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NCT05423665: HEART
Speckle Tracking Echocardiography as a Tool for Early Diagnosis of Impaired Fetal Growth Twin Pregnancies
trial testing sample collection in Fetal Growth Restriction in 360 participants. Currently enrolling.
1 February 2027
Quick facts
| Lead sponsor | University Hospital, Ghent |
|---|---|
| Status | Recruiting now |
| Study type | OBSERVATIONAL |
| Enrollment | 360 |
| Start date | 22 June 2023 |
| Primary completion | 1 February 2027 |
| Estimated completion | 1 February 2028 |
| Sites | 3 locations across Belgium, Netherlands |
Drugs / interventions tested
- sample collection — full drug profile →
Conditions studied
- Fetal Growth Restriction — all drugs for Fetal Growth Restriction →
- Cardiac Remodeling, Ventricular — all drugs for Cardiac Remodeling, Ventricular →
- Placental Insufficiency — all drugs for Placental Insufficiency →
- Air Pollution — all drugs for Air Pollution →
Sponsor
University Hospital, Ghent
Who can join
Adults 18 to 45, female only, with Fetal Growth Restriction or Cardiac Remodeling, Ventricular. Patients with the condition only — healthy volunteers not accepted.
Sponsor's own description
In this project there are 2 time points during the pregnancy included, namely at 21 weeks and 30 weeks of gestation, to measure the predictive values of FGR, strain and strain rate. The fetal growth parameters will be collected at the same time points, to define the growth (differences) throughout gestation of both fetuses. A maternal blood sample will be taken at 21 weeks of gestation to identify the level of exposure to air pollution (black carbon) and the level of biochemical markers of placental dysfunction. Doppler ultrasounds will be used for antenatal identification of placenta insufficiency. At birth, umbilical cord blood and the placenta will be collected. The placenta will be examined, to identify morphological findings which are associated with FGR. The umbilical cord blood and placental biopsy will be used for the level of exposure to air pollution and the level of oxidative stress. One to three days after birth, neonatal strain and strain rate will be measured to define postnatal cardiac remodeling as well as the neonatal blood pressure as cardiovascular risk factor.
Publications & conference data
No peer-reviewed publications indexed yet for this trial.
Verify or expand the search:
- PubMed search for NCT05423665
- Europe PMC full search
- ASCO Meeting Library
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- bioRxiv preprints
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Currently open trials in the same condition.
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Verify against primary sources
- ClinicalTrials.gov — authoritative US registry record
- WHO ICTRP — international registry index
- EU Clinical Trials Register
- Sponsor press releases (Google)
- Trial protocol + status: ClinicalTrials.gov NCT05423665 (US National Library of Medicine, public domain)
- Drug + disease cross-links: matched in real time against Drug Landscape's normalised drug + company + condition tables
- Sponsor: as reported to ClinicalTrials.gov by University Hospital, Ghent
- Last refreshed: 26 September 2023
Drug Landscape aggregates and links these public records for informational use only. Always verify against the primary source before clinical or regulatory decisions. Canonical URL: https://druglandscape.com/trial/NCT05423665.
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