NCT05745441 (DTOP) is a NA clinical trial of Early Dinner in PreDiabetes, sponsored by Johns Hopkins University.

Who is sponsoring NCT05745441?

NCT05745441 is sponsored by Johns Hopkins University.

What drugs are being tested in NCT05745441?

Interventions in NCT05745441: Early Dinner, Late Dinner, Early Dinner tracer, Late Dinner tracer.

What condition does NCT05745441 study?

NCT05745441 studies PreDiabetes, Obesity, Healthy.

Is NCT05745441 still recruiting?

NCT05745441 is currently recruiting now. Last updated 13 April 2026.

Last reviewed 2026-04-13 · How we verify

NCT05745441: DTOP

Name: Drug Landscape Pharmaceutical Database
Creator: Drug Landscape
Published: 2026-01-01
License: https://creativecommons.org/licenses/by/4.0/

Dinner Time for Obesity and Prediabetes

Recruiting now NA Last updated 13 April 2026

What this trial tests

NA trial testing Early Dinner in PreDiabetes in 32 participants. Currently enrolling.

Timeline

5 July 2023

Primary endpoint
31 March 2028

31 March 2028

Quick facts

Lead sponsor	Johns Hopkins University
Phase	NA
Status	Recruiting now
Study type	INTERVENTIONAL
Allocation	randomized
Design	crossover
Masking	none
Primary purpose	basic science
Enrollment	32
Start date	5 July 2023
Primary completion	31 March 2028
Estimated completion	31 March 2028
Sites	2 locations across United States

Drugs / interventions tested

Early Dinner
Late Dinner
Early Dinner tracer — full drug profile →
Late Dinner tracer — full drug profile →

Conditions studied

PreDiabetes — all drugs for PreDiabetes →
Obesity — all drugs for Obesity →
Healthy — all drugs for Healthy →

Sponsor

Johns Hopkins University

Who can join

Adults 18 to 50, any sex, with PreDiabetes or Obesity. Patients with the condition only — healthy volunteers not accepted.

Sponsor's own description

Obesity and its metabolic complications are leading causes of global morbidity and mortality. Evidence is mounting that inappropriate timing of food intake contributes to obesity. Specifically, late eating is associated with greater weight gain and metabolic syndrome. However, the mechanism by which late eating harms metabolism is not fully understood but may be related to mis-timing of food intake in relation to the body's endogenous circadian rhythm. Conversely, harmonization of eating timing with endogenous circadian rhythm may optimize metabolic health. In this study the investigators will use gold-standard methods of characterizing circadian rhythm in humans to examine the metabolic impacts food timing relative to endogenous circadian rhythm.

Publications & conference data

No peer-reviewed publications indexed yet for this trial.

Verify or expand the search:

Other recruiting trials for PreDiabetes

Currently open trials in the same condition.

NCT06897982 — Feasibility of a Nutrition Intervention for Patients With Prediabetes at a Federally Qualified Health Center · NA · recruiting
NCT06967558 — The Role of Islet GLP-1 in the Pathogenesis of Prediabetes · Phase 2 · recruiting
NCT06482944 — Whole Food for Families: A Pilot RCT of a Dietary Guidelines-Based Intervention to Prevent Type 2 Diabetes · NA · recruiting
NCT06989164 — Post Prandial Individual Responses to Different Foods · NA · recruiting
NCT07254572 — Anti-atherosclerotic Efficacy of Selected Antidiabetic Drugs in Patients With Coronary Artery Disease and Pre-diabetes · Phase 4 · recruiting

Other Johns Hopkins University trials

Trials by the same sponsor.

NCT06236542 — Tracheostomy Robotics and Cutting-edge Health Education for Airway Safety · NA · not yet recruiting
NCT07532252 — Daridorexant for Alcohol Use Disorder · Phase 2 · not yet recruiting
NCT06687655 — Impact of Exogenous Ketones on Sleep Apnea · Phase 1, PHASE2 · not yet recruiting
NCT07079111 — 3D Printed Occlusal Splints for Intraoperative Use · NA · not yet recruiting
NCT02998502 — The Use of a FDA Cleared, Drug-free, Breathing System for Anxiety and Panic Disorders in Children and Teens · NA · not yet recruiting

Verify against primary sources

ClinicalTrials.gov — authoritative US registry record
WHO ICTRP — international registry index
EU Clinical Trials Register
Sponsor press releases (Google)

Data sources for this page

Trial protocol + status: ClinicalTrials.gov NCT05745441 (US National Library of Medicine, public domain)
Drug + disease cross-links: matched in real time against Drug Landscape's normalised drug + company + condition tables
Sponsor: as reported to ClinicalTrials.gov by Johns Hopkins University
Last refreshed: 13 April 2026

Drug Landscape aggregates and links these public records for informational use only. Always verify against the primary source before clinical or regulatory decisions. Canonical URL: https://druglandscape.com/trial/NCT05745441.

Primary sources · FDA · ClinicalTrials.gov · EMA · SEC EDGAR · ChEMBL · Wikidata · full sourcing