NCT05828043 is a NA clinical trial of Multi-domain intervention in Age-related Cognitive Decline, sponsored by National Yang Ming Chiao Tung University.

Who is sponsoring NCT05828043?

NCT05828043 is sponsored by National Yang Ming Chiao Tung University.

What drugs are being tested in NCT05828043?

Interventions in NCT05828043: Multi-domain intervention.

What condition does NCT05828043 study?

NCT05828043 studies Age-related Cognitive Decline, Age-related Physiology Decline.

Is NCT05828043 still recruiting?

NCT05828043 is currently completed. Last updated 26 December 2023.

Last reviewed 2023-12-26 · How we verify

NCT05828043

Name: Drug Landscape Pharmaceutical Database
Creator: Drug Landscape
Published: 2026-01-01
License: https://creativecommons.org/licenses/by/4.0/

Brain Aging: Muscle-to-brain Axis Modulates Physio-cognitive Decline

Completed NA Last updated 26 December 2023

What this trial tests

NA trial testing Multi-domain intervention in Age-related Cognitive Decline in 102 participants. Completed in 30 July 2023.

Timeline

1 November 2021

Primary endpoint
30 July 2023

30 July 2023

Quick facts

Lead sponsor	National Yang Ming Chiao Tung University
Phase	NA
Status	Completed
Study type	INTERVENTIONAL
Allocation	randomized
Design	parallel
Masking	none
Primary purpose	treatment
Enrollment	102
Start date	1 November 2021
Primary completion	30 July 2023
Estimated completion	30 July 2023
Sites	1 location across Taiwan

Drugs / interventions tested

Multi-domain intervention

Conditions studied

Age-related Cognitive Decline — all drugs for Age-related Cognitive Decline →
Age-related Physiology Decline — all drugs for Age-related Physiology Decline →

Sponsor

National Yang Ming Chiao Tung University

Who can join

65 and older, any sex, with Age-related Cognitive Decline or Age-related Physiology Decline. Patients with the condition only — healthy volunteers not accepted.

Sponsor's own description

The primary goal is to develop a multidomain intervention program focused on preserving global or regional brain volume and functions while simultaneously improving physical mobility and cognitive functions in older individuals with mobility frailty. This initiative seeks to unravel the brain-muscle axis mechanisms contributing to the accelerated functional declines observed in older populations. Moreover, our objective includes examining the relationships between the intervention and a broad spectrum of clinical characteristics, phenotypic traits, biochemical profiles, myokines, proteomics, metabolomics, brain imaging, and our previously identified discoveries involving exosomal miRNA.

Publications & conference data

1 peer-reviewed publication reference this trial (live from Europe PMC):

Enhancing Neurocognitive Health via Activity, Nutrition and Cognitive Exercise (ENHANCE): A Randomized Controlled Trial.
Peng LN, Lee PL, Chou KH, Lee WJ, et al · · 2025 · cited 2× · PMID 40464147 · DOI 10.1002/jcsm.13830

Verify or expand the search:

Other trials of Multi-domain intervention

Trials testing the same drug.

NCT03528005 — Effectiveness of Integrated Care Network · NA · completed
NCT04440969 — Evaluation of Pilot Community-based Multi-domain Program Older Adults at Risk of Cognitive Impairment · NA · completed

Other recruiting trials for Age-related Cognitive Decline

Currently open trials in the same condition.

NCT06948136 — Acute Effects of THC in Older Adult · Phase 1 · recruiting
NCT06964399 — The Effect of Reminiscence Therapy in Elderly · NA · recruiting
NCT06893432 — Cognitive Function and EEG Brain Network Remodeling Among Users of Hearing Aids With ARHL · active not recruiting
NCT06377254 — Multi-organ Responses to CHronic Physical Activity and INactivity · NA · recruiting
NCT04184375 — Cognitive Stimulation for Elderly Bipolar Patients · NA · recruiting

Other National Yang Ming Chiao Tung University trials

Trials by the same sponsor.

NCT07448857 — Kinematics and Muscle Activation of Scapula in Upper String Players With Neck Pain · recruiting
NCT07318454 — Comparison of Abdominal Expansion and Abdominal Drawing-In Training With Manual and Verbal Cueing in Chronic Non-Specifi · NA · not yet recruiting
NCT07494461 — Inhibitory Control and Gait Adaptability in Parkinson's Disease · not yet recruiting
NCT07494487 — Reliability of Community Ambulation Ability, Fall Risk, and Dynamic Visual Acuity Assessments in Stroke · not yet recruiting
NCT07494500 — Vestibular Training on Community Ambulation and Fall Risk in Stroke · NA · not yet recruiting

Verify against primary sources

ClinicalTrials.gov — authoritative US registry record
WHO ICTRP — international registry index
EU Clinical Trials Register
Sponsor press releases (Google)

Data sources for this page

Trial protocol + status: ClinicalTrials.gov NCT05828043 (US National Library of Medicine, public domain)
Publications: Europe PMC API search by NCT ID, retrieved 10 June 2026
Drug + disease cross-links: matched in real time against Drug Landscape's normalised drug + company + condition tables
Sponsor: as reported to ClinicalTrials.gov by National Yang Ming Chiao Tung University
Last refreshed: 26 December 2023

Drug Landscape aggregates and links these public records for informational use only. Always verify against the primary source before clinical or regulatory decisions. Canonical URL: https://druglandscape.com/trial/NCT05828043.

Primary sources · FDA · ClinicalTrials.gov · EMA · SEC EDGAR · ChEMBL · Wikidata · full sourcing