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NCT05791721
Effect of Preemptive Etoricoxib and Dexamethasone on Wound Healing and Clinical Parameters After Third Molar Surgery
Phase 4 trial testing Etoricoxib 90 Mg Oral Tablet in Surgical Wound in 90 participants. Completed in 26 December 2022.
26 December 2022
Quick facts
| Lead sponsor | University of Belgrade |
|---|---|
| Phase | Phase 4 |
| Status | Completed |
| Study type | INTERVENTIONAL |
| Allocation | randomized |
| Design | parallel |
| Masking | triple |
| Primary purpose | prevention |
| Enrollment | 90 |
| Start date | 11 October 2021 |
| Primary completion | 26 December 2022 |
| Estimated completion | 26 December 2022 |
| Sites | 1 location across Serbia |
Drugs / interventions tested
- Etoricoxib 90 Mg Oral Tablet
- Dexamethasone 4mg — full drug profile →
Conditions studied
- Surgical Wound — all drugs for Surgical Wound →
- Post Operative Pain — all drugs for Post Operative Pain →
Sponsor
University of Belgrade
Who can join
Adults 18 to 30, any sex, with Surgical Wound or Post Operative Pain. Patients with the condition only — healthy volunteers not accepted.
Sponsor's own description
The goal of this clinical trial is to compare preemptive single-dose selective cyclooxygenase 2 (COX-2) inhibitor - etoricoxib and dexamethasone use in systemically healthy patients during the surgical extraction of impacted mandibular third molars. The main questions it aims to answer/evaluate are: * the level of inflammatory and early wound healing mediators in patients' saliva during early postoperative phase * clinical postoperative parameters such as pain, swelling and trismus * patient satisfaction with the treatment * rescue medication consumed during the postoperative period * incidence of adverse events Participants indicated for mandibular third molar surgery will be asked to: * take premedication (etoricoxib or dexamethasone) before surgical extraction * provide saliva samples before and following the surgery at regular check-ups * note the amount of rescue medication taken and pain intensity in different time points * perform clinical measurements of swelling and trismus at regular check-up visits * answer the questions about satisfaction and potential adverse events, if occur Researchers will compare preemptive single-dose etoricoxib, preemptive single-dose dexamethasone, and no premedication in impacted mandibular third molar surgery, to see if there are differences in inflammatory response and early wound healing, as well as in clinical postoperative parameters, patient satisfaction with the treatment and incidence of potential adverse events.
Publications & conference data
1 peer-reviewed publication reference this trial (live from Europe PMC):
-
Comparison of preemptive etoricoxib and dexamethasone in third molar surgery - a randomized controlled clinical trial of patient-reported and clinical outcomes.
Mijailovic I, Janjic B, Milicic B, Todorovic A, et al · · 2023 · cited 1× · PMID 37452140 · DOI 10.1007/s00784-023-05146-4
Verify or expand the search:
- PubMed search for NCT05791721
- Europe PMC full search
- ASCO Meeting Library
- ESMO Meeting Library
- bioRxiv preprints
- medRxiv preprints
- Google Scholar
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Verify against primary sources
- ClinicalTrials.gov — authoritative US registry record
- WHO ICTRP — international registry index
- EU Clinical Trials Register
- Sponsor press releases (Google)
- Trial protocol + status: ClinicalTrials.gov NCT05791721 (US National Library of Medicine, public domain)
- Publications: Europe PMC API search by NCT ID, retrieved 10 June 2026
- Drug + disease cross-links: matched in real time against Drug Landscape's normalised drug + company + condition tables
- Sponsor: as reported to ClinicalTrials.gov by University of Belgrade
- Last refreshed: 30 March 2023
Drug Landscape aggregates and links these public records for informational use only. Always verify against the primary source before clinical or regulatory decisions. Canonical URL: https://druglandscape.com/trial/NCT05791721.
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