NCT05755321 is a clinical trial of Skin biopsy in Diabetes Mellitus, Type 2, sponsored by Fondazione Policlinico Universitario Agostino Gemelli IRCCS.

Who is sponsoring NCT05755321?

NCT05755321 is sponsored by Fondazione Policlinico Universitario Agostino Gemelli IRCCS.

What drugs are being tested in NCT05755321?

Interventions in NCT05755321: Skin biopsy.

What condition does NCT05755321 study?

NCT05755321 studies Diabetes Mellitus, Type 2, Diabetes Mellitus Type 2 in Obese, Diabetes Mellitus Type 2 in Nonobese, Obesity, Cognitive Dysfunction, Metabolism Disorder.

Is NCT05755321 still recruiting?

NCT05755321 is currently status unknown. Last updated 10 March 2023.

Last reviewed 2023-03-10 · How we verify

NCT05755321

Name: Drug Landscape Pharmaceutical Database
Creator: Drug Landscape
Published: 2026-01-01
License: https://creativecommons.org/licenses/by/4.0/

From Skin Fibroblasts to Neural Stem Cells to Investigate in Vitro the Impact of Diabetes on Adult Neurogenesis

Status unknown Last updated 10 March 2023

What this trial tests

trial testing Skin biopsy in Diabetes Mellitus, Type 2 in 40 participants. Status unknown.

Timeline

1 January 2020

Primary endpoint
30 April 2023

14 May 2023

Quick facts

Lead sponsor	Fondazione Policlinico Universitario Agostino Gemelli IRCCS
Status	Status unknown
Study type	OBSERVATIONAL
Enrollment	40
Start date	1 January 2020
Primary completion	30 April 2023
Estimated completion	14 May 2023
Sites	1 location across Italy

Drugs / interventions tested

Skin biopsy

Conditions studied

Diabetes Mellitus, Type 2 — all drugs for Diabetes Mellitus, Type 2 →
Diabetes Mellitus Type 2 in Obese — all drugs for Diabetes Mellitus Type 2 in Obese →
Diabetes Mellitus Type 2 in Nonobese — all drugs for Diabetes Mellitus Type 2 in Nonobese →
Obesity — all drugs for Obesity →

Sponsor

Fondazione Policlinico Universitario Agostino Gemelli IRCCS

Who can join

Eligibility, any sex, with Diabetes Mellitus, Type 2 or Diabetes Mellitus Type 2 in Obese. Patients with the condition only — healthy volunteers not accepted.

Sponsor's own description

Obesity and glucose intolerance or overt diabetes are increasing at an alarming rate in the population, and are bound to become a public health issue and a major cause of disability, loss of independence and high social costs in the near future. A large body of evidence has in recent years highlighted, among the negative effects of overnutrition and glucose dysmetabolism, also an acceleration of cognitive decline and of brain senescence, through cellular (vascular, neuronal, or both) and molecular mechanisms still incompletely clarified. Understanding how overweight and impaired glucose homeostasis negatively affect brain function represents both a major scientific challenge and an avenue to early detection and possibly prevention of this invalidating complication. The aim of this project is to obtain neuronal progenitor-like cells from skin fibroblasts in order to correlate patient-specific metabolism to adult neural stem cell (NSC) and neuronal function in vitro.

Publications & conference data

3 peer-reviewed publications reference this trial (live from Europe PMC):

Emerging Pro-neurogenic Therapeutic Strategies for Neurodegenerative Diseases: A Review of Pre-clinical and Clinical Research.
Vassal M, Martins F, Monteiro B, Tambaro S, et al · · 2025 · cited 12× · PMID 38816676 · DOI 10.1007/s12035-024-04246-w
Current understanding and prospects for targeting neurogenesis in the treatment of cognitive impairment.
Liu Y, Ding X, Jia S, Gu X. · · 2026 · cited 10× · PMID 39820472 · DOI 10.4103/nrr.nrr-d-24-00802
Sustaining Brain Youth by Neural Stem Cells: Physiological and Therapeutic Perspectives.
Santos M, Moreira JAF, Santos SS, Solá S. · · 2025 · cited 2× · PMID 39985708 · DOI 10.1007/s12035-025-04774-z

Verify or expand the search:

Other trials of Skin biopsy

Trials testing the same drug.

NCT07236736 — Evaluation of SPM™ Topical Cosmetic Application on Skin Appearance, Hydration, and Barrier Support in Healthy Adults · NA · not yet recruiting
NCT07049588 — Identification of Novel Biomarkers in Early Charcot-Marie-Tooth 1A Disease · NA · recruiting
NCT06539351 — A Pilot Study to Finetune Skin Processing Procedures in Recent Vaccinees, Prior to GeKoSkimm Study Initiation (GeKoSkimm · NA · completed
NCT06467461 — Identification of Prodromal Neurodegeneration in Serotonergic-Induced REM Sleep Behavior Disorder · NA · recruiting
NCT04872452 — Analysis of Cutaneous Nerve Biopsies in Gastrointestinal Motility Disorders · NA · withdrawn

Other recruiting trials for Diabetes Mellitus, Type 2

Currently open trials in the same condition.

NCT07415954 — A Research Study Comparing How Well Different Doses of the Medicine NNC0662-0419 Lower Blood Sugar in People With Type 2 · Phase 2 · recruiting
NCT07532863 — A Real-world Study to Investigate Cardiovascular Risk Profile Among Newly Diagnosed Type 2 Diabetes Mellitus (T2DM) Part · recruiting
NCT07336329 — Continuous Glucose Monitoring in Non-Insulin Treated Type 2 Diabetes: Continuous vs. Periodic Use · NA · recruiting
NCT07242469 — A Clinical Trial of MK-1403 in Participants With Type 2 Diabetes Mellitus (MK-1403-006) · Phase 1 · recruiting
NCT07444203 — Transformative Research in Diabetic Nephropathy 2.0 · recruiting

Other Fondazione Policlinico Universitario Agostino Gemelli IRCCS trials

Trials by the same sponsor.

NCT07514572 — Impact of Estimated Weight and Height on Nutritional Assessment in Elderly · NA · not yet recruiting
NCT07504679 — Adipose Visceral and Epicardial Risk Evaluation · NA · not yet recruiting
NCT07520643 — MISTIC Study: Atherosclerosis, Neurocognition & Cardiovascular Signaling · not yet recruiting
NCT07479238 — Breath Test-Based Assessment of SIBO in Chronic Pancreatitis and Partial Pancreatectomy · not yet recruiting
NCT07494227 — Development of the SC-IBD Self-Care Measurement Scale · not yet recruiting

Verify against primary sources

ClinicalTrials.gov — authoritative US registry record
WHO ICTRP — international registry index
EU Clinical Trials Register
Sponsor press releases (Google)

Data sources for this page

Trial protocol + status: ClinicalTrials.gov NCT05755321 (US National Library of Medicine, public domain)
Publications: Europe PMC API search by NCT ID, retrieved 10 June 2026
Drug + disease cross-links: matched in real time against Drug Landscape's normalised drug + company + condition tables
Sponsor: as reported to ClinicalTrials.gov by Fondazione Policlinico Universitario Agostino Gemelli IRCCS
Last refreshed: 10 March 2023

Drug Landscape aggregates and links these public records for informational use only. Always verify against the primary source before clinical or regulatory decisions. Canonical URL: https://druglandscape.com/trial/NCT05755321.

Primary sources · FDA · ClinicalTrials.gov · EMA · SEC EDGAR · ChEMBL · Wikidata · full sourcing