NCT04893317: CryoCure-VT

Cryoablation for Monomorphic Ventricular Tachycardia (CryoCure-VT)

Completed NA Last updated 19 March 2026

What this trial tests

NA trial testing Ablation in the ventricles with the Adagio Medical VT Cryoablation System in Monomorphic Ventricular Tachycardia in 64 participants. Completed in 30 September 2024.

Timeline

26 May 2021

Primary endpoint
30 June 2024

30 September 2024

Quick facts

Lead sponsor	Adagio Medical
Phase	NA
Status	Completed
Study type	INTERVENTIONAL
Allocation	na
Design	single group
Masking	none
Primary purpose	treatment
Enrollment	64
Start date	26 May 2021
Primary completion	30 June 2024
Estimated completion	30 September 2024
Sites	7 locations across France, Netherlands, Belgium, Germany, Canada, Czechia

Drugs / interventions tested

• Ablation in the ventricles with the Adagio Medical VT Cryoablation System

Conditions studied

• Monomorphic Ventricular Tachycardia — all drugs for Monomorphic Ventricular Tachycardia →

Sponsor

Adagio Medical — full company profile →

Who can join

18 and older, any sex, with Monomorphic Ventricular Tachycardia. Patients with the condition only — healthy volunteers not accepted.

Sponsor's own description

A prospective, single-arm, multi-center, pre-market, clinical study designed to provide safety and performance data regarding the use of the Adagio Medical VT Cryoablation System in the treatment of ventricular tachycardia.

Publications & conference data

5 peer-reviewed publications reference this trial (live from Europe PMC):

1. First-in-Human Experience With Ultra-Low Temperature Cryoablation for Monomorphic Ventricular Tachycardia.
   De Potter T, Balt JC, Boersma L, Sacher F, et al · · 2023 · cited 14× · PMID 36752466 · DOI 10.1016/j.jacep.2022.11.017
2. Cryocure-VT: the safety and effectiveness of ultra-low-temperature cryoablation of monomorphic ventricular tachycardia in patients with ischaemic and non-ischaemic cardiomyopathies.
   Verma A, Essebag V, Neuzil P, Dyrda K, et al · · 2024 · cited 13× · PMID 38582974 · DOI 10.1093/europace/euae076
3. Solving the Reach Problem: A Review of Present and Future Approaches for Addressing Ventricular Arrhythmias Arising from Deep Substrate.
   Ravi V, Winterfield J, Liang J, Larsen T, et al · · 2023 · cited 3× · PMID 37600155 · DOI 10.15420/aer.2022.28
4. Ultra-Low-Temperature Cryoablation for Ventricular Tachycardia: An Early Single-Centre Report of Acute Results.
   Sanchez-Somonte P, Verma A, Da Rosa LB, Anglesio V, et al · · 2024 · cited 2× · PMID 38559338 · DOI 10.1016/j.cjco.2023.11.009
5. Ultra-low-temperature cryoablation for ventricular tachycardia in nonischemic cardiomyopathy-A case report.
   Dilk P, Darma A, Hindricks G, Dinov B. · · 2023 · cited 1× · PMID 37492043 · DOI 10.1016/j.hrcr.2023.04.012