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NCT07352384: NeuroFace
Evaluation of the Efficacy of Neuromodulation in the Control of Chronic Orofacial Pain
NA trial testing Active Neuromodulation (tDCS or TMS) in Orofacial Pain in 50 participants. Enrolling by invitation.
1 May 2026
Quick facts
| Lead sponsor | Egas Moniz - Cooperativa de Ensino Superior, CRL |
|---|---|
| Phase | NA |
| Status | ENROLLING BY INVITATION |
| Study type | INTERVENTIONAL |
| Allocation | randomized |
| Design | parallel |
| Masking | triple |
| Primary purpose | treatment |
| Enrollment | 50 |
| Start date | 1 November 2025 |
| Primary completion | 1 May 2026 |
| Estimated completion | 1 August 2026 |
| Sites | 1 location across Portugal |
Drugs / interventions tested
- Active Neuromodulation (tDCS or TMS)
- Sham Neuromodulation (tDCS or TMS)
Conditions studied
- Orofacial Pain — all drugs for Orofacial Pain →
Sponsor
Egas Moniz - Cooperativa de Ensino Superior, CRL — full company profile →
Who can join
Adults 18 to 75, any sex, with Orofacial Pain. Patients with the condition only — healthy volunteers not accepted.
Sponsor's own description
Chronic orofacial pain significantly affects patients' quality of life, compromising essential functions such as chewing and speech. Although conventional treatments are available, many patients do not achieve adequate and lasting relief. This project investigates the effectiveness of neuromodulation techniques, namely transcranial direct current stimulation (tDCS) and transcranial magnetic stimulation (TMS), as innovative therapeutic alternatives for the control of chronic orofacial pain. The study will be conducted in adult patients diagnosed with orofacial pain. Participants will be divided into two groups: one group will receive active neuromodulation (tDCS or TMS) and the other a sham treatment (placebo). Sessions will take place daily over two weeks. Assessments will include pain intensity, pain pressure threshold, masticatory function, and bite strength, in order to observe any functional changes. The group undergoing neuromodulation is expected to show a significant reduction in pain levels and improvements in quality of life compared to the placebo group. This study could support the adoption of neuromodulation as a complementary approach in the treatment of chronic orofacial pain, offering an effective and non-invasive alternative for patients who do not respond to conventional treatments.
Publications & conference data
No peer-reviewed publications indexed yet for this trial.
Verify or expand the search:
- PubMed search for NCT07352384
- Europe PMC full search
- ASCO Meeting Library
- ESMO Meeting Library
- bioRxiv preprints
- medRxiv preprints
- Google Scholar
Related trials
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Other Egas Moniz - Cooperativa de Ensino Superior, CRL trials
Trials by the same sponsor.
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Verify against primary sources
- ClinicalTrials.gov — authoritative US registry record
- WHO ICTRP — international registry index
- EU Clinical Trials Register
- Sponsor press releases (Google)
- Trial protocol + status: ClinicalTrials.gov NCT07352384 (US National Library of Medicine, public domain)
- Drug + disease cross-links: matched in real time against Drug Landscape's normalised drug + company + condition tables
- Sponsor: as reported to ClinicalTrials.gov by Egas Moniz - Cooperativa de Ensino Superior, CRL
- Last refreshed: 20 February 2026
Drug Landscape aggregates and links these public records for informational use only. Always verify against the primary source before clinical or regulatory decisions. Canonical URL: https://druglandscape.com/trial/NCT07352384.
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