45 and older, any sex, with Knee Osteoarthritis. Patients with the condition only — healthy volunteers not accepted.
Results — posted to ClinicalTrials.gov
Per-arm endpoint measurements with 95% confidence intervals where reported. Source: trial results section.
Change From Baseline in Knee Pain Measured by Numeric Pain Rating ScalePrimary· Change from Baseline at 1 month
Knee pain scored from 0 - 10 (0 being no pain and 10 being the worst pain)
Group
Value
95% CI
Active Comparator Group
-0.2
-0.5 – 0.0
Mindset Intervention Group
-0.5
-0.8 – -0.1
Survey-only Group
-0.1
-0.4 – 0.2
Change From Baseline in Physical Activity Measured by Physical Activity Scale for the ElderlyPrimary· Change from Baseline at 1 month
The Physical Activity Scale for the Elderly (PASE) asks respondents about the frequency of light, moderate, and strenuous work and leisure activities and is a validated measure of self-reported physical activity for individuals with osteoarthritis. The scale is scored from 0 (no physical activity) to 793 (very high physical activity).
Group
Value
95% CI
Active Comparator Group
32.6
18.7 – 46.3
Mindset Intervention Group
38.9
24.3 – 53.6
Survey-only Group
10.3
2.0 – 22.6
Change From Baseline in Mindset About the Process of Health - Physical Activity (MPH-Physical Activity) ScalePrimary· Change from Baseline at Post-intervention (immediately following intervention completion)
The Process of Health Mindset -- Exercise measure is a one-factor scale developed and validated to assess mindset about the process of engaging in physical activity (e.g., physical activity is difficult/easy, unpleasant/pleasurable, boring/fun). The scale consists of 7 items scored from 1 to 4, with a higher score reflecting a more appeal-focused mindset about physical activity, and then averaged for a total score between 1 to 4.
Group
Value
95% CI
Active Comparator Group
0.3
0.2 – 0.3
Mindset Intervention Group
0.5
0.4 – 0.6
Survey-only Group
0.1
0.0 – 0.1
Change From Baseline in Osteoarthritis Mindset by the Illness Mindset InventoryPrimary· Change from Baseline at Post-intervention (immediately following intervention completion)
The Illness Mindset Inventory measures three mindsets about the nature and meaning of illness: that it is a catastrophe, manageable, or an opportunity. The scale consists of 20 items measured on a 6-point scale and scored from 1 to 6, with 10 of those questions capturing mindsets about osteoarthritis. The extent to which a participant endorses a particular mindset can be obtained by calculating the mean score for each mindset. A higher score indicates greater agreement with the mindset. The investigators adapted the scale to focus on mindsets about "knee osteoarthritis" as opposed to "chronic
Osteoarthritis is Catastrophic
Group
Value
95% CI
Active Comparator Group
-0.5
-0.6 – -0.3
Mindset Intervention Group
-1.1
-1.3 – -1.0
Survey-only Group
-0.2
-0.3 – -0.1
Osteoarthritis is Manageable
Group
Value
95% CI
Active Comparator Group
0.7
0.5 – 0.8
Mindset Intervention Group
1.1
0.9 – 1.2
Survey-only Group
0.2
0.1 – 0.3
Osteoarthritis is Opportunistic
Group
Value
95% CI
Active Comparator Group
0.7
0.6 – 0.8
Mindset Intervention Group
1.1
1.0 – 1.2
Survey-only Group
0.2
0.0 – 0.3
Change From Baseline in Knee Pain and Functioning by the Short Version of Western Ontario and McMaster Universities Arthritis Index (shortMAC)Secondary· Change from Baseline at 1 month
The short-version of the Western Ontario and McMaster Universities Osteoarthritis Index (ShortMAC) is a disease-specific 12-item measure of knee pain, stiffness, and function. It has been validated and shown to be reliable in patients with knee osteoarthritis. It is measured on the Likert scale and can be divided into two subscales: pain and function. Pain subscore range, 0 (low pain) to 20 (high pain); Function subscore range, 0 (low difficulty) to 28 (high difficulty).
