Last reviewed · How we verify
NCT05782543: REWARM
Renal Ex Vivo Warm Advanced Resuscitation Through Machine Perfusion
NA trial testing Normothermic machine perfusion in Kidney Transplant; Complications in 240 participants. Currently enrolling.
1 December 2027
Quick facts
| Lead sponsor | University Medical Center Groningen |
|---|---|
| Phase | NA |
| Status | Recruiting now |
| Study type | INTERVENTIONAL |
| Allocation | randomized |
| Design | parallel |
| Masking | single |
| Primary purpose | treatment |
| Enrollment | 240 |
| Start date | 15 December 2024 |
| Primary completion | 1 December 2027 |
| Estimated completion | 1 May 2028 |
| Sites | 3 locations across Netherlands |
Drugs / interventions tested
- Normothermic machine perfusion
Conditions studied
- Kidney Transplant; Complications — all drugs for Kidney Transplant; Complications →
Sponsor
University Medical Center Groningen
Who can join
Adults 50 to 100, any sex, with Kidney Transplant; Complications. Patients with the condition only — healthy volunteers not accepted.
Sponsor's own description
The REWARM study is a randomized controlled clinical efficacy study, with primary outcome renal function 12 months after transplantation of kidneys recovered from deceased donors aged 50 years or older. Prior to transplantation, kidney grafts in the intervention group will receive 6 hours of NMP, following standard HMP and kidneys in the control group will only receive standard treatment, being HMP. It is a multi-center trial. Given the total annual 50+ deceased donor kidney transplantation volume of the three participating transplant centers combined, inclusions in the study are expected to last 2.5-3 years, aiming for a total of 120 patients in each of the two arms (240 patients total).
Publications & conference data
1 peer-reviewed publication reference this trial (live from Europe PMC):
-
Kidney Preservation Strategies to Improve Transplant Outcomes.
Longchamp A, Markmann JF. · · 2023 · cited 2× · PMID 37219010 · DOI 10.2215/cjn.0000000000000212
Verify or expand the search:
- PubMed search for NCT05782543
- Europe PMC full search
- ASCO Meeting Library
- ESMO Meeting Library
- bioRxiv preprints
- medRxiv preprints
- Google Scholar
Related trials
Other trials of Normothermic machine perfusion
Trials testing the same drug.
- NCT05743751 — Normothermic Machine Perfusion (NMP) Versus Hypothermic Machine Perfusion (HMP) in Human Kidney Transplantation · NA · unknown
Other recruiting trials for Kidney Transplant; Complications
Currently open trials in the same condition.
- NCT07531966 — Vascular Complications After Kidney Transplantation · recruiting
- NCT06958796 — Strategic Help With Immunoglobulin to Enhance Protect Against Late Disease (CMV) · Phase 4 · recruiting
- NCT06798909 — Kidney Transplant Preemptive Therapy or Prophylaxis for CMV Prevention in D+R Recipients · Phase 3 · recruiting
- NCT07033858 — Evaluaion the Short Term Effects of Advograf Plus Rapamiune After Kidney Transplantation · NA · recruiting
- NCT06059664 — The EFfect of FinErenone in Kidney TransplantiOn Recipients: The EFFEKTOR Study · Phase 2 · recruiting
Other University Medical Center Groningen trials
Trials by the same sponsor.
- NCT06647602 — Thyroid Hormone Replacement After Radio Iodine: Value and Efficacy · not yet recruiting
- NCT06809946 — Feasibility of Fluorescence Imaging With Bevacizumab-800CW During Bronchoscopy · Phase 2 · not yet recruiting
- NCT07527390 — CANagliflozin In DIALysis Patients · Phase 4 · not yet recruiting
- NCT07439237 — Implant-supported Maxillary Overdentures; a 15-years Evaluation · not yet recruiting
- NCT07275437 — Effectiveness and Safety of Uptitration of Guideline Directed MEdical Therapy in Heart Failure With Reduced Ejection Fra · NA · not yet recruiting
Verify against primary sources
- ClinicalTrials.gov — authoritative US registry record
- WHO ICTRP — international registry index
- EU Clinical Trials Register
- Sponsor press releases (Google)
- Trial protocol + status: ClinicalTrials.gov NCT05782543 (US National Library of Medicine, public domain)
- Publications: Europe PMC API search by NCT ID, retrieved 10 June 2026
- Drug + disease cross-links: matched in real time against Drug Landscape's normalised drug + company + condition tables
- Sponsor: as reported to ClinicalTrials.gov by University Medical Center Groningen
- Last refreshed: 18 December 2025
Drug Landscape aggregates and links these public records for informational use only. Always verify against the primary source before clinical or regulatory decisions. Canonical URL: https://druglandscape.com/trial/NCT05782543.
Primary sources · FDA · ClinicalTrials.gov · EMA · SEC EDGAR · ChEMBL · Wikidata · full sourcing