NCT05865405 (MS-CATCH) is a NA clinical trial of MS CATCH in Multiple Sclerosis, sponsored by University of California, San Francisco.

Who is sponsoring NCT05865405?

NCT05865405 is sponsored by University of California, San Francisco.

What drugs are being tested in NCT05865405?

Interventions in NCT05865405: MS CATCH.

What condition does NCT05865405 study?

NCT05865405 studies Multiple Sclerosis, MS, Depression.

Is NCT05865405 still recruiting?

NCT05865405 is currently active, enrolled. Last updated 15 October 2025.

Last reviewed 2025-10-15 · How we verify

NCT05865405: MS-CATCH

Name: Drug Landscape Pharmaceutical Database
Creator: Drug Landscape
Published: 2026-01-01
License: https://creativecommons.org/licenses/by/4.0/

A Closed Loop, Doctor to Patient, Mobile Application for Depression in People With Multiple Sclerosis

Active, enrolled NA Last updated 15 October 2025

What this trial tests

NA trial testing MS CATCH in Multiple Sclerosis in 100 participants. Participants enrolled and being followed up; not accepting new ones.

Timeline

1 August 2023

Primary endpoint
15 August 2026

15 August 2026

Quick facts

Lead sponsor	University of California, San Francisco
Phase	NA
Status	Active, enrolled
Study type	INTERVENTIONAL
Allocation	randomized
Design	crossover
Masking	single
Primary purpose	prevention
Enrollment	100
Start date	1 August 2023
Primary completion	15 August 2026
Estimated completion	15 August 2026
Sites	1 location across United States

Drugs / interventions tested

MS CATCH

Conditions studied

Multiple Sclerosis — all drugs for Multiple Sclerosis →
MS — all drugs for MS →
Depression — all drugs for Depression →

Sponsor

University of California, San Francisco

Who can join

Adults 18 to 80, any sex, with Multiple Sclerosis or MS. Patients with the condition only — healthy volunteers not accepted.

Sponsor's own description

The researchers want to find out if an electronic application called MS CATCH can enhance patients' and doctors' experiences during and in between clinical visits. MS CATCH is a smartphone-based tool which allows patients to enter their mood related symptoms at regular intervals, which is then available to their Neurologist in their electronic medical record. The neurologist is also able to view additional information from their medical record, and receives alerts for changes reported by the patient that raise concern for the patient's mental health.

Publications & conference data

2 peer-reviewed publications reference this trial (live from Europe PMC):

A Closed-Loop Digital Health Tool to Improve Depression Care in Multiple Sclerosis: Iterative Design and Cross-Sectional Pilot Randomized Controlled Trial and its Impact on Depression Care.
Henderson K, Reihm J, Koshal K, Wijangco J, et al · · 2024 · cited 2× · PMID 38488827 · DOI 10.2196/52809
Pragmatic phase II clinical trial to improve depression care in a real-world diverse MS cohort from an academic MS centre in Northern California: MS CATCH study protocol.
Henderson K, Reihm J, Koshal K, Wijangco J, et al · · 2024 · cited 2× · PMID 38401894 · DOI 10.1136/bmjopen-2023-077432

Verify or expand the search:

Other recruiting trials for Multiple Sclerosis

Currently open trials in the same condition.

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NCT07236684 — Identification of Factors Related to UI in Patients With MS and EMG Assessment of PFM Activity · recruiting
NCT07500727 — Skeletal Muscle Aging and Responsiveness in Aged People With MS · NA · recruiting

Other University of California, San Francisco trials

Trials by the same sponsor.

NCT05284773 — Screening for Acute Malnutrition · NA · withdrawn
NCT04634851 — Video Home Visits for Dietary Counselling · NA · not yet recruiting
NCT06065670 — Assessing Changes in Multi-parametric MRI in Patients With Acute Demyelinating Lesions Taking Clemastine Fumarate as a M · Phase 1, PHASE2 · not yet recruiting
NCT07534098 — Intervention for Hearing Health Among Native Americans · NA · not yet recruiting
NCT06960421 — Exercise-based Frailty Intervention in Lung Transplantation (XFIT) · NA · not yet recruiting

Verify against primary sources

ClinicalTrials.gov — authoritative US registry record
WHO ICTRP — international registry index
EU Clinical Trials Register
Sponsor press releases (Google)

Data sources for this page

Trial protocol + status: ClinicalTrials.gov NCT05865405 (US National Library of Medicine, public domain)
Publications: Europe PMC API search by NCT ID, retrieved 10 June 2026
Drug + disease cross-links: matched in real time against Drug Landscape's normalised drug + company + condition tables
Sponsor: as reported to ClinicalTrials.gov by University of California, San Francisco
Last refreshed: 15 October 2025

Drug Landscape aggregates and links these public records for informational use only. Always verify against the primary source before clinical or regulatory decisions. Canonical URL: https://druglandscape.com/trial/NCT05865405.

Primary sources · FDA · ClinicalTrials.gov · EMA · SEC EDGAR · ChEMBL · Wikidata · full sourcing