Pain
Group
Value
95% CI
Active Comparator Group
-0.6
-1.0 – -0.2
Mindset Intervention Group
-0.8
-1.2 – -0.4
Waitlist Control Group
-0.4
-0.7 – 0.0
Function
Group
Value
95% CI
Active Comparator Group
-0.7
-1.3 – -0.2
Mindset Intervention Group
-1.0
-1.5 – -0.4
Waitlist Control Group
-0.5
-1.1 – 0.0
Change From Baseline in Knee Osteoarthritis Knowledge by the Knee Osteoarthritis Knowledge ScaleSecondary· Change from Baseline at Post-intervention (immediately following intervention completion)
The Knee Osteoarthritis Knowledge Scale is scored from 11-55 and measures knowledge about osteoarthritis in individuals with knee or hip osteoarthritis.
Group
Value
95% CI
Mindset Intervention Group
10.5
9.4 – 11.6
Active Comparator (Education) Group
3.1
2.2 – 4.0
No-intervention (Survey-only) Control Group
0.6
-0.1 – 1.4
Change From Baseline in Perceived Need for Surgery by a Surgery Perception QuestionSecondary· Change from Baseline at 1 month
Perceived need for surgery will be assessed by the single question, "How likely do you think you are of needing knee replacement surgery in the future?" It is answered on the Likert scale from 1 (very unlikely) to 5 (very likely). All items are averaged together for a final score between 1 to 5.
Group
Value
95% CI
Mindset Intervention Group
-0.6
-0.7 – -0.4
Active Comparator (Education) Group
-0.2
-0.4 – 0.0
No-intervention (Survey-only) Control Group
0.0
-0.2 – 0.1
Change From Baseline in Symptom Management Strategy by an Osteoarthritis Symptom Management Question. The Variable is Reported as a % of Participants Who Reported Using the Symptom Management Strategy.Secondary· Change from Baseline at 1 month
Chosen symptom management strategy(ies) will be assessed by the single question, "Which of the following are ways in which you manage and/or improve your osteoarthritis symptoms? Please select all that apply." It is answer via multiple choice with multiple selection option. The options available are the most common strategies as determined by previous studies with an additional option for fill in. The reported value is the percentage of participants that selected the management strategy as a strategy they implement.
Pain medications
Group
Value
95% CI
Mindset Intervention Group
-3.8
-12.5 – 4.8
Active Comparator (Education) Group
4.4
-0.1 – 9.0
No-intervention (Survey-only) Control Group
-9.1
-16.1 – -2.1
Injections
Group
Value
95% CI
Mindset Intervention Group
-6.2
-13.8 – 1.5
Active Comparator (Education) Group
3.7
-4.1 – 11.5
No-intervention (Survey-only) Control Group
0.7
-5.9 – 7.3
Exercise
Group
Value
95% CI
Mindset Intervention Group
20.8
12.8 – 28.7
Active Comparator (Education) Group
16.3
7.2 – 25.3
No-intervention (Survey-only) Control Group
6.3
-1.5 – 14.1
Supervised physical therapy
Group
Value
95% CI
Mindset Intervention Group
-2.3
-9.2 – 4.6
Active Comparator (Education) Group
4.4
-2.7 – 11.5
No-intervention (Survey-only) Control Group
-2.8
-10.3 – 4.7
Rest
Group
Value
95% CI
Mindset Intervention Group
-1.5
-10.7 – 7.0
Active Comparator (Education) Group
11.1
3.2 – 19.0
No-intervention (Survey-only) Control Group
-1.4
-8.9 – 6.1
Imposing physical limitations
Group
Value
95% CI
Mindset Intervention Group
-19.2
-28.3 – -10.1
Active Comparator (Education) Group
5.2
-4.3 – 14.7
No-intervention (Survey-only) Control Group
-7.7
-16.8 – 1.4
Diet or weight management
Group
Value
95% CI
Mindset Intervention Group
17.7
8.2 – 27.0
Active Comparator (Education) Group
14.8
7.0 – 22.7
No-intervention (Survey-only) Control Group
11.2
3.1 – 19.2
Self-soothing
Group
Value
95% CI
Mindset Intervention Group
10.0
1.0 – 19.0
Active Comparator (Education) Group
0.7
-8.6 – 10.1
No-intervention (Survey-only) Control Group
-2.1
-10.0 – 5.8
Change From Baseline in Fear of Movement by the Brief Fear of Movement Scale for OsteoarthritisSecondary· Change from Baseline at 1 month
The Brief Fear of Movement Scale for Osteoarthritis is a 6-item scale validated to assess fear of movement in individuals with osteoarthritis. All items are averaged for a final score range of 1 (low fear) to 4 (high fear).
