NCT05843526 (PISTI) is a NA clinical trial of Experimental healing abutment in Dental Implants, sponsored by University of Liege.

Who is sponsoring NCT05843526?

NCT05843526 is sponsored by University of Liege.

What drugs are being tested in NCT05843526?

Interventions in NCT05843526: Experimental healing abutment.

What condition does NCT05843526 study?

NCT05843526 studies Dental Implants, Soft Tissue Inflammation, Immunohistochemistry, Dental Implants, Single-Tooth, Histology, Dental Implantation.

Is NCT05843526 still recruiting?

NCT05843526 is currently completed. Last updated 6 May 2023.

Last reviewed 2023-05-06 · How we verify

NCT05843526: PISTI

Name: Drug Landscape Pharmaceutical Database
Creator: Drug Landscape
Published: 2026-01-01
License: https://creativecommons.org/licenses/by/4.0/

Influence of Implant Component Materials on Peri-implant Soft Tissue Horst Response.

Completed NA Last updated 6 May 2023

What this trial tests

NA trial testing Experimental healing abutment in Dental Implants in 68 participants. Completed in 1 October 2022.

Timeline

1 May 2019

Primary endpoint
1 May 2021

1 October 2022

Quick facts

Lead sponsor	University of Liege
Phase	NA
Status	Completed
Study type	INTERVENTIONAL
Allocation	randomized
Design	parallel
Masking	none
Primary purpose	prevention
Enrollment	68
Start date	1 May 2019
Primary completion	1 May 2021
Estimated completion	1 October 2022
Sites	1 location across Belgium

Drugs / interventions tested

Experimental healing abutment

Conditions studied

Dental Implants — all drugs for Dental Implants →
Soft Tissue Inflammation — all drugs for Soft Tissue Inflammation →
Immunohistochemistry — all drugs for Immunohistochemistry →
Dental Implants, Single-Tooth — all drugs for Dental Implants, Single-Tooth →

Sponsor

University of Liege

Who can join

18 and older, any sex, with Dental Implants or Soft Tissue Inflammation. Patients with the condition only — healthy volunteers not accepted.

Sponsor's own description

The aim of this study was to characterize the host-related response of peri-implant soft tissue induced by 3 different materials: titanium, resin and PEEK (polyetheretherketone) on man. The primary endpoint is to asses the histological data available: Histological analyses are carried out with immunohistology (CD68, CD3, CD20, macrophages), non decalcified histology to appreciate the structure of the peri implant soft tissues (Sulcus depth, junctional epithelium, connective tissue adhesion). Moreover: scanning electronic microscope (SEM) of the experimental abutment is performed to juge the cell adhesion on the abutment surface. The secondary endpoint is to assess clinical data, radiological bone remodeling regarding the different material. The hypothesis is that resin abutment lead to more inflammation than PEEK or titanium.

Publications & conference data

1 peer-reviewed publication reference this trial (live from Europe PMC):

Surface Topography Steer Soft Tissue Response and Antibacterial Function at the Transmucosal Region of Titanium Implant.
Safaei M, Mohammadi H, Beddu S, Mozaffari HR, et al · · 2024 · cited 2× · PMID 38828200 · DOI 10.2147/ijn.s461549

Verify or expand the search:

Other recruiting trials for Dental Implants

Currently open trials in the same condition.

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Verify against primary sources

ClinicalTrials.gov — authoritative US registry record
WHO ICTRP — international registry index
EU Clinical Trials Register
Sponsor press releases (Google)

Data sources for this page

Trial protocol + status: ClinicalTrials.gov NCT05843526 (US National Library of Medicine, public domain)
Publications: Europe PMC API search by NCT ID, retrieved 10 June 2026
Drug + disease cross-links: matched in real time against Drug Landscape's normalised drug + company + condition tables
Sponsor: as reported to ClinicalTrials.gov by University of Liege
Last refreshed: 6 May 2023

Drug Landscape aggregates and links these public records for informational use only. Always verify against the primary source before clinical or regulatory decisions. Canonical URL: https://druglandscape.com/trial/NCT05843526.

Primary sources · FDA · ClinicalTrials.gov · EMA · SEC EDGAR · ChEMBL · Wikidata · full sourcing