Who is sponsoring KME-TBS?

KME-TBS is sponsored by Universiti Putra Malaysia.

What condition does KME-TBS study?

KME-TBS studies Healthy Young Adult, Neurophysiology.

What drugs are being tested in KME-TBS?

Interventions: Ketone Monoester (KME), Placebo, iTBS, cTBS.

What is the status of KME-TBS?

KME-TBS is currently ACTIVE_NOT_RECRUITING.

Last reviewed 2025-06-25 · How we verify

Motor Cortex Plasticity Response to Theta-Burst Stimulation After Ketone Monoester Supplementation (KME-TBS)

NCT06799260 NA ACTIVE_NOT_RECRUITING

Transcranial magnetic stimulation is a medical device that can alter motor cortical (M1) excitability through the scalp via various protocols. Among these, intermittent- and continuous-theta burst stimulation (iTBS/cTBS) are increasingly used protocols to enhance or suppress M1 excitability, respectively, beyond stimulation. However, the poor reproducibility and high inter-individual variability in responses to TBS protocols are matters of concern. This study will explore whether ketone monoester supplementation can boost TBS efficacy via their mechanistic convergence on Brain-Derived Neurotrophic Factor (BDNF).

Details

Lead sponsor	Universiti Putra Malaysia
Phase	NA
Status	ACTIVE_NOT_RECRUITING
Enrolment	40
Start date	Wed Dec 18 2024 00:00:00 GMT+0000 (Coordinated Universal Time)
Completion	Mon Dec 01 2025 00:00:00 GMT+0000 (Coordinated Universal Time)

Conditions

Healthy Young Adult
Neurophysiology

Interventions

Ketone Monoester (KME)
Placebo
iTBS
cTBS

Countries

Malaysia