NCT05682677 is a NA clinical trial of iTBS in Depression, sponsored by University of California, San Diego.

Who is sponsoring NCT05682677?

NCT05682677 is sponsored by University of California, San Diego.

What drugs are being tested in NCT05682677?

Interventions in NCT05682677: iTBS, sham iTBS, Personalized, Augmented Cognitive Training (PACT).

What condition does NCT05682677 study?

NCT05682677 studies Depression, Mild Traumatic Brain Injury, Concussion, Brain.

Is NCT05682677 still recruiting?

NCT05682677 is currently recruiting now. Last updated 5 November 2024.

Last reviewed 2024-11-05 · How we verify

NCT05682677

Name: Drug Landscape Pharmaceutical Database
Creator: Drug Landscape
Published: 2026-01-01
License: https://creativecommons.org/licenses/by/4.0/

Combined Neuromodulation and Cognitive Training for Post-mTBI Depression

Recruiting now NA Last updated 5 November 2024

What this trial tests

NA trial testing iTBS in Depression in 72 participants. Currently enrolling.

Timeline

19 September 2023

Primary endpoint
30 June 2026

30 June 2026

Quick facts

Lead sponsor	University of California, San Diego
Phase	NA
Status	Recruiting now
Study type	INTERVENTIONAL
Allocation	randomized
Design	parallel
Masking	quadruple
Primary purpose	treatment
Enrollment	72
Start date	19 September 2023
Primary completion	30 June 2026
Estimated completion	30 June 2026
Sites	1 location across United States

Drugs / interventions tested

iTBS
sham iTBS
Personalized, Augmented Cognitive Training (PACT)

Conditions studied

Depression — all drugs for Depression →
Mild Traumatic Brain Injury — all drugs for Mild Traumatic Brain Injury →
Concussion, Brain — all drugs for Concussion, Brain →

Sponsor

University of California, San Diego

Who can join

Adults 18 to 65, any sex, with Depression or Mild Traumatic Brain Injury. Patients with the condition only — healthy volunteers not accepted.

Sponsor's own description

The primary goal of this clinical trial is to evaluate whether Personalized Augmented Cognitive Training (PACT) plus intermittent theta burst stimulation (iTBS) is effective for treating depression in Service Members, Veterans, and civilians who have sustained a mild TBI. Participants will receive PACT plus 20 sessions of iTBS or sham iTBS over 4 weeks. Assessments will occur at baseline, 2 weeks, 4 weeks, and 8 weeks. Researchers will compare the PACT+iTBS group to the PACT+sham iTBS group to see if PACT+iTBS is associated with more depression improvement.

Publications & conference data

1 peer-reviewed publication reference this trial (live from Europe PMC):

Repetitive transcranial magnetic stimulation for post-traumatic stress disorder in adults.
Brown R, Cherian K, Jones K, Wickham R, et al · · 2024 · cited 6× · PMID 39092744 · DOI 10.1002/14651858.cd015040.pub2

Verify or expand the search:

Other trials of iTBS

Trials testing the same drug.

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Other recruiting trials for Depression

Currently open trials in the same condition.

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NCT06408246 — ACE-D Aim 3 Clinical Cognitive Trial to Enhance Translation in Depression · Phase 2 · recruiting
NCT07449676 — Effects of an Innovative TCM-based Tui Jing Therapy on Psychological and Neurophysiological Functions in Depression · NA · recruiting

Other University of California, San Diego trials

Trials by the same sponsor.

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NCT06505317 — Artificial Intelligence for Early Detection of Peripheral Artery Disease · NA · not yet recruiting
NCT07211802 — CKM For Safe Use of SGLT2i in Type 1 Diabetes · Phase 3 · not yet recruiting
NCT07524751 — Culturally Adapted Pain Management for Indigenous Peoples · NA · not yet recruiting
NCT07518784 — Accurate Point of Care Liver Disease Diagnostics (Phase 2) · recruiting

Verify against primary sources

ClinicalTrials.gov — authoritative US registry record
WHO ICTRP — international registry index
EU Clinical Trials Register
Sponsor press releases (Google)

Data sources for this page

Trial protocol + status: ClinicalTrials.gov NCT05682677 (US National Library of Medicine, public domain)
Publications: Europe PMC API search by NCT ID, retrieved 10 June 2026
Drug + disease cross-links: matched in real time against Drug Landscape's normalised drug + company + condition tables
Sponsor: as reported to ClinicalTrials.gov by University of California, San Diego
Last refreshed: 5 November 2024

Drug Landscape aggregates and links these public records for informational use only. Always verify against the primary source before clinical or regulatory decisions. Canonical URL: https://druglandscape.com/trial/NCT05682677.

Primary sources · FDA · ClinicalTrials.gov · EMA · SEC EDGAR · ChEMBL · Wikidata · full sourcing