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NCT05736380
The Effects of Cerebellar rTMS on Brain Activity
NA trial testing Cerebellar rTMS in The Effects of Cerebellar rTMS on the Brain in 8 participants. Suspended.
31 December 2025
Quick facts
| Lead sponsor | University of Manchester |
|---|---|
| Phase | NA |
| Status | Suspended |
| Study type | INTERVENTIONAL |
| Allocation | randomized |
| Design | crossover |
| Masking | single |
| Primary purpose | basic science |
| Enrollment | 8 |
| Start date | 1 June 2025 |
| Primary completion | 31 December 2025 |
| Estimated completion | 28 February 2026 |
| Sites | 1 location across United Kingdom |
Drugs / interventions tested
- Cerebellar rTMS
- Sham cerebellar rTMS
Conditions studied
- The Effects of Cerebellar rTMS on the Brain — all drugs for The Effects of Cerebellar rTMS on the Brain →
Sponsor
University of Manchester
Who can join
18 and older, any sex, with The Effects of Cerebellar rTMS on the Brain. Patients with the condition only — healthy volunteers not accepted.
Sponsor's own description
Swallowing function is controlled by two swallowing centres (one on each half of the brain). There is a dominant and non-dominant swallowing centre. Damage to any part of the brain can lead to swallowing problems, for example in strokes. Recovery of the ability to swallow is associated with increased activity (compensation) over the undamaged centre. The cerebellum is an area of the brain involved in the control and modulation of muscle movements. It is found at the back of the skull. Anatomical evidence exists, showing cerebellar outputs projecting to several cortical areas, including the primary motor cortex (M1). Moreover, brain imaging studies have shown activation of the cerebellum during swallowing using positron emission tomography (PET) and magnetic resonance imaging (MRI). Over the past few years studies have tried to improve swallowing function using techniques to stimulate regions of the brain and encourage compensation. Repetitive transcranial magnetic stimulation (rTMS) is a technique which can temporarily increase or suppress activity over regions of the brain. No imaging studies have been conducted which have looked at how the brain is affected by cerebellar rTMS. The investigators hypothesise that cerebellar rTMS will cause increased activity in swallowing associated areas in the brain, including the cortex and brainstem
Publications & conference data
No peer-reviewed publications indexed yet for this trial.
Verify or expand the search:
- PubMed search for NCT05736380
- Europe PMC full search
- ASCO Meeting Library
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Related trials
Other trials of Cerebellar rTMS
Trials testing the same drug.
- NCT06721533 — Cerebellar Metaplasticity in the Swallowing Motor System · NA · not yet recruiting
Other University of Manchester trials
Trials by the same sponsor.
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Verify against primary sources
- ClinicalTrials.gov — authoritative US registry record
- WHO ICTRP — international registry index
- EU Clinical Trials Register
- Sponsor press releases (Google)
- Trial protocol + status: ClinicalTrials.gov NCT05736380 (US National Library of Medicine, public domain)
- Drug + disease cross-links: matched in real time against Drug Landscape's normalised drug + company + condition tables
- Sponsor: as reported to ClinicalTrials.gov by University of Manchester
- Last refreshed: 1 April 2025
Drug Landscape aggregates and links these public records for informational use only. Always verify against the primary source before clinical or regulatory decisions. Canonical URL: https://druglandscape.com/trial/NCT05736380.
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