NCT05742321 (F3S2) is a clinical trial of Genotyping in Corneal Dystrophies, sponsored by Centre Hospitalier Universitaire de Saint Etienne.

Who is sponsoring NCT05742321?

NCT05742321 is sponsored by Centre Hospitalier Universitaire de Saint Etienne.

What drugs are being tested in NCT05742321?

Interventions in NCT05742321: Genotyping, Histology, Collection of data.

What condition does NCT05742321 study?

NCT05742321 studies Corneal Dystrophies.

Is NCT05742321 still recruiting?

NCT05742321 is currently recruiting now. Last updated 9 August 2024.

Last reviewed 2024-08-09 · How we verify

NCT05742321: F3S2

Name: Drug Landscape Pharmaceutical Database
Creator: Drug Landscape
Published: 2026-01-01
License: https://creativecommons.org/licenses/by/4.0/

Analysis of the Genotype/Phenotype Relationship in the Fuchs' Corneal Endothelial Dystrophy in France

Recruiting now Last updated 9 August 2024

What this trial tests

trial testing Genotyping in Corneal Dystrophies in 500 participants. Currently enrolling.

Timeline

8 August 2024

Primary endpoint
1 March 2026

1 June 2026

Quick facts

Lead sponsor	Centre Hospitalier Universitaire de Saint Etienne
Status	Recruiting now
Study type	OBSERVATIONAL
Enrollment	500
Start date	8 August 2024
Primary completion	1 March 2026
Estimated completion	1 June 2026
Sites	1 location across France

Drugs / interventions tested

Genotyping
Histology — full drug profile →
Collection of data

Conditions studied

Corneal Dystrophies — all drugs for Corneal Dystrophies →

Sponsor

Centre Hospitalier Universitaire de Saint Etienne

Who can join

18 and older, any sex, with Corneal Dystrophies. Patients with the condition only — healthy volunteers not accepted.

Sponsor's own description

The pathophysiology of the most common corneal endothelial dystrophies (Fuchs' Corneal Endothelial Dystrophy, FECD) is beginning to be dismembered. There is a significant heterogeneity in the clinical forms and the investigators have just highlighted a great diversity of histological forms that seem to define distinct groups.

Publications & conference data

2 peer-reviewed publications reference this trial (live from Europe PMC):

Pathological classification of Fuchs endothelial corneal dystrophy into several types and their relationships with CTG18.1 expansion repeats.
Vaitinadapoulé H, Onitiu D, Maurin C, Travers G, et al · · 2026 · cited 2× · PMID 41736702 · DOI 10.1002/path.70044
Tissue-level heterogeneity in FECD: Descemet's membrane phenotypes and association with TCF4 CTG18.1 expansion<sup>†</sup>.
Maeno S, Oie Y, Kai C, Nishida K. · · 2026 · PMID 41944554 · DOI 10.1002/path.70057

Verify or expand the search:

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Other Centre Hospitalier Universitaire de Saint Etienne trials

Trials by the same sponsor.

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Verify against primary sources

ClinicalTrials.gov — authoritative US registry record
WHO ICTRP — international registry index
EU Clinical Trials Register
Sponsor press releases (Google)

Data sources for this page

Trial protocol + status: ClinicalTrials.gov NCT05742321 (US National Library of Medicine, public domain)
Publications: Europe PMC API search by NCT ID, retrieved 10 June 2026
Drug + disease cross-links: matched in real time against Drug Landscape's normalised drug + company + condition tables
Sponsor: as reported to ClinicalTrials.gov by Centre Hospitalier Universitaire de Saint Etienne
Last refreshed: 9 August 2024

Drug Landscape aggregates and links these public records for informational use only. Always verify against the primary source before clinical or regulatory decisions. Canonical URL: https://druglandscape.com/trial/NCT05742321.

Primary sources · FDA · ClinicalTrials.gov · EMA · SEC EDGAR · ChEMBL · Wikidata · full sourcing