NCT05691699 is a Phase 1 clinical trial of ABBV-903 in Healthy Volunteer, sponsored by AbbVie.

Who is sponsoring NCT05691699?

NCT05691699 is sponsored by AbbVie.

What drugs are being tested in NCT05691699?

Interventions in NCT05691699: ABBV-903, Placebo for ABBV-903, Itraconazole.

What condition does NCT05691699 study?

NCT05691699 studies Healthy Volunteer.

Is NCT05691699 still recruiting?

NCT05691699 is currently completed. Last updated 30 October 2023.

Last reviewed 2023-10-30 · How we verify

NCT05691699

Name: Drug Landscape Pharmaceutical Database
Creator: Drug Landscape
Published: 2026-01-01
License: https://creativecommons.org/licenses/by/4.0/

A Study to Assess Adverse Events and How Single and Multiple Ascending Doses of ABBV-903 Move Through the Body in Healthy Adults

Completed Phase 1 Last updated 30 October 2023

What this trial tests

Phase 1 trial testing ABBV-903 in Healthy Volunteer in 104 participants. Completed in 23 October 2023.

Timeline

3 January 2023

Primary endpoint
23 October 2023

23 October 2023

Quick facts

Lead sponsor	AbbVie
Phase	Phase 1
Status	Completed
Study type	INTERVENTIONAL
Allocation	randomized
Design	sequential
Masking	quadruple
Primary purpose	treatment
Enrollment	104
Start date	3 January 2023
Primary completion	23 October 2023
Estimated completion	23 October 2023
Sites	1 location across United States

Drugs / interventions tested

ABBV-903 — full drug profile →
Placebo for ABBV-903 — full drug profile →
Itraconazole — full drug profile →

Conditions studied

Healthy Volunteer — all drugs for Healthy Volunteer →

Sponsor

AbbVie — full company profile →

Who can join

Adults 18 to 65, any sex, with Healthy Volunteer. Patients with the condition only — healthy volunteers not accepted.

Sponsor's own description

The purpose of this study is to evaluate adverse events and tolerability of single and multiple doses of ABBV-903, and to assess how the drug moves through the body in healthy adult volunteers.

Publications & conference data

3 peer-reviewed publications reference this trial (live from Europe PMC):

Pharmacokinetic Drug Interaction Studies of Limnetrelvir with Midazolam and Itraconazole in Healthy Participants.
Desai JM, Chowdhury EA, Ali I, Lee CM, et al · · 2026 · PMID 42133202 · DOI 10.1007/s40261-026-01551-1
Pharmacokinetic profiling of limnetrelvir in non-Japanese and Japanese populations: results of two phase 1 single- and multiple-dose studies.
Chowdhury EA, Lee CM, Desai JM, Ali I, et al · · 2026 · PMID 41870065 · DOI 10.1128/aac.01443-25
Research Progress on the Structure and Function, Immune Escape Mechanism, Antiviral Drug Development Methods, and Clinical Use of SARS-CoV-2 M<sup>pro</sup>.
Ren J, Zhang Z, Xia Y, Zhao D, et al · · 2025 · PMID 39860219 · DOI 10.3390/molecules30020351

Verify or expand the search:

Other trials of ABBV-903

Trials testing the same drug.

NCT06078202 — A Study to Assess the Relative Bioavailability of Three Immediate-Release Tablet Formulations of ABBV-903 in Healthy Adu · Phase 1 · withdrawn
NCT06009237 — A Study to Assess Pharmacokinetics, Safety, and Tolerability of ABBV-903 in Healthy Japanese and Han Chinese Participant · Phase 1 · terminated
NCT05995366 — A Study to Assess the Mass Balance of [14C] ABBV-903 in Healthy Male Participants Following Single Oral Dose Administrat · Phase 1 · completed
NCT05895266 — A Study to Assess Drug-Drug Interaction Between ABBV-903 and Midazolam in Adult Healthy Volunteers · Phase 1 · completed

Other recruiting trials for Healthy Volunteer

Currently open trials in the same condition.

NCT06274749 — Effects of Urolithin A Supplementation on Glucose Metabolism in Healthy Adults 55 >= Years Old: A Randomized Triple-Mask · NA · recruiting
NCT05652478 — Early Metabolic Effects of Antiretroviral Drugs in Healthy volUnteers: a Phase 2 Randomized Study · Phase 2 · recruiting
NCT06845176 — Combining Motor Imagery and Tendon Vibration on the Effectiveness of Motor Imagery · NA · recruiting
NCT07439263 — Single Ascending Dose Study of HB2198 in Healthy Participants · Phase 1 · recruiting
NCT07220122 — Impact of Exogenous Ketones on Breathing in Healthy Volunteers · EARLY_PHASE1 · recruiting

Other AbbVie trials

Trials by the same sponsor.

NCT07219017 — A Study to Assess the Mass Balance of Oral ABBV-1354 in Healthy Adult Male Participants · Phase 1 · completed
NCT05316220 — A Study to Assess Adverse Events and Change in Disease Condition of Mesalamine Capsules in Children Aged 5 to 17 Years W · Phase 3 · withdrawn
NCT07024797 — Study to Assess the Adverse Events, Tolerability, and How Oral Doses of ABBV-932 Moves Through the Body in Healthy Adult · Phase 1 · completed
NCT07058051 — Cross-sectional Study to Characterize Real World Burden of Disease in Patients With Vitiligo in China · completed
NCT07007091 — A Study to Assess the Relative Bioavailability of Risankizumab Following Subcutaneous Administrations With a Pre-Filled · Phase 1 · completed

Verify against primary sources

ClinicalTrials.gov — authoritative US registry record
WHO ICTRP — international registry index
EU Clinical Trials Register
Sponsor press releases (Google)

Data sources for this page

Trial protocol + status: ClinicalTrials.gov NCT05691699 (US National Library of Medicine, public domain)
Publications: Europe PMC API search by NCT ID, retrieved 9 June 2026
Drug + disease cross-links: matched in real time against Drug Landscape's normalised drug + company + condition tables
Sponsor: as reported to ClinicalTrials.gov by AbbVie
Last refreshed: 30 October 2023

Drug Landscape aggregates and links these public records for informational use only. Always verify against the primary source before clinical or regulatory decisions. Canonical URL: https://druglandscape.com/trial/NCT05691699.

Primary sources · FDA · ClinicalTrials.gov · EMA · SEC EDGAR · ChEMBL · Wikidata · full sourcing