NCT05701943 (UPSIDE DOWNS) is a NA clinical trial of Home-Based in Vascular Stiffness, sponsored by Egas Moniz - Cooperativa de Ensino Superior, CRL.

Who is sponsoring NCT05701943?

NCT05701943 is sponsored by Egas Moniz - Cooperativa de Ensino Superior, CRL.

What drugs are being tested in NCT05701943?

Interventions in NCT05701943: Home-Based, Gym-Based.

What condition does NCT05701943 study?

NCT05701943 studies Vascular Stiffness, Cardiorespiratory Fitness.

Is NCT05701943 still recruiting?

NCT05701943 is currently completed. Last updated 27 January 2023.

Last reviewed 2023-01-27 · How we verify

NCT05701943: UPSIDE DOWNS

Name: Drug Landscape Pharmaceutical Database
Creator: Drug Landscape
Published: 2026-01-01
License: https://creativecommons.org/licenses/by/4.0/

Comparison of Home- vs. Gym-based Exercise Delivery Modes

Completed NA Last updated 27 January 2023

What this trial tests

NA trial testing Home-Based in Vascular Stiffness in 17 participants. Completed in 30 July 2021.

Timeline

2 November 2020

Primary endpoint
30 July 2021

30 July 2021

Quick facts

Lead sponsor	Egas Moniz - Cooperativa de Ensino Superior, CRL
Phase	NA
Status	Completed
Study type	INTERVENTIONAL
Allocation	randomized
Design	parallel
Masking	single
Primary purpose	prevention
Enrollment	17
Start date	2 November 2020
Primary completion	30 July 2021
Estimated completion	30 July 2021
Sites	1 location across Portugal

Drugs / interventions tested

Home-Based
Gym-Based

Conditions studied

Vascular Stiffness — all drugs for Vascular Stiffness →
Cardiorespiratory Fitness — all drugs for Cardiorespiratory Fitness →

Sponsor

Egas Moniz - Cooperativa de Ensino Superior, CRL — full company profile →

Who can join

Adults 18 to 55, any sex, with Vascular Stiffness or Cardiorespiratory Fitness. Patients with the condition only — healthy volunteers not accepted.

Sponsor's own description

Home-based exercise interventions were the only alternatives to attenuate physical deconditioning and ameliorate traditional and emergent cardiovascular risk factors progression during the COVID-19 outbreak. Benefits in physical and psychological health have only been reported in adults without intellectual and developmental disability (IDD). The purpose of this study is to compare home vs gym-based delivery exercise modes of two 8-week supervised aerobic training regimes on cardiorespiratory fitness and arterial structure and stiffness in adults with IDD. It is hypothesized that home- and gym- based exercise delivery modes will be equally effective in improving cardiorespiratory fitness and overall arterial heath, although in an intensity dependent manner. A secondary analysis examining changes in blood pressure and body composition will be performed.

Publications & conference data

1 peer-reviewed publication reference this trial (live from Europe PMC):

Home- vs gym-based exercise delivery modes of two multicomponent intensity training regimes on cardiorespiratory fitness and arterial stiffness in adults with intellectual and developmental disability during the COVID-19 pandemic - a randomized controlled trial.
Melo X, Simão B, Catela C, Oliveira I, et al · · 2025 · cited 2× · PMID 38537027 · DOI 10.1177/17446295241242507

Verify or expand the search:

Other recruiting trials for Vascular Stiffness

Currently open trials in the same condition.

NCT06419959 — NightWare and Cardiovascular Health in Veterans With PTSD · NA · recruiting
NCT06495710 — Arterial Stiffness and Blood Pressure · NA · recruiting
NCT03672760 — Inspiratory Muscle Training X CardioBreath App Effects On Vagal Modulation And Pulse Wave Velocity · NA · recruiting
NCT05823025 — Withings Study to Analyze the Accuracy of Pulse Wave Velocity Measurement With Bathroom Scales (WIVOP-Scales) · active not recruiting
NCT05388032 — Sodium Lowering Vascular Effects Trial · NA · recruiting

Other Egas Moniz - Cooperativa de Ensino Superior, CRL trials

Trials by the same sponsor.

NCT07533110 — Evaluation Of The Success Rate of NOVAMag® SHIELD In Two Different Advanced Bone Defects: A Randomized Controlled Trial · Phase 4 · recruiting
NCT07411833 — tDCS for Stress and Burnout in Higher Education · NA · enrolling by invitation
NCT07190456 — Kinesiophobia vs. Task-Specific Fear: Defining Movement-Related Fear in ACL Reconstruction Patients · NA · recruiting
NCT07352384 — Evaluation of the Efficacy of Neuromodulation in the Control of Chronic Orofacial Pain · NA · enrolling by invitation
NCT07079280 — Comparing Vascular Responses to Aerobic Exercise With and Without Blood Flow Restriction in Young and Older Adults · NA · not yet recruiting

Verify against primary sources

ClinicalTrials.gov — authoritative US registry record
WHO ICTRP — international registry index
EU Clinical Trials Register
Sponsor press releases (Google)

Data sources for this page

Trial protocol + status: ClinicalTrials.gov NCT05701943 (US National Library of Medicine, public domain)
Publications: Europe PMC API search by NCT ID, retrieved 10 June 2026
Drug + disease cross-links: matched in real time against Drug Landscape's normalised drug + company + condition tables
Sponsor: as reported to ClinicalTrials.gov by Egas Moniz - Cooperativa de Ensino Superior, CRL
Last refreshed: 27 January 2023

Drug Landscape aggregates and links these public records for informational use only. Always verify against the primary source before clinical or regulatory decisions. Canonical URL: https://druglandscape.com/trial/NCT05701943.

Primary sources · FDA · ClinicalTrials.gov · EMA · SEC EDGAR · ChEMBL · Wikidata · full sourcing