Last reviewed · How we verify
NCT05867381: SAPIA
Using Indoor Air Filtration to Slow Atherothrombosis Progression in Adults With Ischemic Heart Disease History
NA trial testing HEPA filtration in Air Pollution in 112 participants. Currently enrolling.
30 June 2027
Quick facts
| Lead sponsor | University of Southern California |
|---|---|
| Phase | NA |
| Status | Recruiting now |
| Study type | INTERVENTIONAL |
| Allocation | randomized |
| Design | crossover |
| Masking | double |
| Primary purpose | prevention |
| Enrollment | 112 |
| Start date | 11 July 2023 |
| Primary completion | 30 June 2027 |
| Estimated completion | 30 June 2027 |
| Sites | 1 location across United States |
Drugs / interventions tested
- HEPA filtration
- Sham filtration
Conditions studied
- Air Pollution — all drugs for Air Pollution →
- Atherosclerosis — all drugs for Atherosclerosis →
Sponsor
University of Southern California
Who can join
Adults 65 to 84, any sex, with Air Pollution or Atherosclerosis. Patients with the condition only — healthy volunteers not accepted.
Sponsor's own description
This double-blind, randomized, crossover trial aims to test the hypothesis that longer-term indoor air filtration intervention can slow atherothrombosis progression by reducing indoor fine particulate matter (PM2.5) exposure in adults with ischemic heart disease history.
Publications & conference data
1 peer-reviewed publication reference this trial (live from Europe PMC):
-
Fine particulate matter levels and HEPA filtration in Los Angeles homes during a wildland-urban-interface fire.
Chen R, Lin Y, Liao J, Qiu C, et al · · 2026 · PMID 41550628 · DOI 10.1038/s44407-025-00042-5
Verify or expand the search:
- PubMed search for NCT05867381
- Europe PMC full search
- ASCO Meeting Library
- ESMO Meeting Library
- bioRxiv preprints
- medRxiv preprints
- Google Scholar
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Other University of Southern California trials
Trials by the same sponsor.
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Verify against primary sources
- ClinicalTrials.gov — authoritative US registry record
- WHO ICTRP — international registry index
- EU Clinical Trials Register
- Sponsor press releases (Google)
- Trial protocol + status: ClinicalTrials.gov NCT05867381 (US National Library of Medicine, public domain)
- Publications: Europe PMC API search by NCT ID, retrieved 10 June 2026
- Drug + disease cross-links: matched in real time against Drug Landscape's normalised drug + company + condition tables
- Sponsor: as reported to ClinicalTrials.gov by University of Southern California
- Last refreshed: 1 August 2025
Drug Landscape aggregates and links these public records for informational use only. Always verify against the primary source before clinical or regulatory decisions. Canonical URL: https://druglandscape.com/trial/NCT05867381.
Primary sources · FDA · ClinicalTrials.gov · EMA · SEC EDGAR · ChEMBL · Wikidata · full sourcing