NCT05793359 is a clinical trial of Methylprednisolone in Graves Ophthalmopathy, sponsored by Medical University of Sofia.

Who is sponsoring NCT05793359?

NCT05793359 is sponsored by Medical University of Sofia.

What drugs are being tested in NCT05793359?

Interventions in NCT05793359: Methylprednisolone.

What condition does NCT05793359 study?

NCT05793359 studies Graves Ophthalmopathy.

Is NCT05793359 still recruiting?

NCT05793359 is currently completed. Last updated 31 March 2023.

Last reviewed 2023-03-31 · How we verify

NCT05793359

Name: Drug Landscape Pharmaceutical Database
Creator: Drug Landscape
Published: 2026-01-01
License: https://creativecommons.org/licenses/by/4.0/

Comparison of the Effectiveness of Two Glucocorticoid Regimens for Treatment of Graves' Orbitopathy

Completed Last updated 31 March 2023

What this trial tests

trial testing Methylprednisolone in Graves Ophthalmopathy in 62 participants. Completed in 25 February 2021.

Timeline

25 July 2017

Primary endpoint
25 February 2021

25 February 2021

Quick facts

Lead sponsor	Medical University of Sofia
Status	Completed
Study type	OBSERVATIONAL
Enrollment	62
Start date	25 July 2017
Primary completion	25 February 2021
Estimated completion	25 February 2021
Sites	1 location across Bulgaria

Drugs / interventions tested

Methylprednisolone (methylprednisolone) — full drug profile →

Conditions studied

Graves Ophthalmopathy — all drugs for Graves Ophthalmopathy →

Sponsor

Medical University of Sofia

Who can join

18 and older, any sex, with Graves Ophthalmopathy. Patients with the condition only — healthy volunteers not accepted.

Sponsor's own description

The goal of this interventional study is to compare the effectiveness of two different glucocorticoid regimens for treatment of active moderate-to-severe Graves' orbitopathy. The main questions it aims to answer are: 1. Are the two glucocorticoid regimens similarly effective? 2. Do the two glucocorticoid regimens have similar safety profile? The patients involved are treated with one of the two glucocorticoid regimens. Their ocular status, therapeutic response and quality of life reassessed during the treatment, at its end, and 3 month later.

Publications & conference data

1 peer-reviewed publication reference this trial (live from Europe PMC):

Comparison of the efficacy of two different glucocorticoid regimens for treatment of active moderate-to-severe Graves' orbitopathy.
Stoynova MA, Shinkov AD, Dimitrova ID, Yankova IA, et al · · 2023 · cited 2× · PMID 37698660 · DOI 10.1007/s10792-023-02875-z

Verify or expand the search:

Other trials of Methylprednisolone

Trials testing the same drug.

NCT07072585 — Testing the Addition of Daratumumab to Chemotherapy for Treating Patients With Newly-Diagnosed T-Cell Lymphoblastic Leuk · Phase 2, PHASE3 · not yet recruiting
NCT07455396 — Pediatric Asthma Trial of Corticosteroid Heterogeneity (PATCH): Trial of Dexamethasone Versus Methylprednisolone for Ped · Phase 2 · not yet recruiting
NCT07507643 — A Study of Methylprednisolone in People Having Liver Surgery · Phase 3 · recruiting
NCT07357935 — Early Inflammatory-Immune Stratification and Precision Glucocorticoid Intervention in Acute Respiratory Failure Induced · Phase 1, PHASE2 · not yet recruiting
NCT07265258 — A Study of Teprotumumab N01 in Subjects With Active Thyroid Eye Disease · Phase 4 · not yet recruiting

Other recruiting trials for Graves Ophthalmopathy

Currently open trials in the same condition.

NCT07480720 — Systemic Inflammation, Thyroid Autoimmunity and Neuroretinal Changes in Graves Disease · recruiting
NCT05126147 — Hydroxychloroquine in Mild Graves' Orbitopathy · Phase 4 · recruiting
NCT06275373 — The Effect of Teprotumumab on Thyroid Eye Disease and Thyroid Dysfunction · recruiting
NCT05678374 — Exploring Immunological Markers Associated With Mental Fatigue in Graves' Disease · recruiting
NCT03131726 — Treatment of Graves´ophthalmopathy with Simvastatin (GO-S) · Phase 3 · recruiting

Other Medical University of Sofia trials

Trials by the same sponsor.

NCT07493278 — Er,Cr:YSGG Laser Versus Conventional Preparation for Minimally Invasive Caries Removal · NA · completed
NCT06974201 — The Effect of Diabetes M Application Use Versus Conventional Bolus Calculation in Patients With Type 1 Diabetes Mellitus · NA · active not recruiting
NCT07358429 — CPAP Therapy and Atrial Fibrillation Recurrence in OSA · active not recruiting
NCT06415825 — Preliminary Muscle Contraction in the Rehabilitation and Prevention of Degenerative Pain in the Locomotor System · NA · not yet recruiting
NCT07230522 — Effectiveness of Hyaluronic Acid (hyaDENT BG® Gel) Compared With Enamel Matrix Proteins (Emdogain®) in the Treatment of · NA · completed

Verify against primary sources

ClinicalTrials.gov — authoritative US registry record
WHO ICTRP — international registry index
EU Clinical Trials Register
Sponsor press releases (Google)

Data sources for this page

Trial protocol + status: ClinicalTrials.gov NCT05793359 (US National Library of Medicine, public domain)
Publications: Europe PMC API search by NCT ID, retrieved 10 June 2026
Drug + disease cross-links: matched in real time against Drug Landscape's normalised drug + company + condition tables
Sponsor: as reported to ClinicalTrials.gov by Medical University of Sofia
Last refreshed: 31 March 2023

Drug Landscape aggregates and links these public records for informational use only. Always verify against the primary source before clinical or regulatory decisions. Canonical URL: https://druglandscape.com/trial/NCT05793359.

Primary sources · FDA · ClinicalTrials.gov · EMA · SEC EDGAR · ChEMBL · Wikidata · full sourcing