Group
Value
95% CI
Mindset Intervention Group
-0.4
-0.5 – -0.3
Active Comparator (Education) Group
-0.2
-0.7 – 0.5
No-intervention (Survey-only) Control Group
0.0
0.0 – 0.1
Change From Baseline in Arthritis Self-efficacy: Pain and Other Symptoms by the Arthritis Self-efficacy Pain and Other Symptoms SubscalesSecondary· Change from Baseline at 1 month
The Arthritis-Self Efficacy Scale is scored from a 1 to 10 with higher scores indicating greater self-efficacy. The scale will be divided into the "pain" and "other symptoms" subscales. The items on each subscale are averaged for a final score from 1 to 10.
Pain
Group
Value
95% CI
Mindset Intervention Group
1.4
1.1 – 1.7
Active Comparator (Education) Group
0.6
0.4 – 0.9
No-intervention (Survey-only) Control Group
0.1
0.0 – 0.5
Other symptoms
Group
Value
95% CI
Mindset Intervention Group
1.1
0.9 – 1.4
Active Comparator (Education) Group
0.6
0.3 – 0.9
No-intervention (Survey-only) Control Group
0.5
0.3 – 0.8
Change From Baseline in Physical and Mental Health: Global Health: Patient-Reported Outcomes Measurement Information System (PROMIS) Scale v1.2 - Global Health (Physical and Mental Health Sub-scales)Secondary· Change from Baseline at 1 month
The PROMIS v.1.1 Global Health Short Form is a 10-item survey that measures overall physical function, fatigue, pain, emotional distress, and social health in healthy and clinical adult populations. It will be divided into two subscales: physical health and mental health. The Physical Health subscore ranges from 1 (poor) to 5 (excellent). The Mental Health subscore ranges from 1 (poor) to 5 (excellent).
Physical health
Group
Value
95% CI
Mindset Intervention Group
0.2
0.1 – 0.2
Active Comparator (Education) Group
0.1
0.0 – 0.2
No-intervention (Survey-only) Control Group
0.0
0.0 – 0.1
Mental health
Group
Value
95% CI
Mindset Intervention Group
0.1
0.0 – 0.2
Active Comparator (Education) Group
0.0
-0.5 – 0.5
No-intervention (Survey-only) Control Group
0.0
-0.1 – 0.06
Change From Baseline in Body Mindset by the Illness Mindset InventorySecondary· Change from Baseline at Post-intervention (immediately following intervention completion)
The Illness Mindset Inventory measures three mindsets about the nature of the body in the context of a chronic illness: that it is adversarial, responsive, or resilient. The scale consists of 20 items measured on a 6-point scale and scored from 1 to 6, with 10 of those questions capturing mindsets about the body. The extent to which a participant endorses a particular mindset can be obtained by calculating the mean score for each mindset. A higher score indicates greater agreement with the mindset. The investigators adapted the scale to focus on mindsets about "knee osteoarthritis" as opposed
The Body is Adversarial
Group
Value
95% CI
Mindset Intervention Group
-0.6
-0.8 – -0.5
Active Comparator (Education) Group
-0.4
-0.5 – -0.2
No-intervention (Survey-only) Control Group
-0.1
-0.1 – 0.0
The Body is Capable
Group
Value
95% CI
Mindset Intervention Group
1.3
1.2 – 1.5
Active Comparator (Education) Group
0.6
0.4 – 0.7
No-intervention (Survey-only) Control Group
0.2
0.0 – 0.3
The Body is Responsive
Group
Value
95% CI
Mindset Intervention Group
0.7
0.5 – 0.8
Active Comparator (Education) Group
0.4
0.3 – 0.5
No-intervention (Survey-only) Control Group
0.2
0.0 – 0.2
Sponsor's own description
The aim of our clinical trial is to test if an online mindset intervention improves mindsets and physical activity levels more than an education intervention in individuals with knee osteoarthritis.
Publications & conference data
1 peer-reviewed publication reference this trial (live from Europe PMC):
Publications: Europe PMC API search by NCT ID, retrieved 10 June 2026
Drug + disease cross-links: matched in real time against Drug Landscape's normalised drug + company + condition tables
Sponsor: as reported to ClinicalTrials.gov by Stanford University
Last refreshed: 13 February 2025
Drug Landscape aggregates and links these public records for informational use only. Always verify against the primary source before clinical or regulatory decisions. Canonical URL: https://druglandscape.com/trial/NCT05698368.