Last reviewed · How we verify
NCT05699707: KM
Metabolomic Signature of Exogenous Ketosis
NA trial testing (R)-3-hydroxybutyl (R)-3-hydroxybutyrate ketone monoester in Ketosis in 5 participants. Completed in 1 April 2023.
1 April 2023
Quick facts
| Lead sponsor | University of British Columbia |
|---|---|
| Phase | NA |
| Status | Completed |
| Study type | INTERVENTIONAL |
| Allocation | na |
| Design | single group |
| Masking | none |
| Primary purpose | basic science |
| Enrollment | 5 |
| Start date | 1 February 2023 |
| Primary completion | 1 April 2023 |
| Estimated completion | 1 April 2023 |
| Sites | 1 location across Canada |
Drugs / interventions tested
- (R)-3-hydroxybutyl (R)-3-hydroxybutyrate ketone monoester
Conditions studied
- Ketosis — all drugs for Ketosis →
Sponsor
University of British Columbia
Who can join
18 and older, any sex, with Ketosis. Patients with the condition only — healthy volunteers not accepted.
Sponsor's own description
Ketone bodies are a fuel source and signaling molecule that are produced by your body during prolonged fasting or if you consistently eat at low-carbohydrate diet. Blood ketones can be used as a source of energy during fasting and are used by your brain as an alternative source of fuel to glucose. Previous studies have found that ketones, when consumed in form of a supplement drink, can increase blood ketone levels and lower blood glucose, the amount of sugar in your blood. This is of potential interest for individuals with high blood sugar, such as people living with type 2 diabetes. However, how ketone supplements impact metabolism is not fully understood but using high throughput analysis techniques that can characterize hundreds to thousands of metabolites in the blood (known as "metabolomics") may allow researchers to discover novel compounds within the body that are altered by ketone supplements. This will improve our understanding of how ketones impact metabolism and guide future research.
Publications & conference data
No peer-reviewed publications indexed yet for this trial. Completed trials usually publish results within 12-18 months.
Verify or expand the search:
- PubMed search for NCT05699707
- Europe PMC full search
- ASCO Meeting Library
- ESMO Meeting Library
- bioRxiv preprints
- medRxiv preprints
- Google Scholar
Related trials
Other trials of (R)-3-hydroxybutyl (R)-3-hydroxybutyrate ketone monoester
Trials testing the same drug.
- NCT05273411 — The Effect of Different Ketone Supplements on β-OHB and Blood Glucose in Healthy Individuals · NA · completed
Other recruiting trials for Ketosis
Currently open trials in the same condition.
- NCT06815237 — Effects of Ketone Supplement and Alcohol on Brain Metabolism · Phase 2, PHASE3 · recruiting
- NCT06338969 — The Impact of Different Carbohydrate Restriction After a Gastric Bypass on the Ketosis and Ketoacidosis · NA · recruiting
- NCT05924295 — Variations in Ketone Metabolism · NA · recruiting
Other University of British Columbia trials
Trials by the same sponsor.
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- NCT07492095 — Leucine Requirements in School-Age Children · NA · not yet recruiting
- NCT07429305 — Combined Tibial Nerve Stimulation and Standing for People With SCI · NA · recruiting
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Verify against primary sources
- ClinicalTrials.gov — authoritative US registry record
- WHO ICTRP — international registry index
- EU Clinical Trials Register
- Sponsor press releases (Google)
- Trial protocol + status: ClinicalTrials.gov NCT05699707 (US National Library of Medicine, public domain)
- Drug + disease cross-links: matched in real time against Drug Landscape's normalised drug + company + condition tables
- Sponsor: as reported to ClinicalTrials.gov by University of British Columbia
- Last refreshed: 16 May 2023
Drug Landscape aggregates and links these public records for informational use only. Always verify against the primary source before clinical or regulatory decisions. Canonical URL: https://druglandscape.com/trial/NCT05699707.
Primary sources · FDA · ClinicalTrials.gov · EMA · SEC EDGAR · ChEMBL · Wikidata · full sourcing