Last reviewed · How we verify
NCT05676944
Vestibular Implantation in Older Adults
NA trial testing Labyrinth Devices MVI™ Multichannel Vestibular Implant System in Other Disorders of Vestibular Function, Bilateral in 15 participants. Currently enrolling.
30 September 2027
Quick facts
| Lead sponsor | Johns Hopkins University |
|---|---|
| Phase | NA |
| Status | Recruiting now |
| Study type | INTERVENTIONAL |
| Allocation | na |
| Design | single group |
| Masking | none |
| Primary purpose | treatment |
| Enrollment | 15 |
| Start date | 11 April 2023 |
| Primary completion | 30 September 2027 |
| Estimated completion | 31 January 2028 |
| Sites | 1 location across United States |
Drugs / interventions tested
- Labyrinth Devices MVI™ Multichannel Vestibular Implant System
Conditions studied
- Other Disorders of Vestibular Function, Bilateral — all drugs for Other Disorders of Vestibular Function, Bilateral →
- Bilateral Vestibular Deficiency (BVD) — all drugs for Bilateral Vestibular Deficiency (BVD) →
- Gentamicin Ototoxicity — all drugs for Gentamicin Ototoxicity →
- Labyrinth Diseases — all drugs for Labyrinth Diseases →
Sponsor
Johns Hopkins University
Who can join
Adults 65 to 90, any sex, with Other Disorders of Vestibular Function, Bilateral or Bilateral Vestibular Deficiency (BVD). Patients with the condition only — healthy volunteers not accepted.
Sponsor's own description
Although cochlear implants can restore hearing to individuals who have lost cochlear hair cell function, there is no widely available, adequately effective treatment for individuals suffering chronic imbalance, postural instability and unsteady vision due to bilateral vestibular hypofunction. Prior research has demonstrated that electrical stimulation of the vestibular nerve via a chronically implanted multichannel vestibular implant can partially restore vestibular reflexes that normally maintain steady posture and vision; improve performance on objective measures of postural stability and gait; and improve patient-reported disability and health-related quality of life. This single-arm open-label study extends that research to evaluate outcomes for up to fifteen older adults (age 65-90 years at time of enrollment) with ototoxic or non-ototoxic bilateral vestibular hypofunction.
Publications & conference data
1 peer-reviewed publication reference this trial (live from Europe PMC):
-
Vestibular Implant Surgery.
Schoo DP, Ward BK, Chow MR, Ayiotis AI, et al · · 2024 · cited 2× · PMID 37767871 · DOI 10.1002/lary.31004
Verify or expand the search:
- PubMed search for NCT05676944
- Europe PMC full search
- ASCO Meeting Library
- ESMO Meeting Library
- bioRxiv preprints
- medRxiv preprints
- Google Scholar
Related trials
Other trials of Labyrinth Devices MVI™ Multichannel Vestibular Implant System
Trials testing the same drug.
- NCT05674786 — Vestibular Implantation to Treat Adult-Onset Bilateral Vestibular Hypofunction · NA · recruiting
Other recruiting trials for Other Disorders of Vestibular Function, Bilateral
Currently open trials in the same condition.
- NCT05674786 — Vestibular Implantation to Treat Adult-Onset Bilateral Vestibular Hypofunction · NA · recruiting
Other Johns Hopkins University trials
Trials by the same sponsor.
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Verify against primary sources
- ClinicalTrials.gov — authoritative US registry record
- WHO ICTRP — international registry index
- EU Clinical Trials Register
- Sponsor press releases (Google)
- Trial protocol + status: ClinicalTrials.gov NCT05676944 (US National Library of Medicine, public domain)
- Publications: Europe PMC API search by NCT ID, retrieved 10 June 2026
- Drug + disease cross-links: matched in real time against Drug Landscape's normalised drug + company + condition tables
- Sponsor: as reported to ClinicalTrials.gov by Johns Hopkins University
- Last refreshed: 12 January 2026
Drug Landscape aggregates and links these public records for informational use only. Always verify against the primary source before clinical or regulatory decisions. Canonical URL: https://druglandscape.com/trial/NCT05676944.
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