Who is sponsoring NCT05868551?

NCT05868551 is sponsored by Universiteit Antwerpen.

What drugs are being tested in NCT05868551?

Interventions in NCT05868551: nodulectomy.

What condition does NCT05868551 study?

NCT05868551 studies Onchocercal Subcutaneous Nodule, Epilepsy, Virus.

Is NCT05868551 still recruiting?

NCT05868551 is currently status unknown. Last updated 22 May 2023.

Last reviewed 2023-05-22 · How we verify

NCT05868551

Name: Drug Landscape Pharmaceutical Database
Creator: Drug Landscape
Published: 2026-01-01
License: https://creativecommons.org/licenses/by/4.0/

Onchocerciasis-Associated Epilepsy, an Explorative Case-control Study

Status unknown Last updated 22 May 2023

What this trial tests

trial testing nodulectomy in Onchocercal Subcutaneous Nodule in 40 participants. Status unknown.

Timeline

1 June 2023

Primary endpoint
1 July 2024

31 December 2024

Quick facts

Lead sponsor	Universiteit Antwerpen
Status	Status unknown
Study type	OBSERVATIONAL
Enrollment	40
Start date	1 June 2023
Primary completion	1 July 2024
Estimated completion	31 December 2024
Sites	1 location across South Sudan

Drugs / interventions tested

nodulectomy

Conditions studied

Onchocercal Subcutaneous Nodule — all drugs for Onchocercal Subcutaneous Nodule →
Epilepsy — all drugs for Epilepsy →
Virus — all drugs for Virus →

Sponsor

Universiteit Antwerpen — full company profile →

Who can join

Adults 12 to 35, any sex, with Onchocercal Subcutaneous Nodule or Epilepsy. Patients with the condition only — healthy volunteers not accepted.

Sponsor's own description

This is an exploratory case control study with the aim to compare the Onchocerca volvulus virome between persons with onchocerciasis-associated epilepsy (OAE) and persons with onchocerciasis but without epilepsy. The main question we want to address is: Is there a virus contained in the O. volulus worm that may have a pathogenic role in causing OAE. In Maridi County, South Sudan, 20 persons with OAE with onchocerciasis nodules, and 20 age- and village-matched controls without OAE will be enrolled in a nodulectomy study.The adult O. volvulus worms will be extracted from the nodules and a viral metagenomic study of the worms. The O. volvulus virome of persons with and without OAE will be compared.

Publications & conference data

3 peer-reviewed publications reference this trial (live from Europe PMC):

The onchocerciasis hypothesis of nodding syndrome.
Colebunders R, Hadermann A, Siewe Fodjo JN. · · 2023 · cited 12× · PMID 37590176 · DOI 10.1371/journal.pntd.0011523
Onchocerciasis-associated epilepsy: an explorative case-control study with viral metagenomic analyses on <i> </i> <i>Onchocerca volvulus</i>.
Hadermann A, Jada SR, Sebit WJ, Deng T, et al · · 2023 · cited 1× · PMID 38439783 · DOI 10.12688/f1000research.138774.2
Onchocerciasis-associated epilepsy: an explorative case-control study with viral metagenomic analyses on Onchocerca volvulus
Hadermann A, Jada SR, Sebit WJ, Deng T, et al · · 2023 · DOI 10.12688/f1000research.138774.2

Verify or expand the search:

Other recruiting trials for Onchocercal Subcutaneous Nodule

Currently open trials in the same condition.

NCT06070116 — Safety and Efficacy of Novel Combination Regimens for Treatment of Onchocerciasis · Phase 2 · active not recruiting

Other Universiteit Antwerpen trials

Trials by the same sponsor.

NCT07407569 — Developing a First-void Urine-based Infection Model to Study HPV-specific Antibody-virion Interaction Before and After H · Phase 2 · recruiting
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NCT06962579 — The Effect of Personalized Exercise Interventions for the Prevention of Chemotherapy-induced Peripheral Neuropathy · NA · recruiting
NCT06999473 — Assessment and Treat Neglect Patients With a VR Application · NA · not yet recruiting
NCT07161531 — Test-retest Reliability of sEMG to Measure Fatigue in Adolescents · NA · recruiting

Verify against primary sources

ClinicalTrials.gov — authoritative US registry record
WHO ICTRP — international registry index
EU Clinical Trials Register
Sponsor press releases (Google)

Data sources for this page

Trial protocol + status: ClinicalTrials.gov NCT05868551 (US National Library of Medicine, public domain)
Publications: Europe PMC API search by NCT ID, retrieved 9 June 2026
Drug + disease cross-links: matched in real time against Drug Landscape's normalised drug + company + condition tables
Sponsor: as reported to ClinicalTrials.gov by Universiteit Antwerpen
Last refreshed: 22 May 2023

Drug Landscape aggregates and links these public records for informational use only. Always verify against the primary source before clinical or regulatory decisions. Canonical URL: https://druglandscape.com/trial/NCT05868551.

Primary sources · FDA · ClinicalTrials.gov · EMA · SEC EDGAR · ChEMBL · Wikidata · full sourcing