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NCT05675865: FULCRUM-VT
Cryoablation for Monomorphic Ventricular Tachycardia
NA trial testing cryoablation procedure in Sustained VT in 206 participants. Currently enrolling.
31 January 2027
Quick facts
| Lead sponsor | Adagio Medical |
|---|---|
| Phase | NA |
| Status | Recruiting now |
| Study type | INTERVENTIONAL |
| Allocation | na |
| Design | single group |
| Masking | none |
| Primary purpose | treatment |
| Enrollment | 206 |
| Start date | 11 September 2023 |
| Primary completion | 31 January 2027 |
| Estimated completion | 30 March 2027 |
| Sites | 15 locations across Canada, United States |
Drugs / interventions tested
- cryoablation procedure
Conditions studied
- Sustained VT — all drugs for Sustained VT →
Sponsor
Adagio Medical — full company profile →
Who can join
18 and older, any sex, with Sustained VT. Patients with the condition only — healthy volunteers not accepted.
Sponsor's own description
The objective of this clinical study is to evaluate the safety and effectiveness of the Adagio VT Cryoablation System in the ablation treatment of Sustained Monomorphic Ventricular Tachycardia (SMVT)
Publications & conference data
4 peer-reviewed publications reference this trial (live from Europe PMC):
-
Targeting Ventricular Arrhythmias in Non-Ischemic Patients: Advances in Diagnosis and Treatment.
Stanciulescu LA, Dorobantu M, Vatasescu R. · · 2025 · cited 2× · PMID 40002571 · DOI 10.3390/diagnostics15040420 -
“From Surface to Substrate: Advancing VT Ablation Strategies for Deep Arrhythmic Substrates”—A Review of Emerging Techniques in Intramural Lesion Formation
Akrawinthawong K, Jakulla R, Yamada T. · · 2026 -
Ablation Methods and Catheter Settings for Ventricular Tachycardia Ablation: A Bench to Bedside Review: Part 2.
Niespialowska-Steuden M, Silberbauer J, Al-Sheikhli J, Siang R, et al · · 2026 · PMID 42170357 · DOI 10.15420/aer.2025.74 -
Ultra-Low Cryoablation for Scar-Related VT Ablation: Results From the US Early Feasibility Study.
Weiss JP, Reddy VY, Tandri H, Richardson TD, et al · · 2026 · PMID 41623095 · DOI 10.1161/circep.125.014095
Verify or expand the search:
- PubMed search for NCT05675865
- Europe PMC full search
- ASCO Meeting Library
- ESMO Meeting Library
- bioRxiv preprints
- medRxiv preprints
- Google Scholar
Related trials
Other recruiting trials for Sustained VT
Currently open trials in the same condition.
- NCT06891456 — Pulsed Field Ablation for Post-Infarction Ventricular Tachycardia · NA · recruiting
Other Adagio Medical trials
Trials by the same sponsor.
- NCT06384599 — VT Cryoablation System Post-Market Clinical Follow-up (PMCF) Study · NA · not yet recruiting
- NCT05408754 — Pulsed Field Ablation and Pulsed Field CRyoAbLation in PErsistent AtriaL FibrilLation · NA · completed
- NCT05416086 — iCLAS™ Cryoablation System Post-Market Clinical Follow-up (PMCF) Study · NA · terminated
- NCT04893317 — Cryoablation for Monomorphic Ventricular Tachycardia (CryoCure-VT) · NA · completed
- NCT04061603 — iCLAS™ for Persistent Atrial Fibrillation · NA · completed
Verify against primary sources
- ClinicalTrials.gov — authoritative US registry record
- WHO ICTRP — international registry index
- EU Clinical Trials Register
- Sponsor press releases (Google)
- Trial protocol + status: ClinicalTrials.gov NCT05675865 (US National Library of Medicine, public domain)
- Publications: Europe PMC API search by NCT ID, retrieved 10 June 2026
- Drug + disease cross-links: matched in real time against Drug Landscape's normalised drug + company + condition tables
- Sponsor: as reported to ClinicalTrials.gov by Adagio Medical
- Last refreshed: 7 April 2026
Drug Landscape aggregates and links these public records for informational use only. Always verify against the primary source before clinical or regulatory decisions. Canonical URL: https://druglandscape.com/trial/NCT05675865.
Primary sources · FDA · ClinicalTrials.gov · EMA · SEC EDGAR · ChEMBL · Wikidata · full sourcing