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The Effect of Different Ketone Supplements on β-OHB and Blood Glucose in Healthy Individuals
NA trial testing (R)-3-hydroxybutyl (R)-3-hydroxybutyrate ketone monoester in Ketosis in 12 participants. Completed in 18 May 2022.
| Lead sponsor | University of British Columbia |
|---|---|
| Phase | NA |
| Status | Completed |
| Study type | INTERVENTIONAL |
| Allocation | randomized |
| Design | crossover |
| Masking | triple |
| Primary purpose | other |
| Enrollment | 12 |
| Start date | 24 March 2022 |
| Primary completion | 18 May 2022 |
| Estimated completion | 18 May 2022 |
| Sites | 1 location across Canada |
University of British Columbia
18 and older, any sex, with Ketosis or Blood Glucose. Patients with the condition only — healthy volunteers not accepted.
Per-arm endpoint measurements with 95% confidence intervals where reported. Source: trial results section.
Are under the curve (AUC) across 240 minutes after supplement consumption (assessed at baseline and 15, 30, 60, 90, 120, 180, and 240 post-supplementation)
| Group | Value | 95% CI |
|---|---|---|
| (R)-3-hydroxybutyl (R)-3-hydroxybutyrate Ketone Monoester | 217 | ± 51 |
| Beta-hydroxybutyric Acid | 192 | ± 63 |
| 1,3-Butanediol | 176 | ± 59 |
Ketone bodies are a fuel source and signaling molecule that are produced by your body during prolonged fasting or if you consistently eat at low-carbohydrate diet. Blood ketones can be used as a source of energy during fasting and are used by your brain as an alternative source of fuel to glucose. Previous studies have found that ketones, when consumed in form of a supplement drink, can increase blood ketone levels and lower blood glucose, the amount of sugar in your blood. This is of potential interest for individuals with high blood sugar, such as people living with type 2 diabetes. However, there are different types of ketone supplements that differ in how they are metabolized in the body. Little is known about how these supplements affect blood ketone and blood glucose levels. The main objective of this study is to determine the effect of three different ketone supplements on blood ketones and blood glucose. The results of this pilot study will be used to guide future research for larger and more extensive studies on ketone supplements.
1 peer-reviewed publication reference this trial (live from Europe PMC):
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