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NCT05751278: FROSTBITE-2
Cryoprobe Versus Forceps for Transbronchial Biopsy
NA trial testing ERBECRYO® 2 Cryosurgical Unit and Accessories - K190651 in Lung Diseases in 500 participants. Completed in 2 March 2026.
2 March 2026
Quick facts
| Lead sponsor | Johns Hopkins University |
|---|---|
| Phase | NA |
| Status | Completed |
| Study type | INTERVENTIONAL |
| Allocation | randomized |
| Design | parallel |
| Masking | double |
| Primary purpose | diagnostic |
| Enrollment | 500 |
| Start date | 27 February 2023 |
| Primary completion | 2 March 2026 |
| Estimated completion | 2 March 2026 |
| Sites | 9 locations across United States |
Drugs / interventions tested
- ERBECRYO® 2 Cryosurgical Unit and Accessories - K190651
- Radial Jaw 4 Pulmonary Biopsy Forceps
Conditions studied
- Lung Diseases — all drugs for Lung Diseases →
Sponsor
Johns Hopkins University
Who can join
18 and older, any sex, with Lung Diseases. Patients with the condition only — healthy volunteers not accepted.
Sponsor's own description
The purpose of this study is to compare the effectiveness of transbronchial biopsy done by a 1.1mm cryoprobe versus the standard 2.0mm forceps.
Publications & conference data
1 peer-reviewed publication reference this trial (live from Europe PMC):
-
Cryobiopsy vs Forceps for Bronchoscopic Lung Biopsy: The FROSTBITE-2 Randomized Clinical Trial.
Thiboutot J, Kapp CM, Illei P, Shofer S, et al · · 2026 · PMID 42149700 · DOI 10.1001/jama.2026.7908
Verify or expand the search:
- PubMed search for NCT05751278
- Europe PMC full search
- ASCO Meeting Library
- ESMO Meeting Library
- bioRxiv preprints
- medRxiv preprints
- Google Scholar
Related trials
Other trials of ERBECRYO® 2 Cryosurgical Unit and Accessories - K190651
Trials testing the same drug.
- NCT04486560 — Safety of a Sheath Cryoprobe Bronchoscopic Transbronchial Biopsy Technique · NA · completed
Other recruiting trials for Lung Diseases
Currently open trials in the same condition.
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Other Johns Hopkins University trials
Trials by the same sponsor.
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- NCT07532252 — Daridorexant for Alcohol Use Disorder · Phase 2 · not yet recruiting
- NCT06687655 — Impact of Exogenous Ketones on Sleep Apnea · Phase 1, PHASE2 · not yet recruiting
- NCT07079111 — 3D Printed Occlusal Splints for Intraoperative Use · NA · not yet recruiting
- NCT02998502 — The Use of a FDA Cleared, Drug-free, Breathing System for Anxiety and Panic Disorders in Children and Teens · NA · not yet recruiting
Verify against primary sources
- ClinicalTrials.gov — authoritative US registry record
- WHO ICTRP — international registry index
- EU Clinical Trials Register
- Sponsor press releases (Google)
- Trial protocol + status: ClinicalTrials.gov NCT05751278 (US National Library of Medicine, public domain)
- Publications: Europe PMC API search by NCT ID, retrieved 10 June 2026
- Drug + disease cross-links: matched in real time against Drug Landscape's normalised drug + company + condition tables
- Sponsor: as reported to ClinicalTrials.gov by Johns Hopkins University
- Last refreshed: 3 April 2026
Drug Landscape aggregates and links these public records for informational use only. Always verify against the primary source before clinical or regulatory decisions. Canonical URL: https://druglandscape.com/trial/NCT05751278.
Primary sources · FDA · ClinicalTrials.gov · EMA · SEC EDGAR · ChEMBL · Wikidata · full sourcing