing