Last reviewed · How we verify
NCT05842616
Cerebral Pulsatility Index Compared To Mean Arterial Blood Pressure Guided Protocol In Sepsis Induced Encephalopathy:
NA trial testing Transcranial doppler pulsatility index guided protocol in Sepsis in 112 participants. Completed in 30 June 2024.
30 June 2024
Quick facts
| Lead sponsor | Tanta University |
|---|---|
| Phase | NA |
| Status | Completed |
| Study type | INTERVENTIONAL |
| Allocation | randomized |
| Design | parallel |
| Masking | none |
| Primary purpose | treatment |
| Enrollment | 112 |
| Start date | 1 May 2023 |
| Primary completion | 30 June 2024 |
| Estimated completion | 30 June 2024 |
| Sites | 1 location across Egypt |
Drugs / interventions tested
- Transcranial doppler pulsatility index guided protocol
- Mean arterial blood pressure guided protocol
Conditions studied
- Sepsis — all drugs for Sepsis →
- Norepinephrine — all drugs for Norepinephrine →
- Encephalopathy — all drugs for Encephalopathy →
Sponsor
Tanta University
Who can join
18 and older, any sex, with Sepsis or Norepinephrine. Patients with the condition only — healthy volunteers not accepted.
Sponsor's own description
The aim of our study is to compare between transcranial doppler pulsatility index and mean arterial blood pressure in guiding management of sepsis induced encephalopathy.
Publications & conference data
1 peer-reviewed publication reference this trial (live from Europe PMC):
-
Norepinephrine titration in patients with sepsis-induced encephalopathy: cerebral pulsatility index compared to mean arterial pressure guided protocol: randomized controlled trial.
Salem MS, Abosabaa MA, Abd El Ghafar MS, Ei-Gendy HMEM, et al · · 2025 · cited 5× · PMID 39755598 · DOI 10.1186/s12871-024-02814-0
Verify or expand the search:
- PubMed search for NCT05842616
- Europe PMC full search
- ASCO Meeting Library
- ESMO Meeting Library
- bioRxiv preprints
- medRxiv preprints
- Google Scholar
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Verify against primary sources
- ClinicalTrials.gov — authoritative US registry record
- WHO ICTRP — international registry index
- EU Clinical Trials Register
- Sponsor press releases (Google)
- Trial protocol + status: ClinicalTrials.gov NCT05842616 (US National Library of Medicine, public domain)
- Publications: Europe PMC API search by NCT ID, retrieved 10 June 2026
- Drug + disease cross-links: matched in real time against Drug Landscape's normalised drug + company + condition tables
- Sponsor: as reported to ClinicalTrials.gov by Tanta University
- Last refreshed: 6 August 2024
Drug Landscape aggregates and links these public records for informational use only. Always verify against the primary source before clinical or regulatory decisions. Canonical URL: https://druglandscape.com/trial/NCT05842616.
Primary sources · FDA · ClinicalTrials.gov · EMA · SEC EDGAR · ChEMBL · Wikidata · full sourcing