Last reviewed · How we verify
NCT05718245
HEPA, PM2.5, and Cardiometabolic Health
NA trial testing HEPA filter in Air Pollution in 52 participants. Currently enrolling.
31 December 2026
Quick facts
| Lead sponsor | University of Southern California |
|---|---|
| Phase | NA |
| Status | Recruiting now |
| Study type | INTERVENTIONAL |
| Allocation | randomized |
| Design | crossover |
| Masking | double |
| Primary purpose | prevention |
| Enrollment | 52 |
| Start date | 15 March 2023 |
| Primary completion | 31 December 2026 |
| Estimated completion | 31 December 2026 |
| Sites | 1 location across United States |
Drugs / interventions tested
- HEPA filter
- Sham filter
Conditions studied
- Air Pollution — all drugs for Air Pollution →
- Cardiometabolic Health — all drugs for Cardiometabolic Health →
Sponsor
University of Southern California
Who can join
Adults 65 to 84, any sex, with Air Pollution or Cardiometabolic Health. Patients with the condition only — healthy volunteers not accepted.
Sponsor's own description
The goal of this randomized, double-blind, crossover trial is to test the hypothesis that a longer-term indoor HEPA filtration intervention can improve cardiometabolic profiles by reducing indoor PM2.5 exposures in at-risk individuals.
Publications & conference data
1 peer-reviewed publication reference this trial (live from Europe PMC):
-
Fine particulate matter levels and HEPA filtration in Los Angeles homes during a wildland-urban-interface fire.
Chen R, Lin Y, Liao J, Qiu C, et al · · 2026 · PMID 41550628 · DOI 10.1038/s44407-025-00042-5
Verify or expand the search:
- PubMed search for NCT05718245
- Europe PMC full search
- ASCO Meeting Library
- ESMO Meeting Library
- bioRxiv preprints
- medRxiv preprints
- Google Scholar
Related trials
Other trials of HEPA filter
Trials testing the same drug.
- NCT02258893 — Indoor Air Pollution and Children With Asthma: An Intervention Trial · NA · completed
Other recruiting trials for Air Pollution
Currently open trials in the same condition.
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- NCT05867381 — Using Indoor Air Filtration to Slow Atherothrombosis Progression in Adults With Ischemic Heart Disease History · NA · recruiting
Other University of Southern California trials
Trials by the same sponsor.
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- NCT05914233 — Non-invasive Ultrasound Retinal Stimulation for Vision Restoration · NA · not yet recruiting
- NCT06163664 — Role of ChatGPT in Vestibular Schwannoma Management · NA · withdrawn
- NCT07332312 — A Culturally Informed Patient Navigation Program (CFPN) to Reduce Delays Between Diagnosis and Treatment in American Ind · NA · not yet recruiting
- NCT07290478 — Encouraging Older Adults and Adults With Serious Illness to Designate a Health Care Proxy · NA · not yet recruiting
Verify against primary sources
- ClinicalTrials.gov — authoritative US registry record
- WHO ICTRP — international registry index
- EU Clinical Trials Register
- Sponsor press releases (Google)
- Trial protocol + status: ClinicalTrials.gov NCT05718245 (US National Library of Medicine, public domain)
- Publications: Europe PMC API search by NCT ID, retrieved 10 June 2026
- Drug + disease cross-links: matched in real time against Drug Landscape's normalised drug + company + condition tables
- Sponsor: as reported to ClinicalTrials.gov by University of Southern California
- Last refreshed: 1 August 2025
Drug Landscape aggregates and links these public records for informational use only. Always verify against the primary source before clinical or regulatory decisions. Canonical URL: https://druglandscape.com/trial/NCT05718245.
Primary sources · FDA · ClinicalTrials.gov · EMA · SEC EDGAR · ChEMBL · Wikidata · full sourcing