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It works by inhibiting the reuptake of serotonin and norepinephrine.

It works by inhibiting the reuptake of serotonin and norepinephrine. Used for Major depressive disorder, Generalized anxiety disorder.

At a glance

Mechanism of action

This leads to an increase in the levels of these neurotransmitters in the brain, which helps to improve mood and reduce symptoms of depression. The exact mechanism is complex and not fully understood, but it is thought to involve the inhibition of the reuptake of serotonin and norepinephrine by the presynaptic neuron, allowing more of these neurotransmitters to be available for binding to postsynaptic receptors.

Approved indications

• Major depressive disorder
• Generalized anxiety disorder

Common side effects

• Nausea
• Headache
• Dizziness
• Insomnia
• Fatigue

Key clinical trials

• Assessment of Periprosthetic Bone Mineral Density in Patients Undergoing Total Knee Prosthesis of Different Design (NA)
• Safety and Efficacy of L. Lactis CKDB001 in Subjects With Early Alzheimer's Disease (NA)
• Phase I Trial of High-Density Theta Burst Stimulation (hdTBS) (PHASE1)
• Attitude and Success Rate of Women With Pelvic Organ Prolapse on Self-management of Vaginal Pessary (NA)
• A Study of Targeted Radiation Therapy in People With Non-Small Cell Lung Cancer (NSCLC) (PHASE2)
• Testing the Addition of a New Anti-Cancer Drug, Triapine, to the Usual Chemotherapy Treatment (Cisplatin) During Radiation Therapy for Advanced-stage Cervical and Vaginal Cancers (PHASE3)
• Short-term Steroid Therapy in Patients With P. Jirovecii Pneumonia Due to HIV / AIDS (NA)
• Safety and Efficacy Study of BRIMOCHOL™, BRIMOCHOL™ F, and Carbachol in Subjects With Emmetropic Phakic and Pseudophakic Presbyopia (PHASE2)

Primary sources

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