Last reviewed · How we verify
NCT03131726
Treatment of Graves´ophthalmopathy with Simvastatin (GO-S)
Phase 3 trial testing Simvastatin 40mg in Graves Ophthalmopathy in 80 participants. Currently enrolling.
26 January 2027
Quick facts
| Lead sponsor | Lund University |
|---|---|
| Phase | Phase 3 |
| Status | Recruiting now |
| Study type | INTERVENTIONAL |
| Allocation | randomized |
| Design | parallel |
| Masking | single |
| Primary purpose | treatment |
| Enrollment | 80 |
| Start date | 26 January 2018 |
| Primary completion | 26 January 2027 |
| Estimated completion | 30 March 2028 |
| Sites | 1 location across Sweden |
Drugs / interventions tested
- Simvastatin 40mg — full drug profile →
Conditions studied
- Graves Ophthalmopathy — all drugs for Graves Ophthalmopathy →
- Thyroid Associated Ophthalmopathy — all drugs for Thyroid Associated Ophthalmopathy →
- Thyroid Associated Orbitopathy — all drugs for Thyroid Associated Orbitopathy →
Sponsor
Lund University
Who can join
Adults 18 to 70, any sex, with Graves Ophthalmopathy or Thyroid Associated Ophthalmopathy. Patients with the condition only — healthy volunteers not accepted.
Sponsor's own description
In an investigator initiated multicenter trial (Malmö, Odense, Århus) the investigators aim at evaluating activity of Graves´ophthalmopathy (GO) and progress to severe GO in patients with mild to moderate Graves´ ophthalmopathy treated with simvastatin or no treatment.
Publications & conference data
1 peer-reviewed publication reference this trial (live from Europe PMC):
-
Newly Developed Prodrugs and Prodrugs in Development; an Insight of the Recent Years.
Najjar A, Najjar A, Karaman R. · · 2020 · cited 39× · PMID 32079289 · DOI 10.3390/molecules25040884
Verify or expand the search:
- PubMed search for NCT03131726
- Europe PMC full search
- ASCO Meeting Library
- ESMO Meeting Library
- bioRxiv preprints
- medRxiv preprints
- Google Scholar
Related trials
Other trials of Simvastatin 40mg
Trials testing the same drug.
- NCT06379958 — Drug-Drug Interaction (DDI) Study of Leramistat in Healthy Adult Subjects · Phase 1 · recruiting
- NCT05586360 — T-reg Function Changes: a Novel Immune Regulatory Effect Underlying Benefit of Statin Use on Lethal Prostate Cancer · Phase 2 · recruiting
- NCT04457089 — Statin Therapy to Reduce Progression in Women With Platinum Sensitive Ovarian Cancer · EARLY_PHASE1 · completed
- NCT03654053 — Multi-Center Study of the Effects of Simvastatin on Hepatic Decompensation and Death in Subjects Presenting With High-Ri · Phase 3 · active not recruiting
- NCT04133792 — Effect of Simvastatin on the Prognosis of Primary Primary Sclerosing Cholangitis (PSC) · Phase 3 · active not recruiting
Other recruiting trials for Graves Ophthalmopathy
Currently open trials in the same condition.
- NCT07480720 — Systemic Inflammation, Thyroid Autoimmunity and Neuroretinal Changes in Graves Disease · recruiting
- NCT05126147 — Hydroxychloroquine in Mild Graves' Orbitopathy · Phase 4 · recruiting
- NCT06275373 — The Effect of Teprotumumab on Thyroid Eye Disease and Thyroid Dysfunction · recruiting
- NCT05678374 — Exploring Immunological Markers Associated With Mental Fatigue in Graves' Disease · recruiting
- NCT03708627 — Bimatoprost as a Treatment for Graves' Orbitopathy · EARLY_PHASE1 · recruiting
Other Lund University trials
Trials by the same sponsor.
- NCT06661460 — Internet-Delivered Cognitive Behavioral Intervention for Youths With Anxiety Disorders · NA · recruiting
- NCT07425925 — Digital Peer-support-based Anti-HIV Stigma Intervention Among Adolescents Living With HIV in Ethiopia · NA · recruiting
- NCT07407842 — UPSIDES - Recovery Through Peer Support · NA · enrolling by invitation
- NCT07141108 — Self-monitoring and Remote Monitoring of Chronic Pain in Primary Care - Using a Digital Tool to Improve Quality of Life · NA · recruiting
- NCT07025694 — Exercise Training Among Children With Cerebral Palsy to Increase Health and Well-being - A Feasibility Study · NA · recruiting
Verify against primary sources
- ClinicalTrials.gov — authoritative US registry record
- WHO ICTRP — international registry index
- EU Clinical Trials Register
- Sponsor press releases (Google)
- Trial protocol + status: ClinicalTrials.gov NCT03131726 (US National Library of Medicine, public domain)
- Publications: Europe PMC API search by NCT ID, retrieved 10 June 2026
- Drug + disease cross-links: matched in real time against Drug Landscape's normalised drug + company + condition tables
- Sponsor: as reported to ClinicalTrials.gov by Lund University
- Last refreshed: 25 September 2024
Drug Landscape aggregates and links these public records for informational use only. Always verify against the primary source before clinical or regulatory decisions. Canonical URL: https://druglandscape.com/trial/NCT03131726.
Primary sources · FDA · ClinicalTrials.gov · EMA · SEC EDGAR · ChEMBL · Wikidata · full sourcing