NCT05833087: DEPRE-ST

Schema Therapy for Patients With Chronic Treatment Resistant Depression

Recruiting now NA Last updated 23 September 2025

What this trial tests

NA trial testing Schema therapy in Treatment Resistant Depression in 129 participants. Currently enrolling.

Timeline

17 April 2023

Primary endpoint
31 July 2029

31 July 2029

Quick facts

Lead sponsor	Region of Southern Denmark
Phase	NA
Status	Recruiting now
Study type	INTERVENTIONAL
Allocation	randomized
Design	parallel
Masking	single
Primary purpose	treatment
Enrollment	129
Start date	17 April 2023
Primary completion	31 July 2029
Estimated completion	31 July 2029
Sites	6 locations across Denmark

Drugs / interventions tested

• Schema therapy
• Other psychotherapy
• Standard care package content

Conditions studied

• Treatment Resistant Depression — all drugs for Treatment Resistant Depression →
• Chronic Depression — all drugs for Chronic Depression →

Sponsor

Region of Southern Denmark

Who can join

Adults 18 to 65, any sex, with Treatment Resistant Depression or Chronic Depression. Patients with the condition only — healthy volunteers not accepted.

Sponsor's own description

The goal of this clinical study is to test a particular form of psychotherapy, called schema therapy, for people with difficult-to-treat depression (when depression is very lengthy or difficult to cure with antidepressive medication). Researchers will compare the group of participants receiving schema therapy to a group receiving standard psychotherapeutic treatment to see if schema therapy is more effective on depression symptoms and other important issues for the participant.

The main question the study aims to answer is:

\- Can schema therapy be a more effective treatment for difficult-to-treat depression than other forms of psychotherapy offered in psychiatry today?

People who have difficult-to-treat depression are a special group of patients who are more strained in a wide range of areas of life than other people with depression. They also more often have childhood trauma, as well as simultaneous personality disorder or personality traits that brings challenges in everyday life. Currently we can not offer a sufficiently effective psychiatric treatment for this group of people.

Schema therapy was developed to help patients who do not have sufficient effect of the usual psychotherapeutic treatments. It also addresses personality disorders or problematic traits and childhood trauma directly in the therapy.

The project will include 129 participants in total, of which half will receive schema therapy.

Treatment is provided at six psychiatric centers in both the Southern and the Capital Regions of Denmark.

Participants receiving schema therapy will be given 30 sessions of weekly therapy, as well as the opportunity for the rest of the standard care package in the Danish secondary mental health system, that is, treatment with psychopharmacological medicine and meetings with next-to-kin and other parts of the participant's support system.

Participants receiving the standard treatment will receive about 6-20 sessions of individual or group therapy with a range of other psychotherapies that are not schema therapy, as well as the other parts of the standard care package as listed above.

If schema therapy proves to be more effective for treatment of difficult-to-treat depression than the treatment offered today, it may give rise to more extended use of schema therapy in and outside psychiatry. This means that the toolbox for the treatment of difficult-to-treat depression is expanded with a new specialized and effective psychotherapeutic tool.

Publications & conference data

4 peer-reviewed publications reference this trial (live from Europe PMC):

1. Schema therapy versus treatment as usual for outpatients with difficult-to-treat depression: study protocol for a parallel group randomized clinical trial (DEPRE-ST).
   Arendt ITP, Gondan M, Juul S, Hastrup LH, et al · · 2024 · cited 2× · PMID 38627837 · DOI 10.1186/s13063-024-08079-9
2. Statistical analysis plan for a parallel group randomized clinical trial comparing schema therapy versus treatment as usual for outpatients with difficult-to-treat depression (DEPRE-ST).
   Arendt ITP, Gondan M, Juul S, Hastrup LH, et al · · 2025 · PMID 40890784 · DOI 10.1186/s13063-025-09012-4
3. Statistical analysis plan for a parallel group randomized clinical trial comparing schema therapy versus treatment as usual for outpatients with difficult-to-treat depression (DEPRE-ST)
   Arendt ITP, Gondan M, Juul S, Hastrup LH, et al · · 2025 · DOI 10.21203/rs.3.rs-7046883/v1
4. Schema therapy versus treatment as usual for outpatients with difficult-to-treat depression: study protocol for a parallel group randomized clinical trial (DEPRE-ST)
   Arendt ITP, Gondan M, Juul S, Hastrup LH, et al · · 2024 · DOI 10.21203/rs.3.rs-3860859/v1