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NCT05754255
Comparison of High-flow Oxygen With or Without Nasal Positive Airway Pressure (PAP) During Propofol Sedation for Colonoscopy in an Ambulatory Surgical Center: a Prospective Randomized Controlled Trial
NA trial testing Nasal Cannula in Colonoscopy. Withdrawn.
1 June 2024
Quick facts
| Lead sponsor | Indiana University |
|---|---|
| Phase | NA |
| Status | Withdrawn |
| Study type | INTERVENTIONAL |
| Allocation | randomized |
| Design | parallel |
| Masking | none |
| Primary purpose | supportive care |
| Start date | 1 September 2023 |
| Primary completion | 1 June 2024 |
| Estimated completion | 3 June 2024 |
| Sites | 1 location across United States |
Drugs / interventions tested
- Nasal Cannula
- Nasal Positive Airway Pressure System
Conditions studied
- Colonoscopy — all drugs for Colonoscopy →
- Positive-Pressure Respiration — all drugs for Positive-Pressure Respiration →
Sponsor
Indiana University
Who can join
18 and older, any sex, with Colonoscopy or Positive-Pressure Respiration. Patients with the condition only — healthy volunteers not accepted.
What's being measured
Primary outcomes are the specific endpoints the trial is designed to prove or disprove.
-
Incidence of desaturation
Time frame: 60 minutes
Compare incidence of desaturation of Nasal PAP Versus Nasal Administration of Oxygen -
Duration of oxygen desaturation
Time frame: 60 minutes
Compare the duration of desaturation of Nasal PAP Versus Nasal Administration of Oxygen -
Severity of oxygen desaturation
Time frame: 60 minutes
Compare the severity of desaturation of Nasal PAP Versus Nasal Administration of Oxygen
Sponsor's own description
The primary objective of the prospective study is to compare the incidence, duration, and severity of oxygen desaturation in high-risk patients randomized to nasal mask with nasal positive airway pressure (PAP) or standard care (nasal cannula) receiving propofol sedation during colonoscopy in an ambulatory surgical center (ASC). Patients will be randomized in groups of ten to one of two groups using a random number table. Group A: standard care with a nasal cannula. Group B: SuperNO2VA™EtCO2. Following the procedure subjects will be asked to complete satisfaction surveys before leaving the ASC and 48 +/- hours following their procedure. Researchers will compare levels of satisfaction and levels of oxygen saturation.
Publications & conference data
No peer-reviewed publications indexed yet for this trial.
Verify or expand the search:
- PubMed search for NCT05754255
- Europe PMC full search
- ASCO Meeting Library
- ESMO Meeting Library
- bioRxiv preprints
- medRxiv preprints
- Google Scholar
Related trials
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Trials testing the same drug.
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- NCT04792099 — CPAP Or Nasal Cannula Oxygen for Preterm Infants: A Randomized Controlled Trial · NA · completed
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Verify against primary sources
- ClinicalTrials.gov — authoritative US registry record
- WHO ICTRP — international registry index
- EU Clinical Trials Register
- Sponsor press releases (Google)
- Trial protocol + status: ClinicalTrials.gov NCT05754255 (US National Library of Medicine, public domain)
- Drug + disease cross-links: matched in real time against Drug Landscape's normalised drug + company + condition tables
- Sponsor: as reported to ClinicalTrials.gov by Indiana University
- Last refreshed: 22 February 2026
Drug Landscape aggregates and links these public records for informational use only. Always verify against the primary source before clinical or regulatory decisions. Canonical URL: https://druglandscape.com/trial/NCT05754255.
Primary sources · FDA · ClinicalTrials.gov · EMA · SEC EDGAR · ChEMBL · Wikidata · full sourcing